Pilot Study: Systemic response after lung SBRT analyzing immune Cells phenotyping

To investigate changes of immune-phenotyping values in patients treated with Stereotactic Body Radiation Therapy (SBRT) over the lung in order to evaluate the immune response after radiation therapy

Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis

An immunophenotyping analysis was performed in peripheral blood samples from seven patients with lung cancer unfit for surgery treated with stereotactic body radiotherapy (SBRT). The objective was to characterize the effect of SBRT on the host immune system. Four patients received 60 Gy (7.5 Gy x 8) and three 50 Gy (12.5 Gy x 4). Analyses were performed before SBRT, 72 h after SBRT, and at one, three, and six months after the end of SBRT. Of note, there was a specific increase of the immunoactive component of the immune system, with elevation of CD56(+high)CD16+ natural killer (NK) cells (0.95% at baseline to 1.38% at six months), and a decrease of the immunosuppressive component of the immune system, with decreases of CD4+CD25+Foxp3+CDA5RA- regulatory T cells (4.97% at baseline to 4.46% at six months), granulocytic myeloid-derived suppressor cells (G-MDSCs) (from 66.1% at baseline to 62.6% at six months) and monocytic (Mo-MDSCs) (8.2% at baseline to 6.2% at six months). These changes were already apparent at 72 h and persisted over six months. SBRT showed an effect on systemic immune cell populations, which is a relevant finding for supporting future combinations of SBRT with immunotherapy for treating lung cancer patients

Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30-0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients

Why should radiological oncology do translational research?

Radiological Oncology, like the rest of medical specialties, is beginning to provide can personalized therapies. The ongoing scientific advances enable a great degree of precision in diagnoses and therapies. To fight cancer, from a radiotherapy unit, requires up-to-date equipment, professionals with different specialties working in synchrony (doctors, physicists, biologists, etc.) and a lot of research. Some of the new therapeutic tendencies are immunotherapy, nanoparticles, gene therapy, biomarkers, artificial intelligence, etc. A new clinical paradigm in which new professional networks are inevitable is arising. The mission of translational research is to become a scientific engine in the clinical space

Enhancing radiotherapy effect in breast cancer with nanoparticles: A review

Amongst all efforts for improving oncological management outcomes, nanoparticles enhanced radiation for breast cancer patient's treatment is a novel approach that has grown interest for research in the last decade. Multiple preclinical data has been published, from all around the globe; however, clinical evidence is still insufficient for implementing the method in routine practice and in disease specific management. Gold nanoparticles (AuNP), which may be among the most studed materials, account for the majority of available data; however, some new materials have also been used in preclinical settings. Without any safety data available at the moment to support an active use, dosimetric in vitro and in vivo information seems to be consistent with a very promising and hopeful panorama for clinical applications. This review evaluates existing dosimetric data in breast cancer tissue, and a probable future impact in treatment choices and patient outcomes, as further investigation is required in a clinical setting

Anales de Edafología y Agrobiología Tomo 47 Número 5-6

l. Suelos-Física. Valores estimativos de la torrencialidad obtenidos por comparación de distintos métodos de valoración aplicados en la provincia de Valencia. Por V. Bordas Valls, V. Pons Marti y J. Sánchez Díaz.-- Química Metodología y valores estimados para definir el riesgo de degradación química de los suelos en la provincia de Valencia. Por V. Bordas y J. Sánchez.- Origen de materiales alofánicos en suelos volcánicos del campo de Calatrava (Ciudad Real). Por J. L. Martín de Vidales, J. Guijarro, M. A. Hoyos y J. Casas.-- Influencia de un ciclo agroforestal sobre la actividad ureásica en suelos cálcicos. Por S. González Carcedo, M. Pérez Mateos y E. Barriuso Benito.-- Génesis, Clasificación y Cartografía Suelos sobre sedimentos terciarios afectados por la terraza alta del Guadiana en Badajoz (España). Por A. García Navarro y L. Fernández Pozo.-- Génesis y clasificación de los suelos desarrollados sobre las anfibolitas de "Santiago - Ponte Ulla". Por B. M. Silva Hermo, E. García-Rodeja Gayoso, C. García Paz y F. Macías Vázquez.-- Factores ecológicos (Geología, vegetación y clima) de la comarca La Plana de Requena - Utiel (Valencia): I. Relaciones suelo-Material de origen. Por R. Boluda Hernández, V. Andréu Pérez, M. Moraleda Esteve y J. Sánchez Diaz.-- Factores ecológicos (Geología, vegetación y clima) de la comarca La Plana de Requena - Utiel (Valencia): II. Vegetación y clima. Por R. Boluda Hernández, V. Andréu Pérez, M. Moraleda Esteve y J. Sánchez Díaz. II. Biología Vegetal-Fisiología Efectos del ácido 2,4-Diclorofenoxiacético sobre el crecimiento, diferenciación y morfogénesis de un cultivo de callo de erysimum scoparium de un año de edad. Por J. F. Pérez Francés, F. Valdés, R. Martín y B. R. Rodríguez.-- Efecto del GA3 sobre el desarrollo del ápice del tallo de la cebada (Hordeum _ distichon L. cv. "Pallas"). Por M. Díaz-Miguel.-- Effect of elemental sulphur application to Brassica juncea coss. By L. L. Somani, l. J. Gulati, K. K. Vyas and P. C. Kanthalia.-- Efecto sobre la germinación de semillas del extracto hidrosoluble de hojas de especies mediterráneas: introducida: Eucalyptus globulus Labill y autóctonas: Quercus suber L., Quercus ilex L., Pinus pinea L., Cistus ladanifer L. y Halimium halimifolium Wk. Por M. T. Dominguez, E. G. Esparcia y F. Penalva.-- Agrobiologfa Calibration of critica! limits of various soil potassium parameters for wheat crop in Torri - psamment soils of western ghat (India). By S. P. Mazumdar and S. N. Sax Ena.--Factores ecológicos que determinan la distribución del olivo en la España peninsular. Por L. Ramirez-Pérez y B. Peco.-- III. Comunicaciones cortas. Relación suelo - agua en las formaciones de Raña del centro - oeste de España. Por R. Espejo Serrano, y J. Pérez Arias .-- Consideraciones sobre el estado actual y perspectivas en ecología del suelo. Por A. García Álvarez y J. J. lbáñez.-- IV. Trabajo recapitulativo. Origen, situación y características de las variedades de albaricoquero de Murcia. Por L. Eggea, T. Berenguer, J. Egea y J. E. García. NotasPeer reviewe