High velocity spikes in Gowdy spacetimes

We study the behavior of spiky features in Gowdy spacetimes. Spikes with velocity initially high are, generally, driven to low velocity. Let n be any integer greater than or equal to 1. If the initial velocity of an upward pointing spike is between 4n-3 and 4n-1 the spike persists with final velocity between 1 and 2, while if the initial velocity is between 4n-1 and 4n+1, the spiky feature eventually disappears. For downward pointing spikes the analogous rule is that spikes with initial velocity between 4n-4 and 4n-2 persist with final velocity between 0 and 1, while spikes with initial velocity between 4n-2 and 4n eventually disappear.Comment: discussion of constraints added. Accepted for publication in Phys. Rev.

Harmonic coordinate method for simulating generic singularities

This paper presents both a numerical method for general relativity and an application of that method. The method involves the use of harmonic coordinates in a 3+1 code to evolve the Einstein equations with scalar field matter. In such coordinates, the terms in Einstein's equations with the highest number of derivatives take a form similar to that of the wave equation. The application is an exploration of the generic approach to the singularity for this type of matter. The preliminary results indicate that the dynamics as one approaches the singularity is locally the dynamics of the Kasner spacetimes.Comment: 5 pages, 4 figures, Revtex, discussion expanded, references adde

Increased Yield of ttbb at Hadron Colliders in Low-Energy Supersymmetry

Light bottom squarks and gluinos have been invoked to explain the b quark pair production excess at the Tevatron. We investigate the associated production of ttbb at hadron colliders in this scenario, and find that the rates for this process are enhanced over the Standard Model prediction. If light gluinos exist, it may be possible to detect them at the Tevatron, and they could easily be observed at the LHC.Comment: 5p, references added, version accepted to PR

Numerical evolution of Brill waves

We report a numerical evolution of axisymmetric Brill waves. The numerical algorithm has new features, including (i) a method for keeping the metric regular on the axis and (ii) the use of coordinates that bring spatial infinity to the edge of the computational grid. The dependence of the evolved metric on both the amplitude and shape of the initial data is found.Comment: added more discussion of results and several reference

The Membership and Distance of the Open Cluster Collinder 419

The young open cluster Collinder 419 surrounds the massive O star, HD 193322, that is itself a remarkable multiple star system containing at least four components. Here we present a discussion of the cluster distance based upon new spectral classifications of the brighter members, UBV photometry, and an analysis of astrometric and photometric data from the UCAC3 and 2MASS catalogs. We determine an average cluster reddening of E(B-V)=0.37 +- 0.05 mag and a cluster distance of 741 +- 36 pc. The cluster probably contains some very young stars that may include a reddened M3 III star, IRAS~20161+4035

Slow movement of a random walk on the range of a random walk in the presence of an external field

In this article, a localisation result is proved for the biased random walk on the range of a simple random walk in high dimensions (d \geq 5). This demonstrates that, unlike in the supercritical percolation setting, a slowdown effect occurs as soon a non-trivial bias is introduced. The proof applies a decomposition of the underlying simple random walk path at its cut-times to relate the associated biased random walk to a one-dimensional random walk in a random environment in Sinai's regime

Apical Ballooning Syndrome: A Complication of Dual Chamber Pacemaker Implantation

Apical ballooning is a cardiac syndrome (Takotsubo Cardiomyopathy) described as a typical form of acute transient left ventricular dysfunction. While its onset has often been associated with emotionally or physically stressful situations, it has an overall favorable prognosis. We describe here a case of transient apical ballooning following permanent pacemaker implantation

A programme for risk assessment and minimisation of progressive multifocal leukoencephalopathy developed for vedolizumab clinical trials

Introduction Over the past decade, the potential for drug-associated progressive multifocal leukoencephalopathy (PML) has become an increasingly important consideration in certain drug development programmes, particularly those of immunomodulatory biologics. Whether the risk of PML with an investigational agent is proven (e.g. extrapolated from relevant experience, such as a class effect) or merely theoretical, the serious consequences of acquiring PML require careful risk minimisation and assessment. No single standard for such risk minimisation exists. Vedolizumab is a recently developed monoclonal antibody to α4β7 integrin. Its clinical development necessitated a dedicated PML risk minimisation assessment as part of a global preapproval regulatory requirement. Objective The aim of this study was to describe the multiple risk minimisation elements that were incorporated in vedolizumab clinical trials in inflammatory bowel disease patients as part of the risk assessment and minimisation of PML programme for vedolizumab. Methods A case evaluation algorithm was developed for sequential screening and diagnostic evaluation of subjects who met criteria that indicated a clinical suspicion of PML. An Independent Adjudication Committee provided an independent, unbiased opinion regarding the likelihood of PML. Results Although no cases were detected, all suspected PML events were thoroughly reviewed and successfully adjudicated, making it unlikely that cases were missed. Conclusion We suggest that this programme could serve as a model for pragmatic screening for PML during the clinical development of new drugs

First direct observation of a nearly ideal graphene band structure

Angle-resolved photoemission and X-ray diffraction experiments show that multilayer epitaxial graphene grown on the SiC(000-1) surface is a new form of carbon that is composed of effectively isolated graphene sheets. The unique rotational stacking of these films cause adjacent graphene layers to electronically decouple leading to a set of nearly independent linearly dispersing bands (Dirac cones) at the graphene K-point. Each cone corresponds to an individual macro-scale graphene sheet in a multilayer stack where AB-stacked sheets can be considered as low density faults.Comment: 5 pages, 4 figure