18 research outputs found
Super-Eddington accretion in the Q2237+0305 quasar?
The interband time lags between the flux variations of the Q2237+0305 quasar
have been determined from light curves in the Johnson-Cousins V, R, and I
spectral bands. The values of the time lags for filter pairs R-V, I-R, and I-V
are significantly higher than those predicted by the standard accretion disk
model by Shakura and Sunyaev. To explain the discrepancy, the idea of a
supercritical accretion regime in quasars considered in 1973 by Shakura and
Sunyaev is applied. This regime has been shown by them to cause an extended
scattering envelope around the accretion disk. The envelope efficiently
scatters and re-emits the radiation from the accretion disk and thus increases
the apparent disk size. We made use of analytical expressions for the envelope
radius and temperature derived by Shakura and Sunyaev in their analysis of
super-Eddington accretion and show that our results are consistent with the
existence of such an envelope. The corresponding parameters of the accretion
regime were calculated. They provide the radii of the envelope in the V, R, and
I spectral bands consistent with the inter-band time lags determined in our
work.Comment: 11 pages, 4 figure
ETHNIC PECULIARITIES OF SLEEP DISORDERS IN EASTERN SIBERIA
The purpose of this investigation was to study the ethnic peculiarities of sleep disorders in European and Mongoloid races living in Eastern Siberia. In this study we performed questioning of409 respondents of Europeans (Russian) 203 (49.63 %) and Mongoloid (Buryats) 206 (50.37 %) aged 20-60 years. Living in the Irkutsk region and the Buryat Republic. Gender structure: 270females (66.9 %) and 125 males (33.1 %). Standard questionnaire of Stanford Sleep Research Center (USA) included a complex of questions about problems of sleep and their subjective assessment: no problems; light problem, moderate problem, severe problem. PSG-monitoring applying system GRASSTELEFACTOR Twin PSG (Comet) with amplifier As 40 with integrated module for sleep SPM-1 (USA). It was revealed that "light" sleep problems note 25.1 % of native ethnic group respondents (Buryats) and 38.3 % of Russian respondents (p < 0.05). The moderate sleep disorders were characteristic of 8.7 % Buryats and 3.1 % Russian (p < 0.05), and the severe sleep disorders 5.3 % and 2.2 %, respectively (p < 0.05). Severe sleep disorders noted 7.2 % Buryat women versus 1.8 % in the group of Russian women (p < 0.05), among men the severe sleep disorders is significantly higher (23.8 % in the Buryats and Russian 14.6 %, p < 0.05). We identified correlation between body mass index (BMI) and obstructive sleep apnea (OSA) in males of Mongoloid race (with OSA BMI was 33.37 kg/cm2, without 24.86 kg/cm2, p < 0.05). According to the results of the PSG study in males of the both ethnic groups, a higher incidence of moderate and severe OSA in the Buryats (28.2 % and 20.1 %, respectively, p < 0.05). In general, these results confirm the presence of more severe sleep disorders in Mongoloids (including OSA), but certain anatomical features for the formation of OSA we have not found, that require further study
PREDICTING THE RISK OF PROTHROMBOTIC CHANGES IN ADOLESCENTS WITH ESSENTIAL HYPERTENSION
Today, the problem of early diagnosis of hematological changes predisposing to the development of thrombotic complications in patients with essential hypertension (EH) is an urgent problem that requires close attention not only of physicians, but also of pediatricians. The aim of the study was the development of prognostic criteria for risk of prothrombotic changes (PC) in adolescents with EH, timely preventive measures and prevention of thrombotic complications. Sixty adolescents with EH without PC and 37 adolescents with EH and PC were examined. We used the following methods: clinical anamnestic (including genealogy), functional and ultrasound, laboratory, mathematical and statistical. To create a mathematical model of forecasting, discriminant analysis was used, with the help of which from the 59 proposed predictors the algorithm selected 8 most informative features: the C777T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene, the A66G gene of the methionine synthase reductase gene, the daily diastolic blood pressure level, the level of the nocturnal systolic arterial pressure-time index of hypertension, systolic blood pressure during the day, weighed down by thrombotic genealogically history, early onset of thrombosis, burdened thrombotic genealogical history. Our method for predicting the risk of developing PC allows to place adolescents with EH having an increased risk of developing these coagulation shifts in a separate group, to identify thrombogenic risk in adolescence and, if necessary, to initiate preventive measures in time to reduce the incidence of thrombotic complications of EH and mortality of patients
Voluntary attention in the ontogenesis of adolescents with essential hypertension
The purpose of the research was to study the features of voluntary attention ontogenesis in adolescents with essential hypertension (EH) in age-gender aspects. Materials and methods. We examined 98 adolescents with EH aged 10-18 years (59 males and 39 females). EH was diagnosed with 24-h ambulatory blood pressure (BP) monitoring using monitor Oscar 2 for OXFORD Medilog Prima. Ninety-seven healthy age- and gender-matched individuals were controls. All participants were divided into 3 age groups (10-12 years, 13-15 years and 16-18 years old). All children underwent a neuropsychological examination with the use of standard tests. All the differences were considered significant at p < 0.05. Results. There were no statistically significant differences in voluntary attention parameters in adolescents 10-12 years old in both the main and the control group. However, hypertensive adolescents aged 13-15 years had significantly decreased voluntary attention level in comparison with age-matched individuals in controls. Adolescents in this group spent much more time on testing and admitted a significant number of errors. In the group of older adolescents (16-18 years), the differences between the main and the control group continued to increase. Hypertensive girls have a tendency with better voluntary attention parameters than hypertensive boys. When comparing the tests results between the age groups of hypertensive patients, a tendency to their deterioration as the disease progresses is noted. Conclusion. The results of this study indicate the formation of a rigid pathological functional brain system in the ontogenesis in hypertensive adolescents with the development of brain structures decompensation and voluntary attention impairment
Π‘ΠΈΠ½Π΄ΡΠΎΠΌ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π°ΠΏΠ½ΠΎΡ ΡΠ½Π°: Π½ΠΎΡΠ½Π°Ρ ΠΈΠ½ΡΠ΅ΡΠΌΠΈΡΡΠΈΡΡΡΡΠ°Ρ Π³ΠΈΠΏΠΎΠΊΡΠΈΡ ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅Π»ΠΎΠΌΠ΅ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
Obstructive sleep apnea syndrome (OSAS) is a common pathology of the respiratory system characterized by upper airway blockage during sleep. The blockage is caused by intermittent throat collapse and thereby no lung ventilation with preserved respiratory efforts. Earlier we demonstrated that telomeres at the end of chromosomes shorten during intermittent nocturnal hypoxia and sleep fragmentation in OSA patients; the elimination of OSA triggers contributed to an increase in relative telomere length (RTL). The search for the relationship between telomeres and the telomerase complex activity with the sleep stages, as well as indicators of blood oxygen saturation in OSA, seems relevant. Aim. To evaluate the activity of the telomerase complex main components and to determine its relationship with the sleep phases and the level of desaturation in patients with OSA. Methods. The main group included 32 men (age 51.2 Β± 3.1 years) with complaints of snoring, respiratory arrest during sleep, and increased daytime sleep. The control group consisted of 26 matched volunteers without clinical manifestations of OSA. Patients of both groups did not have any exacerbations of their chronic conditions at baseline. The study included questionnaires, polysomnography monitoring, analysis of the RLT by PCR, ELISA to determine activity of the telomerase complex components, and statistical analysis. Results. Differences were revealed in the functioning of telomeres and the TERT, TEP1. A positive relationship between the oxygen blood saturation, telomere length and TER1 activity was found in OSA patients. Conclusion. We have identified the decrease in RTL and the telomerase complex activity and proved their positive relationship with the oxygen saturation during intermittent nocturnal hypoxia in OSA patients.Π‘ΠΈΠ½Π΄ΡΠΎΠΌ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π°ΠΏΠ½ΠΎΡ ΡΠ½Π° (Π‘ΠΠΠ‘) ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΏΠΎΠ²ΡΠΎΡΡΡΡΠΈΠΌΠΈΡΡ ΡΠΏΠΈΠ·ΠΎΠ΄Π°ΠΌΠΈ ΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ Π΄ΡΡ
Π°Π½ΠΈΡ Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΡΠ½Π° Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΏΠ°Π΄Π΅Π½ΠΈΡ Π²Π΅ΡΡ
Π½ΠΈΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ Π½Π° ΡΡΠΎΠ²Π½Π΅ Π³Π»ΠΎΡΠΊΠΈ ΠΈ ΠΏΡΠ΅ΠΊΡΠ°ΡΠ΅Π½ΠΈΠ΅ΠΌ Π»Π΅Π³ΠΎΡΠ½ΠΎΠΉ Π²Π΅Π½ΡΠΈΠ»ΡΡΠΈΠΈ ΠΏΡΠΈ ΡΠΎΡ
ΡΠ°Π½ΡΡΡΠΈΡ
ΡΡ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΠΈΠ»ΠΈΡΡ
. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ ΡΠ°ΠΊΡ ΡΠΊΠΎΡΠΎΡΠ΅Π½ΠΈΡ Π² ΡΠ΅Π»ΠΎΠΌΠ΅ΡΠ°Ρ
ΠΊΠΎΠ½ΡΠ΅Π²ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌ ΠΏΡΠΈ ΠΈΠ½ΡΠ΅ΡΠΌΠΈΡΡΠΈΡΡΡΡΠ΅ΠΉ Π½ΠΎΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ ΠΈ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΡΠ½Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘ΠΠΠ‘, ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠΈΠ³Π³Π΅ΡΠΎΠ² Π‘ΠΠΠ‘ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π»ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π»ΠΈΠ½Ρ ΡΠ΅Π»ΠΎΠΌΠ΅Ρ. ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠΈΡΠΊ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΡΠ΅Π»ΠΎΠΌΠ΅Ρ ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ΅Π»ΠΎΠΌΠ΅ΡΠ°Π·Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° (Π’Π) ΡΠΎ ΡΡΡΡΠΊΡΡΡΠ½ΡΠΌΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ ΡΠ½Π°, ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΊΡΠΎΠ²ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΈ Π‘ΠΠΠ‘. Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»Π°ΡΡ ΠΎΡΠ΅Π½ΠΊΠ° Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π’Π ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π΅Π³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΡΠΎ ΡΡΡΡΠΊΡΡΡΠ½ΡΠΌΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌΠΈ ΡΠ½Π° ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ Π΄Π΅ΡΠ°ΡΡΡΠ°ΡΠΈΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘ΠΠΠ‘. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠ½ΠΎΠ²Π½ΡΡ (1-Ρ) Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ (n = 32: 100 % β ΠΌΡΠΆΡΠΈΠ½Ρ; ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ β 51,2 Β± 3,1 Π³ΠΎΠ΄Π°) Ρ ΠΆΠ°Π»ΠΎΠ±Π°ΠΌΠΈ Π½Π° Ρ
ΡΠ°ΠΏ, ΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ Π΄ΡΡ
Π°Π½ΠΈΡ Π²ΠΎ Π²ΡΠ΅ΠΌΡ ΡΠ½Π°, ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΡ Π΄Π½Π΅Π²Π½ΡΡ ΡΠΎΠ½Π»ΠΈΠ²ΠΎΡΡΡ. ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ (2-Ρ) ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΡΡ (n = 26) Π±Π΅Π· ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ Π‘ΠΠΠ‘, ΠΏΠΎΠ΄ΠΎΠ±ΡΠ°Π½Π½ΡΠ΅ ΠΏΠΎ ΡΠΈΠΏΡ Β«ΠΊΠΎΠΏΠΈΡ-ΠΏΠ°ΡΠ°Β». ΠΠ±ΠΎΡΡΡΠ΅Π½ΠΈΠΉ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏ Π½Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ. Π ΡΠ°ΠΌΠΊΠ°Ρ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅, ΠΏΠΎΠ»ΠΈΡΠΎΠΌΠ½ΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π»ΠΈΠ½Ρ ΡΠ΅Π»ΠΎΠΌΠ΅Ρ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π’Π, ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π°Π½Π°Π»ΠΈΠ·Π°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ²Π»Π΅Π½Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅Π»ΠΎΠΌΠ΅Ρ ΠΈ Π’Π β ΡΠ΅Π»ΠΎΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠ°Π·Ρ (TERT) ΠΈ Π±Π΅Π»ΠΊΠ°-1, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Ρ ΡΠ΅Π»ΠΎΠΌΠ΅ΡΠ°Π·ΠΎΠΉ ΡΠ΅Π»ΠΎΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡΡ (TEP1), ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Π² 1-ΠΉ Π³ΡΡΠΏΠΏΠ΅ Ρ ΡΡΠΎΠ²Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΠ°ΡΠΈΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄ΠΎΠΌ, ΡΠ΅Π»ΠΎΠΌΠ΅Ρ ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ Π’ΠΠ 1. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘ΠΠΠ‘ Π²ΡΡΠ²Π»Π΅Π½ ΡΠ°ΠΊΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π’Π ΠΈ Π΄Π»ΠΈΠ½Ρ ΡΠ΅Π»ΠΎΠΌΠ΅Ρ, Π΄ΠΎΠΊΠ°Π·Π°Π½Π° ΠΈΡ
ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Ρ ΡΡΠΎΠ²Π½Π΅ΠΌ ΡΠ°ΡΡΡΠ°ΡΠΈΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΈ ΠΈΠ½ΡΠ΅ΡΠΌΠΈΡΡΠΈΡΡΡΡΠ΅ΠΉ Π½ΠΎΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ L-ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π° Π½Π° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ ΡΡΠ½ΠΊΡΠΈΠΉ Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π°Π΄Π΅ΡΠΆΠ΅ΠΊ ΠΏΡΠΈΡ ΠΎΡΠ΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ
The purpose of this study is to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3β7 years with delayed psycho-speech development (DPSD). The main group consisted of 37 children (25 male and 12 female), a control group β 43 patients (30 male and 13 female). Both groups of children were comparable in age, sex, degree of speech and cognitive impairment, and IQ level. Patients in the main group have taken standard therapy with L-tryptophan (25β50 mg per day depending on the age) supplement for 14 days. Control patients have taken standard therapy only. Psychodiagnostic tests at the entrance and exit of patients from this study was carried out for evaluation the dynamics of cognitive functions. All differences were considered significant at p < 0.05.Results. The study suggests that oral L-tryptophan intake selectively affects the dynamics of cognitive performance in children with DPSD. So, we studied pre- and post-treatment cognitive performance in both group patients and noted a significant improvement in the visual memory (p < 0.001) and an increase in thinking productivity (p < 0.001) in the tryptophan group versus similar indicators in the control group. Intergroup differences (p < 0.001 and p = 0.026, respectively, for the main and control groups) also found.Conclusion. Two-week L-tryptophan intake in complex therapy of DPSD in children can significantly improve the cognitive activity, and greatly increase both the effectiveness and sustainability of treatment outcomes, which will significantly reduce the time and frequency of hospitalization and financial costs for the rehabilitation of this patients.Β Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΡΠ΅Π½ΠΊΠ° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ L-ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π°, ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΠΎΠ³ΠΎ Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π°Π΄Π΅ΡΠΆΠ΅ΠΊ ΠΏΡΠΈΡ
ΠΎΡΠ΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ, Π²Π»ΠΈΡΡΡ Π½Π° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 80 Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 3β7 Π»Π΅Ρ Ρ Π·Π°Π΄Π΅ΡΠΆΠΊΠΎΠΉ ΠΏΡΠΈΡ
ΠΎΡΠ΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ (ΠΠΠ Π ). ΠΡΠ½ΠΎΠ²Π½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 37 Π΄Π΅ΡΠ΅ΠΉ (25 ΠΌΠ°Π»ΡΡΠΈΠΊΠΎΠ² ΠΈ 12 Π΄Π΅Π²ΠΎΡΠ΅ΠΊ), ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ β 43 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (30 ΠΌΠ°Π»ΡΡΠΈΠΊΠΎΠ² ΠΈ 13 Π΄Π΅Π²ΠΎΡΠ΅ΠΊ). ΠΠ±Π΅ Π³ΡΡΠΏΠΏΡ Π΄Π΅ΡΠ΅ΠΉ Π±ΡΠ»ΠΈ ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡ ΠΏΠΎ ΠΏΠΎΠ»Ρ, Π²ΠΎΠ·ΡΠ°ΡΡΡ, ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΠ΅ΡΠ΅Π²ΠΎΠΉ ΠΈ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ, ΡΡΠΎΠ²Π½Ρ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡΠ°. ΠΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΡΡ ΠΏΡΠΈΠ΅ΠΌ L-ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π° Π² ΡΡΡΠΎΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 25β50 ΠΌΠ³/ΠΊΠ³ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 14 Π΄Π½Π΅ΠΉ. ΠΠ°ΡΠΈΠ΅Π½ΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ»Π΅ΡΠ΅Π½Ρ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ ΡΡ
Π΅ΠΌΠ΅ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΠΠ Π . ΠΡΠ΅Π½ΠΊΠ° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΈΡ
ΠΎΠ΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΡΠΎΠ² Π½Π° Π²Ρ
ΠΎΠ΄Π΅ ΠΈ Π²ΡΡ
ΠΎΠ΄Π΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈΠ· Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π·Π»ΠΈΡΠΈΠΉ ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π»ΠΈ Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΡ p < 0,05.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΡΡΠΈΠΏΡΠΎΡΠ°Π½ ΠΈΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΠ΅Ρ Π½Π° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈ Π·Π°Π΄Π΅ΡΠΆΠΊΠ°Ρ
ΠΏΡΠΈΡ
ΠΎΡΠ΅ΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ. Π’Π°ΠΊ, ΠΏΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΠΠ Π Π΄ΠΎ ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΊΡΡΡΠ° ΡΠ΅ΡΠ°ΠΏΠΈΠΈ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅ΠΉ ΠΏΡΠΈΠ΅ΠΌ L-ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π°, ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ Π·ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ (p < 0,001) ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΌΡΡΠ»Π΅Π½ΠΈΡ (p < 0,001) ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π°Π½Π°Π»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΡΠΎΠ»Π΅ΡΠ΅Π½Π½ΡΡ
Π±Π΅Π· Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ. ΠΡΠΈ ΡΡΠΎΠΌ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΠΎΡΠ»ΠΈΡΠΈΡ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΈ ΠΏΡΠΈ ΠΌΠ΅ΠΆΠ³ΡΡΠΏΠΏΠΎΠ²ΠΎΠΌ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ (p < 0,001 ΠΈ p = 0,026 ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ Π΄Π»Ρ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏ).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π‘Π»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎ, Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ L-ΡΡΠΈΠΏΡΠΎΡΠ°Π½Π° Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΠΠ Π Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎ Π·Π°ΠΌΠ΅ΡΠ½ΠΎ ΡΠ»ΡΡΡΠΈΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΠΊΠ°ΠΊ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΡΠ°ΠΊ ΠΈ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠΎΠΊΡΠ°ΡΠΈΡΡ ΡΡΠΎΠΊΠΈ ΠΈ ΠΊΡΠ°ΡΠ½ΠΎΡΡΡ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΡΠ΅ ΠΈΠ·Π΄Π΅ΡΠΆΠΊΠΈ Π½Π° ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ².