Optimal co-occurrence matrix for automatic segmentation of ultrasonic images

This paper introduces a new method of segmentation using automatic thresholding adapted to the NDT ultrasonic images . This study is based on image analysis through co-occurrence matrixes . It shows an optimization of the r and 0 parameters of the co-occurrence matrix enabling to define more acurately the border between noise and defect echoes . The segmentation is obtained by automatically taking into account a threshold derived from a determination curve calculated front the co-occurrence matrix . This curve, called Average Product of Variances Measure, is an analysis of the distribution of the matrix coefficients . The results show behaviors of the co-occurrence matrixes and of the threshold selection curves that justify perfectly the analysis performed on the characteristics of the image .Cet article présente une nouvelle méthode de segmentation par seuillage automatique, adaptée aux images obtenues en contrôle non destructif par ultrasons. Cette étude est fondée sur l'analyse d'image par matrice de co-occurrence. On présente une optimisation des paramètres r et Θ de la matrice de co-occurrence permettant de mieux définir la frontière qui sépare le bruit des échos de défauts. La segmentation s'obtient par la prise en compte automatique d'un seuil issu d'une courbe de détermination calculée à partir de la matrice de co-occurrenc

Nanosized superconducting constrictions

Nanowires of lead between macroscopic electrodes are produced by means of an STM. Magnetic fields may destroy the superconductivity in the electrodes, while the wire remains in the superconducting state. The properties of the resulting microscopic Josephson junctions are investigated.Comment: 3 pages,3 eps figures include

Mesoscopic superconductors in the London limit: equilibrium properties and metastability

We present a study of the behaviour of metastable vortex states in mesoscopic superconductors. Our analysis relies on the London limit within which it is possible to derive closed analytical expressions for the magnetic field and the Gibbs free energy. We consider in particular the situation where the vortices are symmetrically distributed along a closed ring. There, we obtain expressions for the confining Bean-Livingston barrier and for the magnetization which turns out to be paramagnetic away from thermodynamic equilibrium. At low temperature, the barrier is high enough for this regime to be observable. We propose also a local description of both thermodynamic and metastable states based on elementary topological considerations; we find structural phase transitions of vortex patterns between these metastable states and we calculate the corresponding critical fields.Comment: 24 pages, 20 figure

Vortex matter in superconducting mesoscopic disks: Structure, magnetization, and phase transitions

The dense vortex matter structure and associated magnetization are calculated for type-II superconducting mesoscopic disks. The magnetization exhibits generically first-order phase transitions as the number of vortices changes by one and presents two well-defined regimes: A non-monotonous evolution of the magnitude of the magnetization jumps signals the presence of a vortex glass structure which is separated by a second-order phase transition at $H_{c2}$ from a condensed state of vortices (giant vortex) where the magnitude of the jumps changes monotonously. We compare our results with Hall magnetometry measurements by Geim et al. (Nature 390, 259 (1997)) and claim that the magnetization exhibits clear traces of the presence of these vortex glass states.Comment: 4 pages, 3 figure

Locally Biased Galaxy Formation and Large Scale Structure

We examine the influence of the morphology-density(MD) relation and a wide range of simple models for biased galaxy formation on statistical measures of large scale structure. We contrast the behavior of local biasing models, in which the efficiency of galaxy formation is determined by density, geometry, or velocity dispersion of the local mass distribution, with that of non-local biasing models, in which galaxy formation is modulated coherently over scales larger than the galaxy correlation length. If morphological segregation of galaxies is governed by a local MD relation, then the correlation function of E/S0 galaxies should be steeper and stronger than that of spiral galaxies on small scales, as observed, while on large scales the correlation functions of E/S0 and spiral galaxies should have the same shape but different amplitudes. Similarly, all of our local bias models produce scale-independent amplification of the correlation function and power spectrum in the linear and mildly non-linear regimes; only a non-local biasing mechanism can alter the shape of the power spectrum on large scales. Moments of the biased galaxy distribution retain the hierarchical pattern of the mass moments, but biasing alters the values and scale-dependence of the hierarchical amplitudes S3 and S4. Pair-weighted moments of the galaxy velocity distribution are sensitive to the details of the biasing prescription. The non-linearity of the relation between galaxy density and mass density depends on the biasing prescription and the smoothing scale, and the scatter in this relation is a useful diagnostic of the physical parameters that determine the bias. Although the sensitivity of galaxy clustering statistics to the details of biasing is an obstacle to testing cosmological models, it is an asset for testing galaxy formation theories.Comment: 47 pages including 17 Figures, submitted to Ap

Mesoscopic Superconducting Disc with Short-Range Columnar Defects

Short-range columnar defects essentially influence the magnetic properties of a mesoscopic superconducting disc.They help the penetration of vortices into the sample, thereby decrease the sample magnetization and reduce the upper critical field. Even the presence of weak defects split a giant vortex state (usually appearing in a clean disc in the vicinity of the transition to a normal state) into a number of vortices with smaller topological charges. In a disc with a sufficient number of strong enough defects vortices are always placed onto defects. The presence of defects lead to the appearance of additional magnetization jumps related to the redistribution of vortices which are already present on the defects and not to the penetration of new vortices.Comment: 14 pgs. RevTex, typos and figures corrected. Submitted to Phys. Rev.

Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer

BACKGROUND AND OBJECTIVE: Up to 90% of patients with castration-resistant prostate cancer (CRPC) will develop symptomatic bone metastases requiring pain medication, with opioids being the mainstay of therapy in treating moderate and severe pain. Enzalutamide is an androgen receptor antagonist for the treatment of CRPC and a strong inducer of cytochrome P450 (CYP)3A4. Hereby, enzalutamide potentially reduces the exposure of oxycodone, an opioid metabolized by CYP3A4 and CYP2D6. Our objective was to evaluate the potential drug-drug interaction of enzalutamide and oxycodone.METHODS: A prospective, nonrandomized, open-label, two-arm parallel study was performed. All patients received a single dose of 15 mg normal-release oxycodone. Patients in the enzalutamide arm (ENZ-arm) received enzalutamide 160 mg once daily. Plasma concentrations of oxycodone and its metabolites were quantified using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method.RESULTS: Twenty-six patients (13 ENZ-arm; 13 control arm) were enrolled in the study. Enzalutamide decreased the mean AUC 0-8 h and C max of oxycodone with, respectively, 44.7% (p &lt; 0.001) and 35.5% (p = 0.004) compared with the control arm. The AUC 0-8 h and C max of the active metabolite oxymorphone were 74.2% (p &lt; 0.001) and 56.0% (p = 0.001) lower in the ENZ-arm compared with the control arm. In contrast, AUC 0-8 h and C max of the inactive metabolites noroxycodone and noroxymorphone were significantly increased by enzalutamide. CONCLUSION: Co-administration of enzalutamide significantly reduced exposure to oxycodone and its active metabolite oxymorphone in men with prostate cancer. This should be taken into account when prescribing enzalutamide combined with oxycodone.</p

A dual point description of mesoscopic superconductors

We present an analysis of the magnetic response of a mesoscopic superconductor, i.e. a system of sizes comparable to the coherence length and to the London penetration depth. Our approach is based on special properties of the two dimensional Ginzburg-Landau equations, satisfied at the dual point $(\kappa = \frac{1}{\sqrt{2}}).$ Closed expressions for the free energy and the magnetization of the superconductor are derived. A perturbative analysis in the vicinity of the dual point allows us to take into account vortex interactions, using a new scaling result for the free energy. In order to characterize the vortex/current interactions, we study vortex configurations that are out of thermodynamical equilibrium. Our predictions agree with the results of recent experiments performed on mesoscopic aluminium disks.Comment: revtex, 20 pages, 9 figure

ESO Imaging Survey. The Stellar Catalogue in the Chandra Deep Field South

(abridged) Stellar catalogues in five passbands (UBVRI) over an area of approximately 0.3 deg^2, comprising about 1200 objects, and in seven passbands (UBVRIJK) over approximately 0.1 deg^2, comprising about 400 objects, in the direction of the Chandra Deep Field South are presented. The 90% completeness level of the number counts is reached at approximately U = 23.8, B = 24.0, V = 23.5, R = 23.0, I = 21.0, J = 20.5, K = 19.0. A scheme is presented to select point sources from these catalogues, by combining the SExtractor parameter CLASS_STAR from all available passbands. Probable QSOs and unresolved galaxies are identified by using the previously developed \chi^2-technique (Hatziminaoglou et al 2002), that fits the overall spectral energy distributions to template spectra and determines the best fitting template. The observed number counts, colour-magnitude diagrams, colour-colour diagrams and colour distributions are presented and, to judge the quality of the data, compared to simulations based on the predictions of a Galactic Model convolved with the estimated completeness functions and the error model used to describe the photometric errors of the data. The resulting stellar catalogues and the objects identified as likely QSOs and unresolved galaxies with coordinates, observed magnitudes with errors and assigned spectral types by the $\chi^2$-technique are presented and are publicly available.Comment: Paper as it will appear in print. Complete figures and tables can be obtained from: http://www.eso.org/science/eis/eis_pub/eis_pub.html. Astronomy & Astrophysics, accepted for publicatio

Mark correlations: relating physical properties to spatial distributions

Mark correlations provide a systematic approach to look at objects both distributed in space and bearing intrinsic information, for instance on physical properties. The interplay of the objects' properties (marks) with the spatial clustering is of vivid interest for many applications; are, e.g., galaxies with high luminosities more strongly clustered than dim ones? Do neighbored pores in a sandstone have similar sizes? How does the shape of impact craters on a planet depend on the geological surface properties? In this article, we give an introduction into the appropriate mathematical framework to deal with such questions, i.e. the theory of marked point processes. After having clarified the notion of segregation effects, we define universal test quantities applicable to realizations of a marked point processes. We show their power using concrete data sets in analyzing the luminosity-dependence of the galaxy clustering, the alignment of dark matter halos in gravitational $N$-body simulations, the morphology- and diameter-dependence of the Martian crater distribution and the size correlations of pores in sandstone. In order to understand our data in more detail, we discuss the Boolean depletion model, the random field model and the Cox random field model. The first model describes depletion effects in the distribution of Martian craters and pores in sandstone, whereas the last one accounts at least qualitatively for the observed luminosity-dependence of the galaxy clustering.Comment: 35 pages, 12 figures. to be published in Lecture Notes of Physics, second Wuppertal conference "Spatial statistics and statistical physics