Prehistoric psychotropic consumption in Andean Chilean mummies

Hallucinogenic plants are often regarded as the main source of psychoactive drugs in antiquity to reach deep altered states of consciousness^1,2^. Many researchers believe this was particularly true during the Tiwanaku empire expansion, circa (500-1000 A.D.), along the Atacama Desert of Chile. Highly decorated snuffing tablets and tubes are often found as grave goods during this period^3,4,5,6,7,8^. Until now the type of drugs consumed in this paraphernalia has been unclear. From the modern city of Arica, naturally mummified human bodies with abundant hair provided a unique opportunity to test for hallucinogenic plants consumed in Andean prehistory. Analysis by gas chromatography and mass spectrometry demonstrated the presence of harmine. The Banisteriopsis vine, commonly called Ayahuasca, was the probable source. This is the first confirmed evidence of psychoactive plant consumption in pre-Hispanic Andean populations along the Atacama coastal region. Of the 32 mummy hair samples analyzed 3 males tested positive for harmine. This alkaloid aids in the catalysis and synergic effects of powerful hallucinogenic drugs. The consumption of harmine was likely related to medicinal practices and not exclusively ingested by shamans. Another important aspect of this evidence is that Banisteriopsis is an Amazon plant. It does not grow in the Atacama coastal region. Thus, our findings reveal extensive plant trade networks in antiquity between the coast, desert, highlands, and Amazon basin. The excellent preservation of human organic specimens, the use of gas chromatography and mass spectrometry allowed us to map and demonstrate the consumption of psychoactive compound plants in Andean prehistory. In addition, our findings open the door for future studies to debate the consumption and social role of ancient psychoactive and hallucinogenic plants

An efficiency analysis of banking systems: a comparison of European and United States large commercial banks using different functional forms.

This paper aims at investigation the efficiency of European and U.S. commercial banks. Scale and scope economies indicators, as well as a measurement of X-efficiency are derived from three cost functions: Fourier flexible form, translog and Box-Cox. This allows checking the stability and the robustness of the evidence across the different specifications. Our results over the period 1995-98 show that overall the average cost curve is relatively flat with some evidence of scale efficiency gains. More puzzling are the results on the presence of scope economies.

Complex delay dynamics on railway networks: from universal laws to realistic modelling

Railways are a key infrastructure for any modern country. The reliability and resilience of this peculiar transportation system may be challenged by different shocks such as disruptions, strikes and adverse weather conditions. These events compromise the correct functioning of the system and trigger the spreading of delays into the railway network on a daily basis. Despite their importance, a general theoretical understanding of the underlying causes of these disruptions is still lacking. In this work, we analyse the Italian and German railway networks by leveraging on the train schedules and actual delay data retrieved during the year 2015. We use {these} data to infer simple statistical laws ruling the emergence of localized delays in different areas of the network and we model the spreading of these delays throughout the network by exploiting a framework inspired by epidemic spreading models. Our model offers a fast and easy tool for the preliminary assessment of the {effectiveness of} traffic handling policies, and of the railway {network} criticalities.Comment: 32 pages (with appendix), 28 Figures (with appendix), 2 Table

A DYNAMIC ANALYSIS OF THE IMPACT OF WATER QUALITY POLICIES ON IRRIGATION INVESTMENT AND CROP CHOICE DECISIONS

A dynamic model is developed to analyze farmers' irrigation investment and crop choice decisions under alternative water quality protection policies. The model is applied to an empirical example in the Oklahoma High Plains. The choices of crops and irrigation systems and the resulting levels of irrigation, income, and nitrogen runoff and percolation are simulated over a ten-year period. An effluent tax on nitrogen runoff and percolation is shown to be effective in reducing nitrate pollution. The efficacy of cost sharing in adopting modern irrigation technologies and restrictions on irrigation water use depends on soil type. A tax on nitrogen use is shown to be the least effective policy.Crop selection, Dynamic optimization, Irrigation investment, Water quality, Crop Production/Industries,

Ensuring Trust in One Time Exchanges: Solving the QoS Problem

We describe a pricing structure for the provision of IT services that ensures trust without requiring repeated interactions between service providers and users. It does so by offering a pricing structure that elicits truthful reporting of quality of service (QoS) by providers while making them profitable. This mechanism also induces truth-telling on the part of users reserving the service

Fish-based groups for ecological assessment in rivers: the importance of environmental drivers on taxonomic and functional traits of fish Assemblages

The use of river-types is of practical value, serving as groups for which assessment procedures can be developed and applied. An abiotic typology was set by the Portuguese Water Agency, mainly based on 6 major morphoclimatic regions. However, to be biologically meaningful, this typology should fit the distribution patterns of the biological quality elements communities proposed in Water Framework Directive under the lowest possible human pressure. This study aimed to identify and characterize fish-based geographical groups for continental Portugal and their environmental and geographical discriptors, using taxonomic and functional traits. Sampling took place between 2004 and 2006 during Spring. Fish fauna from 155 reference sites was analysed using a multivariate approach. Cluster Analysis on fish composition identified 10 fish-groups, expressing a clear correspondence to the river basin level, due to the restrict basin distribution of many species. Groups showed a wider aggregation in 4 regions with a larger geographical correspondence, statistically supported by Similarity Analysis, both on fish composition and mostly on fish metrics/guilds. Principal Components Analysis revealed major environmental drivers associated to fish-groups and fish-regions. Fish-groups were hierarchically grouped over major and local regions, expressing a large-scale response to a North-South environmental gradient defined by temperature, precipitation, mineralization and altitude, and a regional scale response mainly to drainage area and flow discharge. From North to South, fish-regions were related to the morphoclimatic regions. Results contributed to reduce redundance in abiotic river-types and set the final typology for Portuguese rivers, constituting a fundamental tool for planning and managing water resources

Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei

The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis. Trypanosomatid cytoskeletons contain abundant high molecular mass proteins (HMMPs), but many of their biological functions are still unclear. Here, we report the characterization of the giant FAZ protein, FAZ10, in Trypanosoma brucei, which, using immunoelectron microscopy, we show localizes to the intermembrane staples in the FAZ intracellular domain. Our data show that FAZ10 is a giant cytoskeletal protein essential for normal growth and morphology in both procyclic and bloodstream parasite life cycle stages, with its depletion leading to defects in cell morphogenesis, flagellum attachment, and kinetoplast and nucleus positioning. We show that the flagellum attachment defects are probably brought about by reduced tethering of the proximal domain of the paraflagellar rod to the FAZ filament. Further, FAZ10 depletion also reduces abundance of FAZ flagellum domain protein, ClpGM6. Moreover, ablation of FAZ10 impaired the timing and placement of the cleavage furrow during cytokinesis, resulting in premature or asymmetrical cell division