Theoretical investigation of FeTe magnetic ordering under hydrostatic pressure

We investigate the pressure phase diagram of FeTe, predicting structural and magnetic properties in the normal state at zero temperature within density functional theory (DFT). We carefully examined several possible different crystal structures over a pressure range up to $\approx 30$ GPa: simple tetragonal (PbO type), simple monoclinic, orthorhombic (MnP type), hexagonal (NiAs and wurzite type) and cubic (CsCl and NaCl type). We predict pressure to drive the system through different magnetic ordering (notably also some ferromagnetic phases) eventually suppressing magnetism at around 17GPa. We speculate the ferromagnetic order to be the reason for the absence of a superconducting phase in FeTe at variance with the case of FeSe.Comment: 11 figure

The Amati relation in the "fireshell" model

(Shortened) CONTEXT: [...] AIMS: Motivated by the relation proposed by Amati and collaborators, we look within the ``fireshell'' model for a relation between the peak energy E_p of the \nu F_\nu total time-integrated spectrum of the afterglow and the total energy of the afterglow E_{aft}, which in our model encompasses and extends the prompt emission. METODS: [...] Within the fireshell model [...] We can then build two sets of ``gedanken'' GRBs varying the total energy of the electron-positron plasma E^{e^\pm}_{tot} and keeping the same baryon loading B of GRB050315. The first set assumes for the effective CBM density the one obtained in the fit of GRB050315. The second set assumes instead a constant CBM density equal to the average value of the GRB050315 prompt phase. RESULTS: For the first set of ``gedanken'' GRBs we find a relation E_p\propto (E_{aft})^a, with a = 0.45 \pm 0.01, whose slope strictly agrees with the Amati one. Such a relation, in the limit B \to 10^{-2}, coincides with the Amati one. Instead, in the second set of ``gedanken'' GRBs no correlation is found. CONCLUSIONS: Our analysis excludes the Proper-GRB (P-GRB) from the prompt emission, extends all the way to the latest afterglow phases and is independent on the assumed cosmological model, since all ``gedanken'' GRBs are at the same redshift. The Amati relation, on the other hand, includes also the P-GRB, focuses on the prompt emission only, and is therefore influenced by the instrumental threshold which fixes the end of the prompt emission, and depends on the assumed cosmology. This may well explain the intrinsic scatter observed in the Amati relation.Comment: 4 pages, 5 figures, to appear on A&A Letter

The X-ray light curve of Gamma-ray bursts: clues to the central engine

We present the analysis of a large sample of gamma-ray burst (GRB) X-ray light curves in the rest frame to characterise their intrinsic properties in the context of different theoretical scenarios. We determine the morphology, time scales, and energetics of 64 long GRBs observed by \emph{Swift}/XRT \emph{without} flaring activity. We furthermore provide a one-to-one comparison to the properties of GRBs \emph{with} X-ray flares. We find that the steep decay morphology and its connection with X-ray flares favour a scenario in which a central engine origin. We show that this scenario can also account for the shallow decay phase, provided that the GRB progenitor star has a self-similar structure with a constant envelope-to-core mass ratio $\sim 0.02-0.03$. However, difficulties arise for very long duration ($t_p\gtrsim10^4$ s) shallow phases. Alternatively, a spinning-down magnetar whose emitted power refreshes the forward shock can quantitatively account for the shallow decay properties. In particular we demonstrate that this model can account for the plateau luminosity vs. end time anticorrelation.Comment: 12 pages, 8 figures, accepted for publication in A&

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner.

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines. Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment. Conversely, U251 cell line showed a resistant phenotype in response to axitinib treatment, as evidenced by cell cycle arrest but no sign of cell death. The combinatorial use of axitinib with other therapies, with the aim of inhibiting multiple signaling pathways involved in tumor growth, can increase the efficiency of this TKI. Thus, we addressed the combined effects of axitinib with no toxic doses of the proteasome inhibitor bortezomib on the growth of U87 and T98 axitinib- sensitive and axitinib-resistant U251 cell lines. Compared to single treatments, combined exposure was more effective in inhibiting cell viability of all glioma cell lines, although with different cell death modalities. The regulation of key DDR and cell cycle proteins, including Chk1, γ-H2AX and p21(Waf1/Cip1) was also studied in glioma cell lines. Collectively, these findings provide new perspectives for the use of axitinib in combination with Bortezomib to overcome the therapy resistance in gliomas

Accurate calculation of polarization-related quantities in semiconductors

We demonstrate that polarization-related quantities in semiconductors can be predicted accurately from first-principles calculations using the appropriate approach to the problem, the Berry-phase polarization theory. For III-V nitrides, our test case, we find polarizations, polarization differences between nitride pairs, and piezoelectric constants quite close to their previously established values. Refined data are nevertheless provided for all the relevant quantities.Comment: RevTeX 4 pages, no figure

Effect of ELF e.m. fields on metalloprotein redox-active sites

The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and removal of free radicals. We observed that Superoxide radicals generation by XO is increased by a weak field having the Larmor frequency fL of Fe2+ while the SOD1 kinetics is sensibly reduced by exposure to a weak field having the frequency fL of Cu2+ ion.Comment: 18 pages, 4 figure

GRB970228 and the class of GRBs with an initial spikelike emission: do they follow the Amati relation?

On the basis of the recent understanding of GRB050315 and GRB060218, we return to GRB970228, the first Gamma-Ray Burst (GRB) with detected afterglow. We proposed it as the prototype for a new class of GRBs with "an occasional softer extended emission lasting tenths of seconds after an initial spikelike emission". Detailed theoretical computation of the GRB970228 light curves in selected energy bands for the prompt emission are presented and compared with observational BeppoSAX data. From our analysis we conclude that GRB970228 and likely the ones of the above mentioned new class of GRBs are "canonical GRBs" have only one peculiarity: they exploded in a galactic environment, possibly the halo, with a very low value of CBM density. Here we investigate how GRB970228 unveils another peculiarity of this class of GRBs: they do not fulfill the "Amati relation". We provide a theoretical explanation within the fireshell model for the apparent absence of such correlation for the GRBs belonging to this new class.Comment: 5 pages, 3 figures, in the Proceedings of the "4th Italian-Sino Workshop on Relativistic Astrophysics", held in Pescara, Italy, July 20-28, 2007, C.L. Bianco, S.-S. Xue, Editor

First-principles prediction of structure, energetics, formation enthalpy, elastic constants, polarization, and piezoelectric constants of AlN, GaN, and InN: comparison of local and gradient-corrected density-functional theory

A number of diverse bulk properties of the zincblende and wurtzite III-V nitrides AlN, GaN, and InN, are predicted from first principles within density functional theory using the plane-wave ultrasoft pseudopotential method, within both the LDA (local density) and GGA (generalized gradient) approximations to the exchange-correlation functional. Besides structure and cohesion, we study formation enthalpies (a key ingredient in predicting defect solubilities and surface stability), spontaneous polarizations and piezoelectric constants (central parameters for nanostructure modeling), and elastic constants. Our study bears out the relative merits of the two density functional approaches in describing diverse properties of the III-V nitrides (and of the parent species N$_2$, Al, Ga, and In), and leads us to conclude that the GGA approximation, associated with high-accuracy techniques such as multiprojector ultrasoft pseudopotentials or modern all-electron methods, is to be preferred in the study of III-V nitrides.Comment: RevTeX 6 pages, 12 tables, 0 figure

There is a short gamma-ray burst prompt phase at the beginning of each long one

We compare the prompt intrinsic spectral properties of a sample of short Gamma--ray Burst (GRB) with the first 0.3 seconds (rest frame) of long GRBs observed by Fermi/GBM. We find that short GRBs and the first part of long GRBs lie on the same E_p--E_iso correlation, that is parallel to the relation for the time averaged spectra of long GRBs. Moreover, they are indistinguishable in the E_p--L_iso plane. This suggests that the emission mechanism is the same for short and for the beginning of long events, and both short and long GRBs are very similar phenomena, occurring on different timescales. If the central engine of a long GRB would stop after ~0.3 * (1+z) seconds the resulting event would be spectrally indistinguishable from a short GRB.Comment: 14 pages, 6 figures, MNRAS accepte