88 research outputs found
Prognostic importance of lymphovascular invasion in urothelial carcinoma of the renal pelvis
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144274/1/cncr31372_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144274/2/cncr31372.pd
Generation tourism: towards a common identity
The purpose of this article is to highlight the implications of the indiscipline of tourism academia for a new generation of tourism academics. Generation Tourism is characterised by scholars with a multi-disciplinary education associated with a broad field of study and commonly considered to lack the advantages of a discipline-focused education with its strong theoretical and methodological foundations. The problem this article addresses relates to how new generations of scholars and their views on knowledge creation achieve ascendancy in ways that move on from existing paradigms and earlier cohorts of scholars. Our main argument is that Generation Tourism scholars would benefit from a more clearly developed and common academic identity. To begin the critical conversation around the identity of Generation Tourism we outline five possible points of departure. These points are: (1) learning from historical developments in parent disciplines; (2) spearheading inter-disciplinary scholarship; (3) working towards theoretical developments; (4) embracing mediating methodologies and (5) forming tourism nodes and networks. Recognising these as starting points rather than final statements, we hope that the conversation about Generation Tourism identity will continue in other forums
Upper limits on the strength of periodic gravitational waves from PSR J1939+2134
The first science run of the LIGO and GEO gravitational wave detectors
presented the opportunity to test methods of searching for gravitational waves
from known pulsars. Here we present new direct upper limits on the strength of
waves from the pulsar PSR J1939+2134 using two independent analysis methods,
one in the frequency domain using frequentist statistics and one in the time
domain using Bayesian inference. Both methods show that the strain amplitude at
Earth from this pulsar is less than a few times .Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo
Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July
200
Improving the sensitivity to gravitational-wave sources by modifying the input-output optics of advanced interferometers
We study frequency dependent (FD) input-output schemes for signal-recycling
interferometers, the baseline design of Advanced LIGO and the current
configuration of GEO 600. Complementary to a recent proposal by Harms et al. to
use FD input squeezing and ordinary homodyne detection, we explore a scheme
which uses ordinary squeezed vacuum, but FD readout. Both schemes, which are
sub-optimal among all possible input-output schemes, provide a global noise
suppression by the power squeeze factor, while being realizable by using
detuned Fabry-Perot cavities as input/output filters. At high frequencies, the
two schemes are shown to be equivalent, while at low frequencies our scheme
gives better performance than that of Harms et al., and is nearly fully
optimal. We then study the sensitivity improvement achievable by these schemes
in Advanced LIGO era (with 30-m filter cavities and current estimates of
filter-mirror losses and thermal noise), for neutron star binary inspirals, and
for narrowband GW sources such as low-mass X-ray binaries and known radio
pulsars. Optical losses are shown to be a major obstacle for the actual
implementation of these techniques in Advanced LIGO. On time scales of
third-generation interferometers, like EURO/LIGO-III (~2012), with
kilometer-scale filter cavities, a signal-recycling interferometer with the FD
readout scheme explored in this paper can have performances comparable to
existing proposals. [abridged]Comment: Figs. 9 and 12 corrected; Appendix added for narrowband data analysi
Prevalence and Co-Occurrence of Actionable Genomic Alterations in High-Grade Bladder Cancer
We sought to define the prevalence and co-occurrence of actionable genomic alterations in patients with high-grade bladder cancer to serve as a platform for therapeutic drug discovery
Parastomal hernias after radical cystectomy and ileal conduit diversion
Parastomal hernia, defined as an “incisional hernia related to an abdominal wall stoma”, is a frequent complication after conduit
urinary diversion that can negatively impact quality of life and present a clinically significant problem for many patients. Parastomal
hernia (PH) rates may be as high as 65% and while many patients are asymptomatic, in some series up to 30% of patients
require surgical intervention due to pain, leakage, ostomy appliance problems, urinary obstruction, and rarely bowel obstruction
or strangulation. Local tissue repair, stoma relocation, and mesh repairs have been performed to correct PH, however, long-term
results have been disappointing with recurrence rates of 30%–76% reported after these techniques. Due to high recurrence rates
and the potential morbidity of PH repair, efforts have been made to prevent PH development at the time of the initial surgery. Randomized
trials of circumstomal prophylactic mesh placement at the time of colostomy and ileostomy stoma formation have shown
significant reductions in PH rates with acceptably low complication profiles. We have placed prophylactic mesh at the time of ileal
conduit creation in patients at high risk for PH development and found it to be safe and effective in reducing the PH rates over the
short-term. In this review, we describe the clinical and radiographic definitions of PH, the clinical impact and risk factors associated
with its development, and the use of prophylactic mesh placement for patients undergoing ileal conduit urinary diversion with the
intent of reducing PH rates
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Superficial and muscle-invasive bladder cancer: principles of management for outcomes assessments
Bladder cancer is a heterogeneous disease. Non-muscle-invasive bladder cancer embraces a spectrum of tumors with varying degrees of clinical behavior. Transurethral resection remains the surgical mainstay for the treatment of non-muscle-invasive bladder cancer. In an attempt to decrease the recurrence or progression rate, intravesical chemotherapy or immunotherapy is also used. Radical cystectomy with bilateral pelvic lymph node dissection remains the gold standard for treating muscle-invasive bladder cancer. Over the last decade, the orthotopic neobladder has gained widespread popularity as the preferred mode of urinary diversion in both males and females with similar oncologic and functional outcomes. Well-designed trials with effective chemotherapy have shown a beneficial role for neoadjuvant chemotherapy
Superficial and Muscle-Invasive Bladder Cancer: Principles of Management for Outcomes Assessments
Is lymphovascular invasion an important prognostic factor in patients with bladder cancer?
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