Second-Coordination-Sphere
Effects Increase the Catalytic Efficiency of an Extended Model for
Fe<sup>III</sup>M<sup>II</sup> Purple Acid Phosphatases
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Abstract
Herein we describe the synthesis
of a new heterodinuclear Fe<sup>III</sup>Cu<sup>II</sup> model complex
for the active site of purple acid phosphatases and its binding to
a polyamine chain, a model for the amino acid residues around the
active site. The properties of these systems and their catalytic activity
in the hydrolysis of bis(2,4-dinitrophenyl)phosphate are compared,
and conclusions regarding the effects of the second coordination sphere
are drawn. The positive effect of the polymeric chain on DNA hydrolysis
is also described and discussed
