4,813 research outputs found
Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century.
In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas disease. More than two thousand children under the age of 14 have been treated; the majority of whom come from rural Latin American areas with difficult access. It is based on these lessons learnt, through mistakes and successes, that MSF advocates that medical care for patients with Chagas disease be a reality, in a manner which is inclusive (not exclusive), integrated (with medical, psychological, social, and educational components), and in which the patient is actively followed. This must be a multi-disease approach with permanent quality controls in place based on primary health care (PHC). Rapid diagnostic tests and new medications should be available, as well as therapeutic plans and patient management (including side effects) with standardised flows for medical care for patients within PHC in relation to secondary and tertiary level, inclusive of epidemiological surveillance systems
Phase II of the ASCE Benchmark Study on SHM
The task group on structural health monitoring of the Dynamic Committee of ASCE was formed in
1999 at the 12
th
Engineering Mechanics Conference. The task group has designed a number of analytical
studies on a benchmark structure and there are plans to follow these with an experimental program. The
first phase of the analytical studies was completed in 2001. The second phase, initiated in the summer of
2001, was formulated in the light of the experience gained on phase I and focuses on increasing realism in
the simulation of the discrepancies between the actual structure and the mathematical model used in the
analysis. This paper describes the rational that lead the SHM task group to the definition of phase II and
presents the details of the cases that are being considered
Interference pattern in the collision of structures in the BEC dark matter model: comparison with fluids
In order to explore nonlinear effects on the distribution of matter during
collisions within the Bose-Einstein condensate (BEC) dark matter model driven
by the Schr\"odinger-Poisson system of equations, we study the head-on
collision of structures and focus on the interference pattern formation in the
density of matter during the collision process. We explore the possibility that
the collision of two structures of fluid matter modeled with an ideal gas
equation of state also forms interference patterns and found a negative result.
Given that a fluid is the most common flavor of dark matter models, we conclude
that one fingerprint of the BEC dark matter model is the pattern formation in
the density during a collision of structures.Comment: 7 pages, 22 eps figure
The Jahn-Teller active fluoroperovskites : thermo- and magneto optical correlations as function of the -site
Chromium (II) fluoroperovskites are
strongly correlated Jahn-Teller active materials at low temperatures. In this
paper, we examine the role that the -site ion plays in this family of
fluoroperovskites using both experimental methods (XRD, optical absorption
spectroscopy and magnetic fields) and DFT simulations. Temperature-dependent
optical absorption experiments show that the spin-allowed transitions and
only merge completely for = Na at 2 K. Field-dependent optical
absorption measurements at 2 K show that the oscillating strength of the
spin-allowed transitions in increases with increasing
applied field. Direct magneto-structural correlations which suppress the
spin-flip transitions are observed for below its Ne\'el
temperature. In the spin-flip transitions vanish abruptly below
9 K revealing magneto-optical correlations not linked to crystal structure
changes. This suggests that as the long range ordering is reduced local JT
effects in the individual octahedra take control of the
observed behavior. Our results show clear deviation from the pattern found for
the isoelectronic system. The size of the -site cation
is shown to be central in dictating the physical properties and phase
transitions in , opening up the possibility of varying the
composition to create novel states of matter with tuneable properties
Epitaxial Frustration in Deposited Packings of Rigid Disks and Spheres
We use numerical simulation to investigate and analyze the way that rigid
disks and spheres arrange themselves when compressed next to incommensurate
substrates. For disks, a movable set is pressed into a jammed state against an
ordered fixed line of larger disks, where the diameter ratio of movable to
fixed disks is 0.8. The corresponding diameter ratio for the sphere simulations
is 0.7, where the fixed substrate has the structure of a (001) plane of a
face-centered cubic array. Results obtained for both disks and spheres exhibit
various forms of density-reducing packing frustration next to the
incommensurate substrate, including some cases displaying disorder that extends
far from the substrate. The disk system calculations strongly suggest that the
most efficient (highest density) packings involve configurations that are
periodic in the lateral direction parallel to the substrate, with substantial
geometric disruption only occurring near the substrate. Some evidence has also
emerged suggesting that for the sphere systems a corresponding structure doubly
periodic in the lateral directions would yield the highest packing density;
however all of the sphere simulations completed thus far produced some residual
"bulk" disorder not obviously resulting from substrate mismatch. In view of the
fact that the cases studied here represent only a small subset of all that
eventually deserve attention, we end with discussion of the directions in which
first extensions of the present simulations might profitably be pursued.Comment: 28 pages, 14 figures; typos fixed; a sentence added to 4th paragraph
of sect 5 in responce to a referee's comment
Scalar Field Dark Matter: head-on interaction between two structures
In this manuscript we track the evolution of a system consisting of two
self-gravitating virialized objects made of a scalar field in the newtonian
limit. The Schr\"odinger-Poisson system contains a potential with
self-interaction of the Gross-Pitaevskii type for Bose Condensates. Our results
indicate that solitonic behavior is allowed in the scalar field dark matter
model when the total energy of the system is positive, that is, the two blobs
pass through each other as should happen for solitons; on the other hand, there
is a true collision of the two blobs when the total energy is negative.Comment: 8 revtex pages, 11 eps figures. v2 matches the published version.
v2=v1+ref+minor_change
Dynamical Arrest in Attractive Colloids: The Effect of Long-Range Repulsion
We study gelation in suspensions of model colloidal particles with
short-ranged attractive and long-ranged repulsive interactions by means of
three-dimensional fluorescence confocal microscopy. At low packing fractions,
particles form stable equilibrium clusters. Upon increasing the packing
fraction the clusters grow in size and become increasingly anisotropic until
finally associating into a fully connected network at gelation. We find a
surprising order in the gel structure. Analysis of spatial and orientational
correlations reveals that the gel is composed of dense chains of particles
constructed from face-sharing tetrahedral clusters. Our findings imply that
dynamical arrest occurs via cluster growth and association.Comment: Final version: Phys. Rev. Lett. 94, 208301 (2005
A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum
Proteomics data can supplement genome annotation efforts, for example being used to confirm gene models or correct gene annotation errors. Here, we present a large‐scale proteogenomics study of two important apicomplexan pathogens: Toxoplasma gondii and Neospora caninum. We queried proteomics data against a panel of official and alternate gene models generated directly from RNASeq data, using several newly generated and some previously published MS datasets for this meta‐analysis. We identified a total of 201 996 and 39 953 peptide‐spectrum matches for T. gondii and N. caninum, respectively, at a 1% peptide FDR threshold. This equated to the identification of 30 494 distinct peptide sequences and 2921 proteins (matches to official gene models) for T. gondii, and 8911 peptides/1273 proteins for N. caninum following stringent protein‐level thresholding. We have also identified 289 and 140 loci for T. gondii and N. caninum, respectively, which mapped to RNA‐Seq‐derived gene models used in our analysis and apparently absent from the official annotation (release 10 from EuPathDB) of these species. We present several examples in our study where the RNA‐Seq evidence can help in correction of the current gene model and can help in discovery of potential new genes
- …