Association of polymorphisms of cardiovascular system genes with idiopathic recurrent pregnancy loss of Kazakh populations

The interrelation of polymorphic variants of coagulationand cardiovascular system geneswas studied: MTHFR (C677T, A1298C), MTR(А2756G), MTRR (A66G), F5 (А506G), F2 (G20210А),FGB (G455A), ITGB3 (Leu33Pro), PLANH1 (5G/4G); GPIa(C807T), AGTR1 (A1166C), ACE (I/D), eNOS (Glu298Asp)with development of idiopathic form of recurrent pregnancyloss (iRPL) in ethnically homogeneous populationof the Kazakhs. The results of independent replicativeTaqMan genotyping of 302 patients with iRPL and 300women with normal reproduction did not reveal an associationof studied polymorphisms with the developmentof iRPL in the Kazakh population

La expectativa de jubilación como un estrés psicológico que afecta la edad biológica en las persona de la Federación de Rusa

The method of age-related samples is used. Biological age is estimated using a formula including indicators of metabolism, cardiovascular, respiratory, equilibrium systems, and psychological health questionnaire data. The biological age, proper biological age, and relative aging index have been researched. Examinees were adults of 26 - 88 years old, divided into 9 age groups. We’ve founded two types of psychological stress affecting a person’s biological age: stress caused by the expectation of retirement and stress on the retirement. Upon the results of the study, it’s stated that in Russia the biological age of a person is associated with a calendar inverted U-shaped dependence. The peak of relative aging happens on the pre-retirement and post-retirement ages. In women, biological aging begins to intensify in the period of 51-60 years, in men in 46-50 years, in women it stops in the period of 66-70 years, and in men only after 71 years. The maximum of biological consenescence in women occurs immediately after retirement (56-60 years), and in men at the age of the expectation of retirement (56-60 years). Based on the achieved data, it can be concluded that psychological stress caused by the expectation of retirement exists, it’s more severe in men than in women.Se utiliza el método de muestras relacionadas con la edad. La edad biológica se estima utilizando una fórmula que incluye indicadores de metabolismo, cardiovasculares, respiratorios, sistemas de equilibrio y datos de cuestionarios de salud psicológica. Se ha investigado la edad biológica, la edad biológica adecuada y el índice de envejecimiento relativo. Los examinados eran adultos de 26 a 88 años, divididos en 9 grupos de edad. Hemos fundado dos tipos de estrés psicológico que afectan la edad biológica de una persona: el estrés causado por la expectativa de jubilación y el estrés en la jubilación. Sobre los resultados del estudio, se afirma que en Rusia la edad biológica de una persona está asociada con una dependencia de calendario en forma de U invertida. El pico del envejecimiento relativo ocurre en las edades previas y posteriores a la jubilación. En las mujeres, el envejecimiento biológico comienza a intensificarse en el período de 51-60 años, en los hombres en 46-50 años, en las mujeres se detiene en el período de 66-70 años, y en los hombres solo después de 71 años. El máximo de consenso biológico en las mujeres ocurre inmediatamente después de la jubilación (56-60 años) y en los hombres a la edad de la expectativa de jubilación (56-60 años). Con base en los datos obtenidos, se puede concluir que el estrés psicológico causado por la expectativa de jubilación existe, es más severo en los hombres que en las mujeres

Effect of mechanical activation on the composition if mineral components in humic acids isolated from carbons

It is shown that the mechanical activation of oxidized and brown coals is accompanied by an increase in the yield of humic acids and in their content of functional groups. It was demonstrated by atomic-emission spectroscopy that, under a high-intensity mechanical treatment, mineral elements are redistributed in the coal substance and incorporated into the structure of humic acids

Modeling personality structure using semantic relationships: Is the HEXACO Honesty-Humility a distinct trait?

Background: Although the Big Five model (BFM) of personality has been the dominant paradigm in personality research since the mid-1990s, it has recently been challenged by the HEXACO model, which contains an additional factor called Honesty-Humility. Since both these models of personality were developed using the same factor analytic techniques, there has been an ongoing but inconclusive debate about the relative merits of these competing models. Objective: This paper assesses the robustness of the Honesty-Humility trait using a technique based on the semantic relationships between personality trait adjectives. Design: Trait marker adjectives for the HEXACO Honesty-Humility and BFM Agreeableness and Neuroticism personality domains in the English language are translated into, and back-translated from, six Asian languages to generate lists of closely related trait terms known as schedonyms. The numbers of schedonyms found within and across the three personality domains are then compared, to determine whether the HEXACO Honesty-Humility factor is semantically distinct from the BFM traits of Agreeableness and Neuroticism. Results: Our fndings indicate that the Honesty-Humility trait domain is semantically distinct from the BFM traits of Agreeableness and Neuroticism, and therefore that there is at least one more personality trait beyond the BFM. The implications of these fndings, and the potential applications of this semantically-based technique for establishing the universal structure of the human personality, are briefy discussed. Conclusion: Our semantic analysis provides clear evidence that there is an Honesty-Humility trait domain in addition to the Agreeableness and Neuroticism traits, and therefore that HEXACO provides a better description of human personality than the BFM

A study of the association between identity, life engagement and well-being among young Asian adults

The eudaemonic tradition asserts that life engagement, that is the pursuit of a meaningful way of living, is an important element of well-being. Self-identity theory posits that individuals’ identities significantly contribute to their sense of meaning and belonging, which in turn boost well-being. The present study aimed to establish the extent to which self-identities are predictors of wellbeing and whether they are subsumed within the life engagement construct. An opportunity sample of Singaporeans (n = 269) aged 18–35 (M = 23.88, SD = 4.52) completed the Aspects of Identity Questionnaire, Warwick-Edinburgh Mental Well-Being Scale and Life Engagement Test. Correlational analysis showed that personal, social, relational and collective identities were significantly associated with life engagement and well-being. However, multiple regressions demonstrated that life-engagement subsumed collective and relational identity almost completely, and also accounted for a significant amount of the variance in personal and social identities in the prediction of well-being, broadly supporting the eudaemonic model. It was shown that social and personal identities were predictors of well-being beyond life engagement, possibly because these identities satisfy some of psychological needs that promote various benefits that are independent of life engagement, yet still important for wellbeing. It is suggested that these differences in the salience of identity types to well-being may be indicative of changes in the sense of identity among young Singaporeans that have arisen as a result of social policy or possibly changes in the ways of identity expression in the Internet. The implications of the findings are discussed and recommendations made for future research

The effects of music induction on mood and affect in an Asian context

A sample of Asian participants was assessed using the Brunel Mood Scale and the Positive & Negative Affect Scale before and after music mood induction procedures to which each participant was randomly assigned. A series of mixed analyses of variance with the type of music (happy/positive vs. sad/negative) as the between-subject factor and pre–post music exposure as the within-subject factor revealed that the sad music induction attenuated the positive moods Vigor and Happiness, as well as the negative moods Anger, Tension, Fatigue, and Confusion but had no significant impact on Depression or Calmness, casting doubt on the robustness of Thayer’s circumplex model of mood formation. The happy music induction increased Vigor and decreased Fatigue and Confusion, suggesting that positive music has the potential to lift energy levels. The happy music induction led to increases in Positive Affect only, whereas the sad music condition attenuated both Positive Affect and Negative affect, casting doubt on Watson and Tellegen’s contention that the Affect systems are independent and suggesting that the bipolarity hypothesis may not provide a comprehensive explanation of mood formation. The mechanisms by which music may impact mood and potential differences in the expression of affect between Asian and Western participants are discussed

Ethnic characteristics of bone remodeling in female patients with type 2 diabetes mellitus

Background: Structural and metabolic disorders of bone tissue in women with T2DM have no clinical manifestations, but they are accompanied by the risk of fractures.Aim: To study the parameters of bone metabolism, BMD and microarchitectonics in female patients with T2DM in the Buryat population.Materials and methods: The observational single-center one-stage controlled study included 73 women with T2DM, which were divided into 2 groups depending on the functional state of the ovaries (reproductive and postmenopausal periods). In each group, subgroups of the Buryat and Russian populations were identified. The first group included 34 patients with T2DM of the reproductive period: 16 from the Buryat population and 18 from the Russian population. The second group consisted of 39 postmenopausal patients with T2DM: 17 from the Buryat population and 22 from the Russian population. The study of BMD in the lumbar spine (L1-L4), femoral neck (Neck), in the proximal femur (Total hip), trabecular bone score (TBS), serum osteocalcin (OC), N-terminal propeptide type 1 procollagen was carried out (P1NP), vitamin D 25 (OH), blood plasma type I collagen C-terminal telopeptide (β-Cross laps) and ionized calcium (iCa).Results: In female patients with T2DM of the reproductive age of the Buryat population, an increase in both markers of osteosynthesis P1NP (p=0.035), OC (p=0.047), and bone resorption β-Cross laps (p=0.040) was found relative to the similar group of the Russian population. In women with T2DM in the postmenopausal period of the Buryat population, there was also an increase in P1NP (p = 0.016), OC (p = 0.048), β-Cross laps (p = 0.020) compared with the group of postmenopausal women in the Russian population. Structural disorders, characterized by a decrease in TBS, were detected only in the postmenopausal period in female patients of the Buryat population compared to women in the Russian population (p = 0.029).Comparative analysis among women with T2DM of the Buryat population, depending on the functional state of the ovaries, showed that activation of bone remodeling with an increase in P1NP (p = 0.019), OC (p = 0.004) and β-Cross laps (p = 0.004) is characteristic of postmenopausal women accompanied by a decrease in BMD Neck (p = 0.006), BMD Total hip (p = 0.003), BMD L1-L4 (p = 0.049) and TBS (p = 0.020) relative to female patients with T2DM in the reproductive period.Conclusion: In women with T2DM in the Buryat population, both in the reproductive and postmenopausal periods, an increase in bone remodeling markers and BMD stability was found when compared with the corresponding groups of patients in the Russian population. The postmenopausal period was characterized by an additional decrease in TBS in patients with T2DM in the Buryat population relative to women in the Russian population

Experience in implementing a program for basic life support and available automated defibrillation in a cancer center

Unified approaches to ensuring the chain of survival can improve the patient’s prognosis both in out-of-hospital and in-hospital cardiac arrest.Aim. To discuss practical issues of introducing a program for the availability of automated external defibrillation in a cancer center.Material and methods. For four years, our healthcare facility has been implementing a training program for basic and advanced life support according to the European Resuscitation Council standards, combined with the creation and development of an infrastructure for the availability of automatic defibrillation. A roadmap and infrastructure were developed for the project implementation.Results. In 2018-2022, 229 employees (114 doctors, 85 nurses and 30 nonmedical workers) were trained under the basic life support program. Fifteen defibrillators were placed in various units. During the specified period, first aid in case of sudden cardiac arrest using an automated external defibrillator before the resuscitation team arrival was independently provided by doctors and nurses of departments three times. To implement training in the continuous education system, the curriculum has passed the examination and accreditation in the edu. rosminzdrav system.Conclusion. The development and implementation of such initiatives requires significant organizational and methodological work, including continuous education system. However, in our opinion, this is an extremely useful tool for improving the safety and quality of medical care

The MPIfR-MeerKAT Galactic Plane Survey II. The eccentric double neutron star system PSR J1208-5936 and a neutron star merger rate update

The MMGPS-L is the most sensitive pulsar survey in the Southern Hemisphere. We present a follow-up study of one of these new discoveries, PSR J1208-5936, a 28.71-ms recycled pulsar in a double neutron star system with an orbital period of Pb=0.632 days and an eccentricity of e=0.348. Through timing of almost one year of observations, we detected the relativistic advance of periastron (0.918(1) deg/yr), resulting in a total system mass of Mt=2.586(5) Mo. We also achieved low-significance constraints on the amplitude of the Einstein delay and Shapiro delay, in turn yielding constraints on the pulsar mass (Mp=1.26(+0.13/-0.25) Mo), the companion mass (Mc=1.32(+0.25/-0.13) Mo, and the inclination angle (i=57(2) degrees). This system is highly eccentric compared to other Galactic field double neutron stars with similar periods, possibly hinting at a larger-than-usual supernova kick during the formation of the second-born neutron star. The binary will merge within 7.2(2) Gyr due to the emission of gravitational waves. With the improved sensitivity of the MMGPS-L, we updated the Milky Way neutron star merger rate to be 25(+19/-9) Myr$^{-1}$ within 90% credible intervals, which is lower than previous studies based on known Galactic binaries owing to the lack of further detections despite the highly sensitive nature of the survey. This implies a local cosmic neutron star merger rate of 293(+222/-103} Gpc/yr, consistent with LIGO and Virgo O3 observations. With this, we predict the observation of 10(+8/-4) neutron star merger events during the LIGO-Virgo-KAGRA O4 run. We predict the uncertainties on the component masses and the inclination angle will be reduced to 5x10$^{-3}$ Mo and 0.4 degrees after two decades of timing, and that in at least a decade from now the detection of the shift in Pb and the sky proper motion will serve to make an independent constraint of the distance to the system