Information criteria determine the number of active sources

With the neuroelectromagnetic inverse problem, the optimal choice of the number of sources is a difficult problem, especially in the presence of correlated noise. In this paper we present a number of information criteria that help to solve this problem. They are based on the probability density function of the measurements or their eigenvalues. Make use of the Akaike or MDL (minimum description length) correction term and all employ some sort of noise information. By extensive simulations we investigated the conditions under which these criteria yield reliable estimations. We were able to quantify two major factors of influence: (1) the precision of the noise information and (2) the signal-to-noise ratio (SNR). Here defined as the ratio of the smallest signal eigenvalues and the average of the noise eigenvalues. Furthermore, we found that the Akaike correction term tends to overestimate, due to its greater sensibility to the precision of the noise informatio

Organizing knowledge sharing in networks: The theory

Introduction : over the past decade knowledge bas become a central concept in the field of organization studies. Knowledge helps companies to outperform competitors (Winter 1987). Knowledge can be compared with an accurate map. Having a map of the territory in which we want to travel gives us the coordinates of the places we want to go to and routes to get there. The map enables efficient travelling and avoid moving around by trial and error. Thus knowledge about technology, customers competitors and ways of organizing helps organizations to act efficiently and effectively

The fibres that hold an innovation network: An analysis of knowledge sharing in the Glare network

No abstract

Interactions for a collection of spin-two fields intermediated by a massless p-form

Under the general hypotheses of locality, smoothness of interactions in the coupling constant, Poincare invariance, Lorentz covariance, and preservation of the number of derivatives on each field, we investigate the cross-couplings of one or several spin-two fields to a massless p-form. Two complementary cases arise. The first case is related to the standard interactions from General Relativity, but the second case describes a new, special type of couplings in D=p+2 spacetime dimensions, which break the PT-invariance. Nevertheless, no consistent, indirect cross-interactions among different gravitons with a positively defined metric in internal space can be constructed.Comment: LaTeX; the content of v2 has been changed, some former results have been changed, new material has been added; accepted for publication in Nuclear Physics

Human Milk Oligosaccharide 2′-Fucosyllactose Modulates Local Viral Immune Defense by Supporting the Regulatory Functions of Intestinal Epithelial and Immune Cells

Human milk contains bioactive components that provide protection against viral infections in early life. In particular, intestinal epithelial cells (IEC) have key regulatory roles in the prevention of enteric viral infections. Here we established an in vitro model to study the modulation of host responses against enteric viruses mimicked by poly I:C (pIC). The effects of 2′-fucosyllactose (2′FL), abundantly present in human milk, were studied on IEC and/or innate immune cells, and the subsequent functional response of the adaptive immune cells. IEC were pre-incubated with 2′FL and stimulated with naked or Lyovec™-complexed pIC (LV-pIC). Additionally, monocyte-derived dendritic cells (moDC) alone or in co-culture with IEC were stimulated with LV-pIC. Then, conditioned-moDC were co-cultured with naïve CD4+ T helper (Th)-cells. IEC stimulation with naked or LV-pIC promoted pro-inflammatory IL-8, CCL20, GROα and CXCL10 cytokine secretion. However, only exposure to LV-pIC additionally induced IFNβ, IFNλ1 and CCL5 secretion. Pre-incubation with 2′FL further increased pIC induced CCL20 secretion and LV-pIC induced CXCL10 secretion. LV-pIC-exposed IEC/moDC and moDC cultures showed increased secretion of IL-8, GROα, IFNλ1 and CXCL10, and in the presence of 2′FL galectin-4 and -9 were increased. The LV-pIC-exposed moDC showed a more pronounced secretion of CCL20, CXCL10 and CCL5. The moDC from IEC/moDC cultures did not drive T-cell development in moDC/T-cell cultures, while moDC directly exposed to LV-pIC secreted Th1 driving IL-12p70 and promoted IFNγ secretion by Th-cells. Hereby, a novel intestinal model was established to study mucosal host-defense upon a viral trigger. IEC may support intestinal homeostasis, regulating local viral defense which may be modulated by 2′FL. These results provide insights regarding the protective capacity of human milk components in early life

Diffractive light quark jet production at hadron colliders in the two-gluon exchange model

Massless quark and antiquark jet production at large transverse momentum in the coherent diffractive processes at hadron colliders is calculated in the two-gluon exchange parametrization of the Pomeron model. We use the helicity amplitude method to calculate the cross section formula. We find that for the light quark jet production the diffractive process is related to the differential off-diagonal gluon distribution function in the proton. We estimate the production rate for this process at the Fermilab Tevatron by approximating the off-diagonal gluon distribution function by the usual diagonal gluon distribution in the proton. And we find that the cross sections for the diffractive light quark jet production and the charm quark jet production are in the same order of magnitude. We also use the helicity amplitude method to calculate the diffractive charm jet production at hadron colliders, by which we reproduce the leading logarithmic approximation result of this process we previously calculated.Comment: 15 pages, 4 PS figures, Revte

Epithelial-derived galectin-9 containing exosomes contribute to the immunomodulatory effects promoted by 2’-fucosyllactose and short-chain galacto- and long-chain fructo-oligosaccharides

Introduction: Early life exposure to non-digestible oligosaccharides (NDO) or microbial components is known to affect immune development. NDO in combination with a TLR9 agonist mimicking bacterial triggers (CpG) promoted the secretion of galectins through unknown pathways. We aimed to study the contribution of exosomes in epithelial galectin secretion and subsequent immunoregulation upon exposure to a mixture of NDO by inhibiting exosome biogenesis. Methods: Human intestinal epithelial cells (IEC) (FHs 74 Int or HT-29) were apically exposed to 2’-fucosyllactose (2’FL) and short-chain galacto- and long-chain fructo-oligosaccharides (GF), alone or with CpG. Basolaterally, non-activated or αCD3/CD28-activated peripheral blood mononuclear cells (PBMC) were added. After 24 h incubation, IEC were washed and incubated in fresh medium to analyze epithelial-derived galectin secretion. Additionally, before exposure to NDO and CpG, IEC were exposed to GW4869 to inhibit exosome biogenesis. After 24 h of incubation, IEC were washed and incubated for additional 24 h in the presence of GW4869, after which epithelial-derived galectin secretion was studied. Also, epithelial-derived exosomes were isolated to study the presence of galectins within the exosomes. Results: Compared to CpG alone, exposure to 2’FL/GF mixture and CpG, significantly enhanced Th1-type IFNγ, and regulatory IEC-derived galectin-9 secretion in the HT-29/PBMC model. Similarly, in the FHs 74 Int/PBMC co-culture, 2’FL/GF induced immunomodulatory effects in the absence of CpG. Interestingly, galectin-9 and -4 were present in CD63-expressing exosomes isolated from HT-29 supernatants after IEC/PBMC co-culture. Exposure to GW4869 suppressed 2’FL/GF and CpG induced epithelial-derived galectin-9 secretion, which subsequently prevented the rise in IL-10 and reduction in IL-13 secretion observed in the HT-29/PBMC co-culture model upon exposure to 2’FL/GF and CpG. Discussion: Exposure to 2’FL/GF and CpG or 2’FL/GF promoted Th1-type regulatory effects in HT-29/PBMC or FHs 74 Int/PBMC co-culture respectively, while Th2-type IL-13 was reduced in association with increased galectin-9 release. Galectin-9 and -4 were present in exosomes from HT-29 and the inhibition of exosome biogenesis inhibited epithelial-derived galectin secretion. This, also affected immunomodulatory effects in IEC/PBMC co-culture suggesting a key role of galectin expressing IEC-derived exosomes in the mucosal immune regulation induced by NDO

Measurement of main parameters of the \psi(2S) resonance

A high-precision determination of the main parameters of the \psi(2S) resonance has been performed with the KEDR detector at the VEPP-4M e^{+}e^{-} collider in three scans of the \psi(2S) -- \psi(3770) energy range. Fitting the energy dependence of the multihadron cross section in the vicinity of the \psi(2S) we obtained the mass value M = 3686.114 +- 0.007 +- 0.011 ^{+0.002}_{-0.012} MeV and the product of the electron partial width by the branching fraction into hadrons \Gamma_{ee}*B_{h} = 2.233 +- 0.015 +- 0.037 +- 0.020 keV. The third error quoted is an estimate of the model dependence of the result due to assumptions on the interference effects in the cross section of the single-photon e^{+}e^{-} annihilation to hadrons explicitly considered in this work. Implicitly, the same assumptions were employed to obtain the charmonium leptonic width and the absolute branching fractions in many experiments. Using the result presented and the world average values of the electron and hadron branching fractions, one obtains the electron partial width and the total width of the \psi(2S): \Gamma_{ee} =2.282 +- 0.015 +- 0.038 +- 0.021 keV, \Gamma = 296 +- 2 +- 8 +- 3 keV. These results are consistent with and more than two times more precise than any of the previous experiments