Black girls navigate the physical and emotional landscape of the neighbourhood: Normalized violence and strategic agency

This article considers how young Black women living in gang-affected neighbourhoods in an urban area in England, UK navigate their safety in public and private spaces, and how these spaces overlap and intersect. Drawing on a project with 18 participants aged 14–19, the research seeks to understand how the participants inhabit, navigate and strategize for their safety through their narratives of life and survival in an unsafe neighbourhood. Findings indicate that they experience sexual harassment in public spaces and gang-associated sexual and physical violence as common, accepted aspects of their everyday realities, from as young as 12. The narratives suggest that participants navigate complex friendship groups to protect each other and their families through tight codes of trust, secrecy, privacy and conflict-management strategies. This article seeks to bring attention to how young women utilize their agency to illuminate the coping strategies they draw on to navigate their physical environments. The article concludes with a discussion of the implications for interventions

Priprava i evaluacija mukoadhezivnih filmova glipizida

Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged time intervals. Polymeric films were designed with various compositions of hydroxypropyl cellulose and polyethylene glycol 400 (PEG 400). Properties of the mucoadhesive film such as tensile strength, percentage elongation, swelling index, moisture content, pH and viscosity of polymeric dispersion, film thickness, drug concentration, uniformity and mucoadhesion in a simulated gastric environment were evaluated. In addition, percentage drug retained in stomach mucosa was estimated using a simulated dynamic stomach system as a function of time. Increase in hydroxypropyl cellulose concentration resulted in a higher tensile strength and elongation at break, while increase in concentration of PEG 400 was reflected in a decrease of tensile strength and increase of elongation at break. Glipizide/hydroxypropyl cellulose/PEG 400 (2.5:1:0.5) (GF5) was found to be the optimal composition for a novel mucoadhesive stomach formulation that showed good peelability, relatively high swelling index, moderate tensile strength, and stayed on rat stomach mucosa up to 8 h. In vivo testing of the mucoadhesive films with glipizide demonstrated a potential hypoglycemic effect.Glipizid se pretežno apsorbira u proksimalnom dijelu gastrointestinalnog trakta. Cilj rada je priprava i evaluacija mukoadhezivnih filmova s kojima bi se produljilo zadržavanje lijeka u predjelu apsorpcije. Pripravljeni su mukoadhezivni filmovi glipizida koji se produljeno zadržavaju u želucu. Polimerni filmovi sadržavali su različite količine hidroksipropil celuloze i polietilen glikola 400 (PEG 400). Evaluirana su sljedeća svojstva mukoadhezivnih filmova: čvrstoća, postotak elongacije, indeks bubrenja, sadržaj vlage, pH i viskoznost polimerne disperzije, debljina filma, koncentracija lijeka, jednolikost i mukoadhezivnost u simuliranom želučanom soku. Na dinamičkom modelu želuca određivan je i postotak lijeka koji se zadržava u sluznici želuca u ovisnosti o vremenu. Povećanjem koncentracije hidroksipropil celuloze povećavaju se čvrstoća i elongacija, dok se povećanje koncentracije PEG 400 reflektira na smanjenje čvrstoće i povećanje elongacije kod loma. Omjer glipizid/hidroksipropil celuloza/PEG 400 (2,5:1:0,5) (GF5) bio je optimalan za pripravu mukoadhezivnih formulacija, s dobrom kalavošću, relativno visokim indeksom bubrenja, umjerenom čvrstoćom te zadržavanjem u sluznici želuca štakora do 8 h. U in vivo testiranjima mukoadhesivni filmovi s glipizidom pokazali su potencijalni hipoglikemijski učinak

Gallium in the detection and localization of tumours

The use of Gallium c:trate and gamma-imaging with a gamma camera as a diagnostic procedure for the detection and localization of malignant disease has been evaluated in 64 patients with malignant disease. From the results obtained it can be concluded that Gallium citrate can play an extremely useful diagnostic role as a tumour scanning agent. 'Best results are obtained in patients with sarcomata of any type and lymphomata. The procedure is less useful for the detection of carcinoma although diagnostically valuable information may be obtained with primary carcinoma of the maxillary antrum, breast and lung and in the case of metastatic carcinoma involving bone.S. Afr. Med. J., 45, 1351 (1971)