A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full

<p>Abstract</p> <p>Background</p> <p>We assessed the prevalence, and potential impact of, trials of pharmacological agents for acute stroke that were completed but not published in full. Failure to publish trial data is to be deprecated as it sets aside the altruism of participants' consent to be exposed to the risks of experimental interventions, potentially biases the assessment of the effects of therapies, and may lead to premature discontinuation of research into promising treatments.</p> <p>Methods</p> <p>We searched the Cochrane Stroke Group's Specialised Register of Trials in June 2008 for completed trials of pharmacological interventions for acute ischaemic stroke, and searched MEDLINE and EMBASE (January 2007 - March 2009) for references to recent full publications. We assessed trial completion status from trial reports, online trials registers and correspondence with experts.</p> <p>Results</p> <p>We identified 940 trials. Of these, 125 (19.6%, 95% confidence interval 16.5-22.6) were completed but not published in full by the point prevalence date. They included 16,058 participants (16 trials had over 300 participants each) and tested 89 different interventions. Twenty-two trials with a total of 4,251 participants reported the number of deaths. In these trials, 636/4251 (15.0%) died.</p> <p>Conclusions</p> <p>Our data suggest that, at the point prevalence date, a substantial body of evidence that was of relevance both to clinical practice in acute stroke and future research in the field was not published in full. Over 16,000 patients had given informed consent and were exposed to the risks of therapy. Responsibility for non-publication lies with investigators, but pharmaceutical companies, research ethics committees, journals and governments can all encourage the timely publication of trial data.</p

Idoso vítima de queimaduras: identificação do diagnóstico e proposta de intervenção de enfermagem Anciano con quemadura: identificación del diagnóstico y propuesta de intervención de enfermería Aged victim of burns: identification of diagnosis and proposal of nursing interventions

Estudo de caso que objetivou identificar os Diagnósticos de Enfermagem (DE) conforme taxonomia II da Nursing American Nursing Association (NANDA), em idoso vítima de queimaduras de 2° e 3° graus e elaborar as intervenções de Enfermagem. Foram identificados oito DE, sendo cinco com presença de características definidoras e fatores relacionados (atuais) e três de risco. Elaborou-se propostas de intervenção iniciando pelas necessidades relacionadas aos sistemas vitais, fisiológicos, base da hierarquia das necessidades humanas básicas. Ao final, observou-se a importância da aplicabilidade do processo de enfermagem na implementação do cuidado e a necessidade do mesmo no exercício do fazer cotidiano.<br>Estúdio de caso cuyo objetivo fué identificar los Diagnósticos de Enfermería (DE) según la taxonomia II de North Ameircan Nursing Diagnosis Association (NANDA), de lo anciano com quemadura de 2° e 3° grado. Fueron identificados ocho DE de los más, cinco con presencia de características definidoras y factores relacionados (reales), y três de riesgos. Posteriomente, fueron elaboradas las porpuestas de intervención comenzado por la aplicabilidad del proceso de enfermería em la implementación del cuidado y la necessidad del mismo en el ejercício del hacer diário de enfermería.<br>This case study aimed at identifying the Nursing Diagnosis (ND) in agreement with the taxonomy II of the North-American Nursing Diagnosis Association (NANDA) of a patient victim of burning of 2nd e 3th degrees and to elaborate the nursing interventions. Eight ND were identified being five with the presence of defining characteristics and related factors (real), and three of risk. Intervention proposal was elaborated starting by the needs related to the vital and physiologic signs, the base of human basic needs hierarchy. Finally, it was observed the relevance of nursing process applicability in the implementation of care and its need in daily nursinga activitiies