8,640 research outputs found
Involuntary And Patient-Initiated Delays In Medical Care During The COVID-19 Pandemic
This paper uses data from a new, nationally representative survey to study delays in non–COVID-related medical care among US adults during the COVID-19 pandemic. We expand on prior research by taking a comprehensive look at the many reasons patients may have experienced delays in medical care and by studying the longer-run implications of these delays for patients’ self-reported health, use of telemedicine, feelings of regret, and likelihood of delaying care again in the future. Classifying delays in care broadly as involuntary (those due to availability or “supply-side” constraints) or patient-initiated (those due to patient concerns or “demand-side” constraints), we document important differences across demographic groups in the propensity to delay care for these reasons. In contrast to most prior work on this topic, our analyses can disentangle differences in the likelihood of delaying care from differences in pre-pandemic care-seeking behavior. We also demonstrate that the types of medical care that were delayed during the pandemic differed based on whether the delay was involuntary or patient-initiated, as did the duration of the delays and their associations with self-reported health, telemedicine use, and feelings of regret
Fluctuation superconductivity limited noise in a transition-edge sensor
In order to investigate the origin of the until now unaccounted excess noise
and to minimize the uncontrollable phenomena at the transition in X-ray
microcalorimeters we have developed superconducting transition-edge sensors
into an edgeless geometry, the so-called Corbino disk (CorTES), with
superconducting contacts in the centre and at the outer perimeter. The measured
rms current noise and its spectral density can be modeled as resistance noise
resulting from fluctuations near the equilibrium superconductor-normal metal
boundaryComment: 9 pages, 4 figures.; Corrections to text and equations; replaced the
affected figures. Added reference [12
The Gelfand map and symmetric products
If A is an algebra of functions on X, there are many cases when X can be
regarded as included in Hom(A,C) as the set of ring homomorphisms. In this
paper the corresponding results for the symmetric products of X are introduced.
It is shown that the symmetric product Sym^n(X) is included in Hom(A,C) as the
set of those functions that satisfy equations generalising f(xy)=f(x)f(y).
These equations are related to formulae introduced by Frobenius and, for the
relevant A, they characterise linear maps on A that are the sum of ring
homomorphisms. The main theorem is proved using an identity satisfied by
partitions of finite sets.Comment: 14 pages, Late
De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis
Multiple genes involved in endocytosis and endosomal protein trafficking in Drosophila have been shown to function as neoplastic tumor suppressor genes (nTSGs), including Endosomal Sorting Complex Required for Transport-II (ESCRT-II) components vacuolar protein sorting 22 (vps22), vps25, and vps36. However, most studies of endocytic nTSGs have been done in mosaic tissues containing both mutant and non-mutant populations of cells, and interactions among mutant and non-mutant cells greatly influence the final phenotype. Thus, the true autonomous phenotype of tissues mutant for endocytic nTSGs remains unclear. Here, we show that tissues predominantly mutant for ESCRT-II components display characteristics of neoplastic transformation and then undergo apoptosis. These neoplastic tissues show upregulation of c-Jun N-terminal Kinase (JNK), Notch, and Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling. Significantly, while inhibition of JNK signaling in mutant tissues partially inhibits proliferation, inhibition of JAK/STAT signaling rescues other aspects of the neoplastic phenotype. This is the first rigorous study of tissues predominantly mutant for endocytic nTSGs and provides clear evidence for cooperation among de-regulated signaling pathways leading to tumorigenesis
An Atlas of the circumnuclear regions of 75 Seyfert galaxies in the near-UV with HST Advanced Camera for Surveys
We present an atlas of the central regions of 75 Seyfert galaxies imaged in
the near-UV with the Advanced Camera for Surveys of the Hubble Space Telescope
at an average resolution of ~10pc. These data complement archival high
resolution data from the Space Telescope at optical and near-IR wavelengths,
creating an extremely valuable dataset for astronomers with a broad range of
scientific interests. Our goal is to investigate the nature of the near-UV
light in these objects, its relation to the circumnuclear starburst phenomenon,
and the connection of this to the evolution and growth of the galaxy bulge and
central black hole. In this paper, we describe the near-UV morphology of the
objects and characterize the near-UV emission. We estimate the size and the
luminosity of the emitting regions and extract the luminosity profile. We also
determine the presence of unresolved compact nuclei. In addition, the
circumnuclear stellar cluster population is identified, and the contribution of
the stellar clusters to the total light, at this wavelength, is estimated. The
size of the sample allows us to draw robust statistical conclusions. We find
that {Seyfert 1} galaxies are completely dominated by its bright and compact
nucleus, that remains point-like at this resolution, while we find almost no
unresolved nucleus in Seyfert 2. The Seyfert types 1 and 2 are quite segregated
in an asymmetry vs compactness plot. Stellar clusters are found somewhat more
frequently in Sy2 (in ~70% of the galaxies) than in Sy1 (~57%), and contribute
more to the total light in Sy2, but this two differences seem to be mostly due
to the large contribution of the compact nucleus in Sy1, as the luminosity
distribution of the clusters is similar in both Sy types.Comment: Accepted for publication in AJ, 58 pages, 20 figures. High-resolution
figures for all the objects are available at
http://www.iaa.es/~manuel/publications/paper01.htm
Passage of an integral membrane protein, the vesicular stomatitis virus glycoprotein, through the Golgi apparatus en route to the plasma membrane.
Measuring the Density Matrix by Local Addressing
We introduce a procedure to measure the density matrix of a material system.
The density matrix is addressed locally in this scheme by applying a sequence
of delayed light pulses. The procedure is based on the stimulated Raman
adiabatic passage (STIRAP) technique. It is shown that a series of population
measurements on the target state of the population transfer process yields
unambiguous information about the populations and coherences of the addressed
states, which therefore can be determined.Comment: 4 pages, 1 figur
Lagrangian approach to a symplectic formalism for singular systems
We develop a Lagrangian approach for constructing a symplectic structure for
singular systems. It gives a simple and unified framework for understanding the
origin of the pathologies that appear in the Dirac-Bergmann formalism, and
offers a more general approach for a symplectic formalism, even when there is
no Hamiltonian in a canonical sense. We can thus overcome the usual limitations
of the canonical quantization, and perform an algebraically consistent
quantization for a more general set of Lagrangian systems.Comment: 30 page
Modeling self-organization of communication and topology in social networks
This paper introduces a model of self-organization between communication and
topology in social networks, with a feedback between different communication
habits and the topology. To study this feedback, we let agents communicate to
build a perception of a network and use this information to create strategic
links. We observe a narrow distribution of links when the communication is low
and a system with a broad distribution of links when the communication is high.
We also analyze the outcome of chatting, cheating, and lying, as strategies to
get better access to information in the network. Chatting, although only
adopted by a few agents, gives a global gain in the system. Contrary, a global
loss is inevitable in a system with too many liarsComment: 6 pages 7 figures, Java simulation available at
http://cmol.nbi.dk/models/inforew/inforew.htm
- …