The Distributed Text: An Annotated Digital Edition of Franz Boas’ Pioneering Ethnography

Under the rubric of a new Franz Boas Critical Edition book series, we propose to reprint and annotate Boas's important 1897 monograph The Social Organization and the Secret Societies of the Kwakiutl Indians in both print and as a multimedia website. Framed with scholarly essays and contemporary Kwakwaka'wakw perspectives, the new editions will re-unite the original text with widely distributed archival and museum collections that shed new light on the book. This project will reveal the nature of co-authorship in Boas's work, use multimedia to return sensory richness to his ethnography, and make this historic research more relevant to contemporary scholars and indigenous communities. The Digital Humanities Start Up Grant (level II) will be used to fund a workshop to plan the digital edition; for design of a wiki for collaborative research; for travel to determine the full range of materials to be digitized; for production of sample webpages to test interfaces and functionality; for salary toward project administration and digital technology assistance; and for development of innovative software to reproduce and render searchable the large amounts of Kwakw'ala-language materials

How Personalized Networks Can Limit Free Riding: A Multi-Group Version of the Public Goods Game

People belong to many different groups, and few belong to the same network of groups. Moreover, people routinely reduce their involvement in dysfunctional groups while increasing involvement in those they find more attractive. The net effect can be an increase in overall cooperation and the partial isolation of free-riders, even if free-riders are never punished, excluded, or recognized. We formalize and test this conjecture with an agent-based social simulation and a multi-good extension of the standard repeated public goods game. Our initial results from three treatments suggest that the multi-group setting indeed raises overall cooperation and dampens the impact of freeriders. We extend our understanding of this setting by imposing greater heterogeneity between groups through interweaving automated bot players amongst human subjects; whereby initial sessions of this amplify the aforementioned effects

Radiation-induced Acoustic Loss in Quartz Crystals

Physic

Reorganizing The Social Organization: Collaborative Editing, Museum Collections, Indigenous Knowledges, and the Franz Boas/George Hunt Archives

Franz Boas's 1897 report, The Social Organization and the Secret Societies of the Kwakiutl Indians, was a landmark in anthropology for its integrative approach to museum collections, photographs, and sound recordings as well as text. A result of participant observation and extensive collaboration with Indigenous partners—especially George Hunt—the book set a standard for both ethnography and museum practice. However, both Boas and Hunt remained dissatisfied with the published text, laboring for decades to correct and supplement a volume that would forever mediate global knowledge of the Kwakwaka’wakw people of British Columbia. They left behind a vast archive of unpublished materials relevant to the creation and afterlife of this groundbreaking text and its related museum collections. These materials are now widely distributed across institutional, disciplinary, and international borders. This paper will discuss an ongoing collaborative project to create a multimedia, web-based critical edition of the book that reassembles published and unpublished materials as well as Kwakwaka’wakw knowledge. Archival revelations about the truly co-authored nature of the original text allow us to better situate the contexts and methods of creating ethnographic knowledge in relation to the Indigenous ontologies that The Social Organization purports to represent. Moreover, the edition seeks to demonstrate ways in which digital technologies can harness multimedia to return sensory richness to Boas and Hunt’s synthetic text, to reactivate disparate and long dormant museum collections, and to restore cultural patrimony to its Indigenous inheritors

Monoclonal Antibodies to the V2 Domain of MN-rgp120: Fine Mapping of Epitopes and Inhibition of α4β7 Binding

BACKGROUND: Recombinant gp120 (MN-rgp120) was a major component of the AIDSVAX B/E vaccine used in the RV144 trial. This was the first clinical trial to show that vaccination could prevent HIV infection in humans. A recent RV144 correlates of protection study found that protection correlated with the presence of antibodies to the V2 domain. It has been proposed that antibodies to the α4β7 binding site in the V2 domain might prevent HIV-1 infection by blocking the ability of virions to recognize α4β7 on activated T-cells. In this study we investigated the specificity of monoclonal antibodies (MAbs) to the V2 domain of MN-rgp120 and examined the possibility that these antibodies could inhibit the binding of MN-rgp120 to the α4β7 integrin. METHODOLOGY/PRINCIPAL FINDINGS: Nine MAbs to the V2 domain were isolated from mice immunized with recombinant envelope proteins. The ability of these MAbs to inhibit HIV infection, block the binding of gp120 to CD4, and block the binding of MN-rgp120 to the α4β7 integrin was measured. Mutational analysis showed that eight of the MAbs recognized two immunodominant clusters of amino acids (166-168 and 178-183) located at either end of the C strand within the four-strand anti-parallel sheet structure comprising the V1/V2 domain. CONCLUSIONS/SIGNIFICANCE: These studies showed that the antigenic structure of the V2 domain is exceedingly complex and that MAbs isolated from mice immunized with MN-rgp120 exhibited a high level of strain specificity compared to MAbs to the V2 domain isolated from HIV-infected humans. We found that immunization with MN-rgp120 readily elicits antibodies to the V2 domain and some of these were able to block the binding of MN-rgp120 to the α4β7 integrin

Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis

<p>Abstract</p> <p>Background</p> <p>Perivenular inflammation is a common early pathological feature in multiple sclerosis (MS). A recent hypothesis stated that CNS inflammation is induced by perivenular iron deposits that occur in response to altered blood flow in MS subjects. In order to evaluate this hypothesis, an animal model was developed, called cerebral experimental autoimmune encephalomyelitis (cEAE), which presents with CNS perivascular iron deposits. This model was used to investigate the relationship of iron deposition to inflammation.</p> <p>Methods</p> <p>In order to generate cEAE, mice were given an encephalitogen injection followed by a stereotactic intracerebral injection of TNF-α and IFN-γ. Control animals received encephalitogen followed by an intracerebral injection of saline, or no encephalitogen plus an intracerebral injection of saline or cytokines. Laser Doppler was used to measure cerebral blood flow. MRI and iron histochemistry were used to localize iron deposits. Additional histological procedures were used to localize inflammatory cell infiltrates, microgliosis and astrogliosis.</p> <p>Results</p> <p>Doppler analysis revealed that cEAE mice had a reduction in cerebral blood flow compared to controls. MRI revealed T2 hypointense areas in cEAE animals that spatially correlated with iron deposition around vessels and at some sites of inflammation as detected by iron histochemistry. Vessels with associated iron deposits were distributed across both hemispheres. Mice with cEAE had more iron-labeled vessels compared to controls, but these vessels were not commonly associated with inflammatory cell infiltrates. Some iron-laden vessels had associated microgliosis that was above the background microglial response, and iron deposits were observed within reactive microglia. Vessels with associated astrogliosis were more commonly observed without colocalization of iron deposits.</p> <p>Conclusion</p> <p>The findings indicate that iron deposition around vessels can occur independently of inflammation providing evidence against the hypothesis that iron deposits account for inflammatory cell infiltrates observed in MS.</p

Balloon dilation of mitral stenosis in adult patients: Postmortem and percutaneous mitral valvuloplasty studies

Preliminary reports have documented the utility of percutaneous balloon valvuloplasty of the mitral valve in adult patients with mitral stenosis, but the mechanism of successful valve dilation and the effect of mitral valvuloplasty on cardiac performance have not been studied in detail. Accordingly, mitral valvuloplasty was performed in five postmortem specimens and in 18 adult patients with rheumatic mitral stenosis, using either one (25 mm) or two (18 and 20 mm) dilation balloons. Postmortem balloon dilation resulted in increased valve orifice area in all five postmortem specimens, secondary to separation of fused commissures and fracture of nodular calcium within the mitral leaflets. In no case did balloon dilation result in tearing of valve leaflets, disruption of the mitral ring or liberation of potentially embolic debris.Percutaneous mitral valvuloplasty in 18 patients with severe mitral stenosis (including 9 with a heavily calcified valve) resulted in an increase in cardiac output (4.3 ± 1.1 to 5.1 ± 1.5 liters/min, p < 0.01) and mitral valve area (0.9 ± 0.2 to 1.6 ± 0.4 cm2, p < 0.0001), and a decrease in mean mitral pressure gradient (15 ± 5 to 9 ± 4 mm Hg, p < 0.0001), pulmonary capillary wedge pressure (23 ± 7 to 18 ± 7 mm Hg, p < 0.0001) and mean pulmonary artery pressure (36 ± 12 to 33 ± 12 mm Hg, p < 0.01). Left ventriculography before and after valvuloplasty in 14 of the 18 patients showed a mild (≤1 +) increase in mitral regurgitation in five patients and no change in the remainder. Embolic phenomena were not observed in any patient.Serial radionuclide ventriculography showed an increase in left ventricular peak filling rate (2.20 ± 1.20 to 2.50 ± 1.20 end-diastolic volumes per second [EDV/s], p < 0.05). Serial echocardiography/phonocardiography showed improvement in mitral valve excursion (11 ± 6 to 14 ± 6 mm, p < 0.001), mitral EF slope (7 ± 4 to 13 ± 5, p < 0.001), left atrial diameter (5.7 ± 0.9 to 5.3 ± 0.8 cm, p < 0.001), S2-opening snap interval (0.07 ± 0.03 to 0.08 ± 0.02 second, p < 0.02) and mitral valve area (0.9 ± 0.2 to 1.5 ± 0.4 cm2, p < 0.0001). All patients were discharged from the hospital with de- creased symptoms after valvuloplasty.It is concluded that percutaneous mitral valvuloplasty can be performed in adult patients with mitral stenosis, including patients with calcific disease, and can result in significant improvement in valvular function. The mechanisms of successful dilation include commissural separation and fracture of nodular calcium

Single-Electron Spectroscopy

Contains research goals and objectives, reports on four research projects and a list of publications.David and Lucille Packard FoundationJoint Services Electronics Program Grant DAAH04-95-1-0038U.S. Navy - Office of Naval Research Grant N00014-93-1-0633National Science Foundation Young Investigator Awar