Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

Seven new cembranoids, sarcocrassocolides F–L (1–7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure–activity relationship was studied. Compounds 1–7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein

Isolement et identification de métabolites secondaires extraits d organismes marins de l Océan Indien

Les chimistes s intéressent de plus en plus aux organismes marins dépourvus de protection mécanique (carapace, coquille ) dont la survie dépend de leur capacité à émettre des substances répulsives, voire des poisons. Les spongiaires, les ascidies et les coraux mous sont ainsi producteurs de molécules souvent de structure complexe et potentiellement intéressantes pour des usages biomédicaux. Ce manuscrit présente les travaux de recherche réalisés sur cinq éponges et une ascidie récoltées dans l Océan Indien, près de Madagascar ainsi que sur un corail mou collecté à l Ile de la Réunion. D après la littérature parmi les sept organismes marins sélectionnés, six n avaient jamais été étudiés auparavant. Nos recherches ont été essentiellement axées sur la séparation et la purification de métabolites secondaires à l aide des méthodes chromatographiques usuelles ainsi que sur la caractérisation de ces métabolites à partir de différentes techniques spectroscopiques (RMN 1D, 2D, SM ). Cette étude a permis de mettre en évidence 20 composés dont 13 sont connus mais nouvellement caractérisés dans les organismes marins étudiés ainsi que 7 nouveaux composés dont la Ptilomycaline D, un épimère et un diastéréoisomère de la Plakortide N, les Flexusines A, B et C et un épimukulol.AIX-MARSEILLE3-BU Sc.St Jérô (130552102) / SudocSudocFranceF

5α,8α-Epidioxysterols from the tunicate Didemnum salary

International audienceFive α,8α-epidioxysterols were isolated and identified from the tunicate Didemnum salary. The relative quantification of the compds. obtained was 5α,8α-epidioxycholest-6-en-3β-ol (50%), 5α,8α-epidioxy-24(S)-methylcholest-6-en-3β-ol + 5α,8α-epidioxy-24(R)-methylcholest-6-en-3β-ol (30%), and 5α,8α-epidioxy-24(S)-ethylcholest-6-en-3β-ol + 5α,8α-epidioxy-24(R)-ethylcholest-6-en-3β-ol (20%). [on SciFinder(R)

7-Amino-7,8-dihydro-α-bisabolene derivatives from the marine sponge Axinyssa aplysinoides

International audience(6R,7S)-7-amino-7,8-dihydro-α-bisabolene, (6R,7S)-7-amino-7,8-dihydro-α-bisabolene-HCl, and N,N'-bis[(6R,7S)-7-amino-7,8-dihydro-α-bisabolen-7-yl]urea were isolated from the sponge Axinyssa aplysinoides and structures were detd. on the basis of 1D NMR spectra. Their chemotaxonomic significance was discussed. [on SciFinder(R)

Preparative access to transformation products (TPs) of furosemide: a versatile application of anodic oxidation

International audienc

Ptilomycalin D, a Polycyclic Guanidine Alkaloid from the Marine Sponge Monanchora dianchora

International audienceA new polycyclic guanidine alkaloid, ptilomycalin D (I), and the known crambescidic acid were isolated from the marine sponge Monanchora dianchora collected in Nosy-Be, northwest of Madagascar, in the Indian Ocean. The structures were elucidated using 1- and 2-D NMR and MS data, and their biogenetic implications are discussed. [on SciFinder(R)

5α,8α-Epidioxysterol from the marine sponge Biemna triraphis Topsent

International audience5α,8α-Epidioxy-24(S)-ethylcholest-6-en-3β-ol was isolated from the marine sponge Biemna triraphis Topsent collected at Andavadoaka, near Toliary (west coast of Madagascar-Indian Ocean). The structure was elucidated from NMR spectroscopic data. This is the first report of this compd. in a marine sponge belonging to the Biemna genus. [on SciFinder(R)

Flexusines A and B and Epimukulol from the Soft Coral Sarcophyton flexuosum

International audienceThree new cembranes, flexusines A (I) and B (II) and an epimukulol (III), were isolated from the soft coral Sarcophyton flexuosum collected near Reunion Island, Indian Ocean. Their structures were elucidated using 1D and 2D NMR spectral analyses. [on SciFinder(R)

Salaramides A and B; two α-oxoamides isolated from the marine sponge Hippospongia sp. (Porifera, Dictyoceratida)

International audienceTwo novel α-oxoamides, salaramide A (1) and its homolog salaramide B (2), were isolated from the Madagascar marine sponge, Hippospongia sp., collected in Salary Bay, north of Tulear. The structures of 1 and 2 were elucidated by interpretation of mass spectra, 1D and 2D NMR spectra, and confirmed by chem. transformation. [on SciFinder(R)