Multivariate analysis for one-year mGFR. Comparison between NR and ISP groups with MANOVA analysis adjusting for age, gender, cold ischemia time and NR/ISP duration. (DOCX 48Â kb

Alexandre Faure (2175886)

Bernard Floccard (329581)

Claire Delsuc (4745163)

CĂŠcile Chauvet (4745175)

Didier Dorez (4745154)

Emmanuel Morelon (105212)

Guillaume Marcotte (1299150)

Julien Berthiller (4222345)

Lionel Badet (3580619)

Maud Rabeyrin (4347811)

Philip Robinson (17437)

Ricardo Codas (4745160)

Thomas RimmelĂŠ (4402894)

Vanessa Labeye (3580631)

Vannary Meas-Yedid (506609)

William Hanf (4745157)

Xavier Matillon (4745151)

BMC Nephrology

International audienceBackgroundKidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of ischemia/reperfusion injury during warm ischemia, normothermic recirculation recently replaced in situ perfusion prior to implantation in several institutions. The aim of this study was to compare these preservation methods on kidney graft outcomes.MethodsThe primary endpoint was the one-year measured graft filtration rate (mGFR). We collected retrospective data from 64 consecutive uDCD recipients transplanted over a seven-year period in a single centre.ResultsThirty-two grafts were preserved by in situ perfusion and 32 by normothermic recirculation. The mean ± SD mGFR at 1 year post-transplantation was 43.0 ± 12.8 mL/min/1.73 m2 in the in situ perfusion group and 53.2 ± 12.8 mL/min/1.73 m2 in the normothermic recirculation group (p = 0.01). Estimated GFR levels were significantly higher in the normothermic recirculation group at 12 months (p = 0.01) and 24 months (p = 0.03) of follow-up. We did not find any difference between groups regarding patient and graft survival, delayed graft function, graft rejection, or interstitial fibrosis.ConclusionsFunction of grafts preserved by normothermic recirculation was better at 1 year and the results suggest that this persists at 2 years, although no difference was found in short-term outcomes. Despite the retrospective design, this study provides an additional argument in favour of normothermic recirculation

Delsuc, Claire

Faure, Alexandre

Berthiller, Julien

Dorez, Didier

Matillon, Xavier

Meas-Yedid, Vannary

Floccard, Bernard

Marcotte, Guillaume

Labeye, Vanessa

Rabeyrin, Maud

Codas, Ricardo

Chauvet, Cécile

Robinson, Philip

Morelon, Emmanuel

Badet, Lionel

Hanf, William

Rimmelé, Thomas

HAL-HCL

Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes

FigShare

Additional file 1: of Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes

Hal-Diderot

Abstract Background Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of ischemia/reperfusion injury during warm ischemia, normothermic recirculation recently replaced in situ perfusion prior to implantation in several institutions. The aim of this study was to compare these preservation methods on kidney graft outcomes. Methods The primary endpoint was the one-year measured graft filtration rate (mGFR). We collected retrospective data from 64 consecutive uDCD recipients transplanted over a seven-year period in a single centre. Results Thirty-two grafts were preserved by in situ perfusion and 32 by normothermic recirculation. The mean ± SD mGFR at 1 year post-transplantation was 43.0 ± 12.8 mL/min/1.73 m2 in the in situ perfusion group and 53.2 ± 12.8 mL/min/1.73 m2 in the normothermic recirculation group (p = 0.01). Estimated GFR levels were significantly higher in the normothermic recirculation group at 12 months (p = 0.01) and 24 months (p = 0.03) of follow-up. We did not find any difference between groups regarding patient and graft survival, delayed graft function, graft rejection, or interstitial fibrosis. Conclusions Function of grafts preserved by normothermic recirculation was better at 1 year and the results suggest that this persists at 2 years, although no difference was found in short-term outcomes. Despite the retrospective design, this study provides an additional argument in favour of normothermic recirculation

Claire Delsuc

Alexandre Faure

Julien Berthiller

Didier Dorez

Xavier Matillon

Vannary Meas-Yedid

Bernard Floccard

Guillaume Marcotte

Vanessa Labeye

Maud Rabeyrin

Ricardo Codas

Cécile Chauvet

Philip Robinson

Emmanuel Morelon

Lionel Badet

William Hanf

Thomas Rimmelé

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https://figshare.com/articles/Additional_file_1_of_Uncontrolled_donation_after_circulatory_death_comparison_of_two_kidney_preservation_protocols_on_graft_outcomes/5768682

Additional file 1: of Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes

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