The Two Media Literacies: A Cultural Studies Perspective

This analysis identifies the problem of the media saturation of people’s lives as a reason for developing programs teaching media literacy. It argues that the basic or foundational disciplines found in cultural studies, such as applied semiotics, psychoanalytic theory, sociological theory, and Marxist analysis, are the proper way to teach media criticism and media literacy (See Berger, A.A., Media Analysis Techniques, 6th edition, 2019). The methods by themselves are not adequate, which means that teaching media literacy also involves providing exercises and learning games that show students how to apply the theories they learn to their analyses of media texts (See Berger, A.A., Games and Activities for Media, Communication, and Cultural Studies Students,2004). Finally, it is suggested that media literacy should be taught at all educational levels

O Brave New World: The Dark Side of Cyberspace

This article focuses on some of the negative aspects of cyberspace and cyberculture. First, it offers an examination of the impact of our use of social media, and Facebook in particular, on our psyches, pointing out that users of social media can be thought of as audiences. These audiences and information about them can be sold to marketers and advertisers. Next, it offers a case study of a widespread social problem in Japan, more than a million media-obsessed Japanese young men (and some young women), the hikikomori, who shut themselves off from society for months or years at a time. This is followed by a discussion of the impact of mobiles, primarily smartphones, on American adolescents, some of whom text one hundred messages a day to their friends. The effects of the enormous amount of face-time young people spend with screens - around ten hours per day - are also considered. Finally, there is an examination of the impact that Amazon.com, the leading e-commerce Internet site, has had on American shopping practices and American culture and society. The article concludes with a discussion of the work of Hubert Dreyfus about some negative effects of the Internet and, by implication, cyberspace and cyberculture, which, he argues, drain life of meaning

O Brave New World: The Dark Side of Cyberspace

This article focuses on some of the negative aspects of cyberspace andcyberculture. First, it offers an examination of the impact of our use ofsocial media, and Facebook in particular, on our psyches, pointing out thatusers of social media can be thought of as audiences. These audiencesand information about them can be sold to marketers and advertisers.Next, it offers a case study of a widespread social problem in Japan, morethan a million media-obsessed Japanese young men (and some youngwomen), the hikikomori, who shut themselves off from society for monthsor years at a time. This is followed by a discussion of the impact of mobiles,primarily smartphones, on American adolescents, some of whom textone hundred messages a day to their friends. The effects of the enormousamount of face-time young people spend with screens—around tenhours per day--are also considered. Finally, there is an examination of theimpact that Amazon.com, the leading e-commerce Internet site, has hadon American shopping practices and American culture and society. Thearticle concludes with a discussion of the work of Hubert Dreyfus aboutsome negative effects of the Internet and, by implication, cyberspace andcyberculture, which, he argues, drain life of meaning

SIX MARKETING TYPOLOGIES IN SEARCH OF A CUSTOMER (WITH APOLOGIES TO LUIGI PIRANDELLO)

Studying consumer lifestyles and ethnocentrism is a unique way of finding out buyer behavior and market segmentation. This chapter discusses two of the most popular marketing typologies, The Values, Attitudes and Lifestyles (VALS) 1 and 2 typology and the Claritas typology. The methodological issues include measure equivalence and sample equivalence of the segmentation (Lim, Yoo, & Park, 2018; Maciejewski, Mokrysz, & Wróblewski, 2019) basis, segmentation methods employed, and whether national sample sizes should be proportional to population sizes (Steenkamp & Ter Hofstede, 2002). It argues that these typologies have certain deficiencies and suggests a different typology, the Grid-Group typology which suggests there are four lifestyles (consumer cultures) that are all in opposition to one another, but which shape consumer preferences for members of each culture

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies