418 research outputs found
About the Functional Form of the Parisi Overlap Distribution for the Three-Dimensional Edwards-Anderson Ising Spin Glass
Recently, it has been conjectured that the statistics of extremes is of
relevance for a large class of correlated system. For certain probability
densities this predicts the characteristic large fall-off behavior
, . Using a multicanonical Monte Carlo technique,
we have calculated the Parisi overlap distribution for the
three-dimensional Edward-Anderson Ising spin glass at and below the critical
temperature, even where is exponentially small. We find that a
probability distribution related to extreme order statistics gives an excellent
description of over about 80 orders of magnitude.Comment: 4 pages RevTex, 3 figure
Determining the density of states for classical statistical models: A random walk algorithm to produce a flat histogram
We describe an efficient Monte Carlo algorithm using a random walk in energy
space to obtain a very accurate estimate of the density of states for classical
statistical models. The density of states is modified at each step when the
energy level is visited to produce a flat histogram. By carefully controlling
the modification factor, we allow the density of states to converge to the true
value very quickly, even for large systems. This algorithm is especially useful
for complex systems with a rough landscape since all possible energy levels are
visited with the same probability. In this paper, we apply our algorithm to
both 1st and 2nd order phase transitions to demonstrate its efficiency and
accuracy. We obtained direct simulational estimates for the density of states
for two-dimensional ten-state Potts models on lattices up to
and Ising models on lattices up to . Applying this approach to
a 3D spin glass model we estimate the internal energy and entropy at
zero temperature; and, using a two-dimensional random walk in energy and
order-parameter space, we obtain the (rough) canonical distribution and energy
landscape in order-parameter space. Preliminary data suggest that the glass
transition temperature is about 1.2 and that better estimates can be obtained
with more extensive application of the method.Comment: 22 pages (figures included
Safety and efficacy of exercise training in adults with Pompe disease: Evalution of endurance, muscle strength and core stability before and after a 12 week training program
Background: Pompe disease is a proximal myopathy. We investigated whether exercise training is a safe and useful adjuvant therapy for adult Pompe patients, receiving enzyme replacement therapy. Methods: Training comprised 36 sessions of standardized aerobic, resistance and core stability exercises over 12 weeks. Before and after, the primary outcome measures safety, endurance (aerobic exercise capacity and distance walked on the 6 min walk test) and muscle strength, and secondary outcome measures core stability, muscle function and body composition, were evaluated. Results: Of 25 patients enrolled, 23 successfully completed the training. Improvements in endurance were shown by increases in maximum workload capacity (110 W before to 122 W after training, [95 % CI of the difference 6 · 0 to 19 · 7]), maximal oxygen uptake capacity (69 · 4 % and 75 · 9 % of normal, [2 · 5 to 10 · 4]), and maximum walking distance (6 min walk test: 492 meters and 508, [-4 · 4 to 27 · 7]). There were increases in muscle strength of the hip flexors (156 · 4 N to 180 · 7 N [1 · 6 to 13 · 6) and shoulder abductors (143 · 1 N to 150 · 7 N [13 · 2 to 35 · 2]). As an important finding in secondary outcome measures the number of patients who were able to perform the core stability exercises rose, as did the core stability balancing time (p < 0.05, for all four exercises). Functional tests showed small reductions in the time needed to climb four steps (2 · 4 sec to 2 · 1, [- 0 · 54 to -0 · 04 ]) and rise to standing position (5 · 8 sec to 4 · 8, [-2 · 0 to 0 · 0]), while time to run, the quick motor function test results and body composition remained unchanged. Conclusions: Our study shows that a combination of aerobic, strength and core stability exercises is feasible, safe and beneficial to adults with Pompe disease
Study protocol of the exercise study:Unraveling limitations for physical activity in children with chronic diseases in order to target them with tailored interventions—A randomized cross over trial
Higher cortisol levels may proceed a manic episode and are related to disease severity in patients with bipolar disorder
FSW – Publicaties zonder aanstelling Universiteit Leide
Deceleration and trapping of heavy diatomic molecules using a ring-decelerator
We present an analysis of the deceleration and trapping of heavy diatomic
molecules in low-field seeking states by a moving electric potential. This
moving potential is created by a 'ring-decelerator', which consists of a series
of ring-shaped electrodes to which oscillating high voltages are applied.
Particle trajectory simulations have been used to analyze the deceleration and
trapping efficiency for a group of molecules that is of special interest for
precision measurements of fundamental discrete symmetries. For the typical case
of the SrF molecule in the (N,M) = (2, 0) state, the ring-decelerator is shown
to outperform traditional and alternate-gradient Stark decelerators by at least
an order of magnitude. If further cooled by a stage of laser cooling, the
decelerated molecules allow for a sensitivity gain in a parity violation
measurement, compared to a cryogenic molecular beam experiment, of almost two
orders of magnitude
The transfer matrix in four-dimensional CDT
The Causal Dynamical Triangulation model of quantum gravity (CDT) has a
transfer matrix, relating spatial geometries at adjacent (discrete lattice)
times. The transfer matrix uniquely determines the theory. We show that the
measurements of the scale factor of the (CDT) universe are well described by an
effective transfer matrix where the matrix elements are labeled only by the
scale factor. Using computer simulations we determine the effective transfer
matrix elements and show how they relate to an effective minisuperspace action
at all scales.Comment: 32 pages, 19 figure
4f-spin dynamics in La(2-x-y)Sr(x)Nd(y)CuO(4)
We have performed inelastic magnetic neutron scattering experiments on
La(2-x-y)Sr(x)Nd(y)CuO(4) in order to study the Nd 4f-spin dynamics at low
energies. In all samples we find at high temperatures a quasielastic line
(Lorentzian) with a line width which decreases on lowering the temperature. The
temperature dependence of the quasielastic line width Gamma/2(T) can be
explained with an Orbach-process, i.e. a relaxation via the coupling between
crystal field excitations and phonons. At low temperatures the Nd-4f magnetic
response S(Q,omega) correlates with the electronic properties of the
CuO(2)-layers. In the insulator La(2-y)Nd(y)CuO(4) the quasielastic line
vanishes below 80 K and an inelastic excitation occurs. This directly indicates
the splitting of the Nd3+ ground state Kramers doublet due to the static
antiferromagnetic order of the Cu moments. In La(1.7-x)Sr(x)Nd(0.3)CuO(4) with
x = 0.12, 0.15 and La(1.4-x)Sr(x)Nd(0.6)CuO(4) with x = 0.1, 0.12, 0.15, 0.18
superconductivity is strongly suppressed. In these compounds we observe a
temperature independent broad quasielastic line of Gaussian shape below T about
30 K. This suggests a distribution of various internal fields on different Nd
sites and is interpreted in the frame of the stripe model. In
La(1.8-y)Sr(0.2)Nd(y)CuO(4) (y = 0.3, 0.6) such a quasielastic broadening is
not observed even at lowest temperature.Comment: 8 pages, 10 figures included, to appear in Phys. Rev.
Chemical proteomics reveals antibiotic targets of oxadiazolones in MRSA
Molecular PhysiologyBio-organic Synthesi
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