A Visual Language for Web Querying and Reasoning

As XML is increasingly being used to represent information on the Web, query and reasoning languages for such data are needed. This article argues that in contrast to the navigational approach taken in particular by XPath and XQuery, a positional approach as used in the language Xcerpt is better suited for a straightforward visual representation. The constructs of the pattern- and rule-based query language Xcerpt are introduced and it is shown how the visual representation visXcerpt renders these constructs to form a visual query language for XML

Development of a risk classification model in early pregnancy to screen for suboptimal postnatal mother-to-infant bonding:A prospective cohort study

BACKGROUND: Previous studies identified demographic, reproduction-related and psychosocial correlates of suboptimal mother-to-infant bonding. Their joint informative value was still unknown. This study aimed to develop a multivariable model to screen early in pregnancy for suboptimal postnatal mother-to-infant bonding and to transform it into a risk classification model. METHODS: Prospective cohort study conducted at 116 midwifery centers between 2010-2014. 634 women reported on the Mother-to-Infant Bonding questionnaire in 2015-2016. A broad range of determinants before 13 weeks of gestation were considered. Missing data were described, analyzed and imputed by multiple imputation. Multivariable logistic regression with backward elimination was used to develop a screening model. The explained variance, the Area Under the Curve of the final model were calculated and a Hosmer and Lemeshow test performed. Finally, we designed a risk classification model. RESULTS: The prevalence of suboptimal mother-to-infant bonding was 11%. The estimated probability of suboptimal mother-to-infant can be calculated: P(MIBS≥4) = 1/(1+exp(-(-4.391+(parity× 0.519)+(Adult attachment avoidance score× 0.040))). The explained variance was 14% and the Area Under the Curve was 0.750 (95%CI 0.690-0.809). The Hosmer and Lemeshow test had a p-value of 0.21. This resulted in a risk classification model. CONCLUSION: Parity and adult attachment avoidance were the strongest independent determinants. Higher parity and higher levels of adult attachment avoidance are associated with an increased risk of suboptimal mother-to-infant bonding. The model and risk classification model should be externally validated and optimized before use in daily practice. Future research should include an external validation study, a study into the additional value of non-included determinants and finally a study on the impact and feasibility of the screening model

Cancer research in need of a scientific revolution: Using 'paradigm shift' as a method of investigation.

International audienceDespite important human and financial resources and considerable accumulation of scientific publications, patents, and clinical trials, cancer research has been slow in achieving a therapeutic revolution similar to the one that occurred in the last century for infectious diseases. It has been proposed that science proceeds not only by accumulating data but also through paradigm shifts. Here, we propose to use the concept of 'paradigm shift' as a method of investigation when dominant paradigms fail to achieve their promises. The first step in using the 'paradigm shift' method in cancer research requires identifying its founding paradigms. In this review, two of these founding paradigms will be discussed: (i) the reification of cancer as a tumour mass and (ii) the translation of the concepts issued from infectious disease in cancer research. We show how these founding paradigms can generate biases that lead to over-diagnosis and over-treatment and also hamper the development of curative cancer therapies. We apply the 'paradigm shift' method to produce perspective reversals consistent with current experimental evidence. The 'paradigm shift' method enlightens the existence of a tumour physiologic-prophylactic-pathologic continuum. It integrates the target/antitarget concept and that cancer is also an extracellular disease. The 'paradigm shift' method has immediate implications for cancer prevention and therapy. It could be a general method of investigation for other diseases awaiting therap

Characterisation of human glioma resections by Fast Field-Cycling NMR

abstract 58Peer reviewedPublisher PD

X-FCSR: a new software oriented stream cipher based upon FCSRs

Feedback with Carry Shift Registers (FCSRs) are a promising alternative to LFSRs in the design of stream cipher. The previous constructions based on FCSRs were dedicated to hardware applications. In this paper, we will describe X-FCSR a family of software oriented stream cipher using FCSRs. The core of the system is composed of two 256-bits FCSRs. We propose two versions: X-FCSR-128 and X-FCSR-256 which output respectively 128 and 256 bits at each iteration. We study the resistance of our design against several cryptanalyses. In this way, we achieve a high throughput and secure stream ciphers suitable for software applications (6.3 cycles/byte)

Cost-effectiveness of CTC guided chemo- or endocrine therapy in ER+ HER2- metastatic breast cancer – results from a randomized controlled multicenter trial

Patients with metastatic, Estrogen Receptor (ER) positive, HER2-negative, breast cancer, before initiating CDK4/6 inhibitors, receive either single agent endocrine- or chemotherapy based on their clinical risk. In this first-ever trial-based economic evaluation of Circulating Tumor Cells (CTCs), the cost-effectiveness of standardizing the prescription of endocrine- or chemotherapy using a CTC count threshold (with >5 CTCs/7.5mL indicative of unfavorable disease outcomes) was compared to current clinical practice. N=755 ER+ HER2-patients, enrolled in 17 French centres, were randomized to CTC guided or standard of care and were treated according to either through the CTC score or clinical examination. Health state utilities were calculated by mapping the QLQ-C30 to EQ-5D utilities and used to calculate Quality-Adjusted Life Years (QALY) over a 2-year time horizon. Bootstrapping and additional sensitivity analyses were performed to quantify the impact of uncertainty. Health outcomes in both arms were similar, but costs were higher in the CTC guided arm (€19,403) compared to the usual care (€18,254), resulting in an ICER of €104,078/QALY in favor of usual care. However, when the analysis was performed for the clinically high- and low-risk groups separately, CTC enumeration could be a dominant strategy (cost saving) if treatment is de-escalated in clinically high-risk patients as indicated by CTC scores. However, the current analysis was based on the PFS and OS data reported in 2021 and long-term Overall Survival data is collected since then (JCO, 2023 in press). A further analysis of the health economic impact of CTC enumeration in clinically low and high-risk groups is therefore indicated

Analysis of human glioma by FFC NMR

Non peer reviewedPublisher PD

Role of transmembrane water exchange in glioma invasion/migration : in vivo preclinical study by relaxometry at very low magnetic field

Funding: This project received funding from the European Union Horizon 2020 research and innovation program under grant agreement No 668119 (project IDentIFY). The Italian Ministry for Education and Research (MIUR) is gratefully acknowledged for yearly FOE funding to the EuroBioImaging Multi-Modal Molecular Imaging Italian Node (MMMI). Maria Rosaria Ruggiero was supported by an “FIRC-AIRC fellowship for Italy” and benefited from a COST Action grant (AC15209—EURELAX) to perform first IHC analysis at BrainTech Lab. Acknowledgments: The authors thank the zootechnicians of the Clinatec animal facility led by Diane Agay for their assistance in animal management, and Reda Manyani, a master student, for his contribution to confirm IHC data analysis, first performed by the author Hamza Ait Itto.Peer reviewedPublisher PD