The fundamentals of the measurement of the dosimetric quantities in hadrontherapy

Published in: Proceedings of the 14th Joint International IMEKO TC1 + TC7 + TC 13 Symposium : "Intelligent quality measurements - theory, education and training" ; in conjunction with the 56th IWK, Ilmenau University of Technology and the 11th SpectroNet Collaboration Forum ; 31. August - 2. September 2011, JenTower Jena, Germany. - Ilmenau : Univ.-Bibliothek, ilmedia, 2011. URN: urn:nbn:de:gbv:ilm1-2011imeko:

Microbiostratigraphie (foraminifères) et reconstitution paléoenvironnementale de la Formation marine de Chechiș (Miocène inférieur) dans le Bassin Transylvanien

Planktonic and benthic foraminiferal assemblages were used for biostratigraphy and paleoenvironmental reconstruction of the marine lower Miocene Chechiș Formation from the Gălpâia section (Sălaj county, Romania) in the northwestern Transylvanian Basin. Planktonic foraminifera suggest an Eggenburgian (Burdigalian) age for the deposits studied and reveal episodes of high primary productivity and mostly cool surface waters. Benthic foraminiferal assemblages indicate paleoenvironmental deepening from outer shelf to upper bathyal settings. Deltaic influences may be observed at the base of the studied section in outer shelf (possibly upper bathyal) environments with oxygenated bottom water and episodic high primary productivity, as a consequence of nutrient input from the land. Changes in paleobathymetry resulted in reduction of primary productivity. The benthic assemblages from the uppermost part of the section are dominated by tubular agglutinated foraminifera and indicate an upper bathyal setting with low organic flux to the sea floor. The sediments of the studied section were deposited during the late stage of the first early Miocene relative sea-level rise in the Transylvanian Basin.Les associations de foraminifères planctoniques et benthiques sont exploitées à des fins biostratigraphiques et de reconstitution des paléoenvironnements de la Formation Chechiș du Miocène inférieur marin dans la coupe de Gălpâia (district de Sălaj, Roumanie, NW du Bassin transylvanien). Les foraminifères planctoniques suggèrent un âge eggenburgien (Burdigalien) pour les dépôts objets de cette étude. Ils révèlent en outre l'existence d'épisodes de forte productivité primaire et la présence d'eaux de surface généralement froides. Les associations de foraminifères benthiques indiquent un approfondissement des paléoenvironnements depuis le bord externe du plateau continental à la partie supérieure de l'étage bathyal. Des influences deltaïques peuvent être observées à la base de la coupe au sein des environnements du bord externe du plateau continental (peut-être même dans la partie supérieure de l'étage bathyal) avec des eaux de fond oxygénées et des épisodes de forte productivité primaire en raison d'apports de nutriments en provenance des terres émergées. Des variations paléobathymétriques ont entraîné une diminution de la productivité primaire. Les associations de formes benthiques de la partie sommitale de la coupe sont dominées par des foraminifères tubulaires à test agglutinant, marqueurs de la partie supérieure de l'étage bathyal, avec un faible flux de matière organique vers les fonds marins. Les sédiments de la coupe étudiée se sont déposés au cours du stade ultime de la première montée relative du niveau de la mer enregistrée au Miocène inférieur dans le Bassin transylvanien

The assessment of the measuring performances of a standard instrument for absorbed doserate in the medical applications of the ionizing radiation

Published in: Proceedings of the 14th Joint International IMEKO TC1 + TC7 + TC 13 Symposium : "Intelligent quality measurements - theory, education and training" ; in conjunction with the 56th IWK, Ilmenau University of Technology and the 11th SpectroNet Collaboration Forum ; 31. August - 2. September 2011, JenTower Jena, Germany. - Ilmenau : Univ.-Bibliothek, ilmedia, 2011. URN: urn:nbn:de:gbv:ilm1-2011imeko:

Sedimentology and biostratigraphy of the Early-Middle Miocene transition in NW Transylvanian Basin (Pâglişa and Dej sections)

The Early - Middle Miocene transition can be studied in several sections from the north-western Transylvanian Basin, across the boundary between the Hida and Dej Formations. The Pâglişa and Râpa Dracului (Dej locally outcrop) sections offer a very good record of the changes in the sedimentary facies and micropaleontological content across the boundary. The lower parts of the sections display the upper Hida Formation with prodelta fine grained sediments covered by coarser grained sediments related to a delta front progradation. Four sedimentary facies associations have been separated based on grain size and associated sedimentary structures. Micropaleontological assemblages are moderately to poorly preserved, with a low abundance and diversity. Planktonic Streptochilus pristinum is the main taxon associated with rare (\u3c 10%) calcareous benthic foraminifera (Bulimina, Bolivina, Cibibicidoides). The Dej Formation consists of stacked channel lag deposits associated with lateral accretion bars and crevasse splays followed by fall-out tuffs and redeposited low density tuffites interbedded with low density fine siliciclastics. The deposits of Dej Formation from the investigated areas were separated in four facies associations based on grain size/petrography and primary sedimentary structures. Micropaleontological assemblages contain typical early Badenian planktonic foraminifera (species of Orbulina, Praeorbulina, Globigerinoides, and Globorotalia) associated to the main phase of the marine transgresion from the beginning of the Middle Miocene

THE MEASUREMENT OF THE NATURAL RADIATION BACKGROUND IN A SALT MINE

The Unirea Salt Mine is situated at a depth of 208 meters beneath the surface of the earth that corresponds to a water-equivalent thickness of about 560 meters. It has a remarkable stability of microenvironment, characterized by a constant temperature over the year of 12.5 ±0.5 ºC and a relative humidity of 60-65 %. In order to set up a calibration laboratory in this mine, for the measuring systems dedicated to the dosimetric measurements and environment, the natural radiation background had to be measured. The measurements were made using two different dosimetric systems: An electronic type, consisting from two ratemeters: an Eberline FH 40 GL 10 and an AUTOMESS 6150 dose ratemeter with external scintillation probes; A TLD dosimetric system SD-TL type, which consists of the TL laboratory reader-analyze, 770 A type and thermoluminiscent detectors by LiF:Mg, Cu, P. The results obtained with the two systems are in good agreement

In sights into the palaeoenvironments, structure and stratigrapy of the lower Miocene of the Eastern Carpathians Bend Zone, Romania

The ages of several Oligocene to Miocene sedimentary formations from the Eastern Carpathians Bend Zone are poorly constrained due to palaeoenvironmental factors, reworking of fossils, structural complexity and limited exposure. To help overcome these issues, this study integrates calcareous nannoplankton and foraminifera biostratigraphy with isotopic age dating (U-Pb) of volcaniclastic zircons, and sedimentological and structural bservations/interpretations. Our study was carried out along an ~6-km-long section made from a series of outcrops along the Bizdidel River which exposes several formations such as the Pucioasa, Fusaru, VineÔiÍu, Starchiojd and Slon. We show that the Fusaru Formation consists of coarse-grained rocks deposited as confined longitudinal channel successions that migrated laterally. It is bounded by the mudrich Pucioasa and VineÔiÍu formations which are lateral equivalents of the Fusaru confined channels deposited as levee/overbank units. These genetically related formations appear to reach younger ages – of the lower to middle Burdigalian based on calcareous nannoplankton and foraminifera biostratigraphy – than previously thought (upper Oligocene to lower Burdigalian). The dominant organic-rich mudstones of the Starchiojd Formation represent pelagites/hemipelagites deposited in anoxic conditions. Their middle Burdigalian age is established by a 17.41 ±0.27 Ma zircon U-Pb age of zircons from the Bãtrâni Tuff in the Starchiojd Formation. Based on the similar phenocryst content, zircon U-Pb age and zircon trace element composition, the source of the tuff is suggested to be the 17.3 Ma Eger ignimbrite-forming eruption, which has proximal, near-caldera deposits in the Bükkalja Volcanic Field, Hungary. The mud-rich Slon Formation seems to be related to shelf edge/upslope failure that formed cohesive debrite avalanches resulting from foreland propagation of compression. The Slon Formation extends in this area to at least the upper part of the lower Miocene to middle Miocene. These results highlight the need to revise ages of those parts of the sequence which are poorly constrained or different in other parts of the Carpathian Basin. Such revised ages help to better constrain the understanding of the deformation history of the Carpathians

Insights into the palaeoenvironments, structure and stratigraphy of the lower Miocene of the Eastern Carpathians Bend Zone, Romania

The ages of several Oligocene to Miocene sedimentary formations from the Eastern Carpathians Bend Zone are poorly constrained due to palaeoenvironmental factors, reworking of fossils, structural complexity and limited exposure. To help overcome these issues, this study integrates calcareous nannoplankton and foraminifera biostratigraphy with isotopic age dating (U-Pb) of volcaniclastic zircons, and sedimentological and structural observations/interpretations. Our study was carried out along an ~6-km-long section made from a series of outcrops along the Bizdidel River which exposes several formations such as the Pucioasa, Fusaru, Vinețișu, Starchiojd and Slon. We show that the Fusaru Formation consists of coarse-grained rocks deposited as confined longitudinal channel successions that migrated laterally. It is bounded by the mud-rich Pucioasa and Vinețișu formations which are lateral equivalents of the Fusaru confined channels deposited as levee/overbank units. These genetically related formations appear to reach younger ages – of the lower to middle Burdigalian based on calcareous nannoplankton and foraminifera biostratigraphy – than previously thought (upper Oligocene to lower Burdigalian). The dominant organic-rich mudstones of the Starchiojd Formation represent pelagites/hemipelagites deposited in anoxic conditions. Their middle Burdigalian age is established by a 17.41 ±0.27 Ma zircon U-Pb age of zircons from the Bătrâni Tuff in the Starchiojd Formation. Based on the similar phenocryst content, zircon U-Pb age and zircon trace element composition, the source of the tuff is suggested to be the 17.3 Ma Eger ignimbrite-forming eruption, which has proximal, near-caldera deposits in the Bükkalja Volcanic Field, Hungary. The mud-rich Slon Formation seems to be related to shelf edge/upslope failure that formed cohesive debrite avalanches resulting from foreland propagation of compression. The Slon Formation extends in this area to at least the upper part of the lower Miocene to middle Miocene. These results highlight the need to revise ages of those parts of the sequence which are poorly constrained or different in other parts of the Carpathian Basin. Such revised ages help to better constrain the understanding of the deformation history of the Carpathians

Diabetes Mellitus and Other Predictors for the Successful Treatment of Metastatic Colorectal Cancer: A Retrospective Study

Background and Objectives: In the last decades there has been an increasing body of research identifying the positive correlation between diabetes mellitus (DM) and solid malignancies, moreover, having shown DM as an independent risk factor for colorectal cancer (CRC). The aim of the present study was to assess the impact of DM on metastatic CRC (mCRC), and to identify possible predictive factors in the successful treatment of mCRC. Materials and Methods: 468 patients with mCRC were included in this retrospective, observational study. A total of 8669 oncological treatment cycles related to 988 distinct chemotherapy lines were analyzed. Data regarding lines of treatment and blood panel values were obtained from the Oncohelp Hospital database. Results: The presence of DM in male patients >70 years was a negative predictor (RR = 1.66 and a p = 0.05). DM seemed to have a detrimental effect in patients whose treatment included bevacizumab (median time to treatment failure -TTF- 94 days for DM+ cases compared to 114 days for DM-patients, p = 0.07). Analysis of treatments including bevacizumab based on DM status revealed lower values of mean TTF in DM+ female patients versus DM-(81.08 days versus 193.09 days, p p = 0.06). Conclusions: The favorable predictive factors identified were the inclusion of antiangiogenic agents, a higher hemoglobin value, a higher lymphocyte count, the inclusion of anti-EGFR treatment for DM+ patients, a higher creatinine, and a higher lymphocyte count in treatment lines that included anti-EGFR treatment. Unfavorable predictive factors were represented by the presence of DM in female patients undergoing antiangiogenic treatment, neutropenia in male patients, the association of oxaliplatin and antiangiogenic agents, and a higher monocyte count in the aforementioned treatment lines