ROC curve of mHLA-DR expression slope (dash line) and IL-6 (full line) for predicting sepsis.

<p>Area under curves for mHLA-DR slope (days 3–4 /days 1–2) and IL-6 at days 1–2 were respectively .79 (95%CI .69; .88, p = .0001) and .75 (95%CI .64; .84, p = .0001). The best threshold was 1.1 for mHLA-DR ratio (sensitivity 82.6%, specificity 64.7%) and 67.1 pg/ml for IL-6 concentration (sensitivity 84.6% and specificity 72.5%).</p

Clinical patients’ characteristics.

<p>Parametric variables are expressed as mean ± standard deviation, and non-parametric variables as median (interquartile range) or frequencies.</p><p>*Independent samples t-test.</p>‡<p>Mann & Whitney test.</p>♦<p>Chi-square test</p><p>Abbreviations: ISS, Injury Severity Score; SAPS, Simple Acute Physiology Score; SOFA, Sequential Organ Failure Assessment; HLA, Human Leukocyte Antigen; ICU, Intensive Care Unit; D, day; IL, Interleukin.</p

Univariate logistic regression analysis according to the biologic test used to predict sepsis development.

<p>CI, confidence interval; D, days; IL, Interleukin; ISS, Injury Severity Score; mHLA-DR, monocyte human leukocyte antigen-DR; OR, odds ratio; SAPS II, Simple Acute Physiology Score II.</p

Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) for D3–4/D1–2 mHLA-DR, D1–2 IL-6 concentration, and the combination of D3–4/D1–2 mHLA-DR and D1–2 IL-6 concentration, for the diagnosis of sepsis during the intensive care unit (ICU) stay.

<p>Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) for D3–4/D1–2 mHLA-DR, D1–2 IL-6 concentration, and the combination of D3–4/D1–2 mHLA-DR and D1–2 IL-6 concentration, for the diagnosis of sepsis during the intensive care unit (ICU) stay.</p

Immunological patients’ characteristics.

<p>Parametric variables are expressed as mean ± standard deviation, and non-parametric variables as median (interquartile range) or frequencies.</p>*<p>Independent samples t-test.</p>‡<p>Mann & Whitney test.</p><p>Abbreviations: HLA, Human Leukocyte Antigen; D, day; IL, Interleukin.</p

Time course of IL-6 concentration in trauma patients, with (gray) or without (white bars) sepsis.

<p>Results (pg/ml) are expressed as median [interquartile range] (Mann & Whitney <i>U</i> test, * p<.01). At days 1–2, IL-6 concentration was significantly higher in septic patients than in non-septic patients, as at days 3–4 but with less significance.</p

Additional file 1: of Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes

Multivariate analysis for one-year mGFR. Comparison between NR and ISP groups with MANOVA analysis adjusting for age, gender, cold ischemia time and NR/ISP duration. (DOCX 48 kb

Additional file 1: of The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs

SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents*. (DOC 121 kb

Additional file 2: of The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs

World Health Organization Trial Registration Data Set*. (XLSX 10 kb

Additional file 3: of The ICU-Diary study: prospective, multicenter comparative study of the impact of an ICU diary on the wellbeing of patients and families in French ICUs

Participants’ centers. (DOCX 13 kb