Human Rights, Think Aloud Protocols and Magic Drums: Revealing Character in Pre-Service Teachers

This paper describes a qualitative study that examined how preservice teachers engaged in a Second Life activity intended to help them reflect on how knowledge of human rights may affect their professional practice. This process utilized a problem-solving strategy to determine their goal-oriented character traits. Therefore, the research question explored was, how do preservice teachers create a character that respects human rights? Through a symbolic introspective journey, participants engaged in think aloud protocols to reveal goal-oriented behavior guided by a strong moral compass. Data analysis utilized a means-end process, and results were recorded along two dimensions: stability and change and named insights. The first indicated a general inclination toward a persistent character with goals defined, while the second revealed insights into personal character traits that potentially aid or hinder achieving a goal, and as a result, possibly transfer to real world action

Does presenting perpetrator and innocent suspect faces from different facial angles influence the susceptibility of eyewitness memory? An investigation into the misinformation effect and eyewitness misidentification

Introduction: This study investigated the effects of face angle congruency across stages of a misinformation paradigm on lineup discrimination accuracy.Methods: In a between-subjects design, participants viewed a mock crime with the perpetrator’s face from the front or profile angle. They then read a news report featuring an innocent suspect’s image from the same or different angle as the perpetrator had been shown. A subsequent lineup manipulated perpetrator presence and viewing angle of the lineup members, who were all shown either from the front or in profile.Results: No significant difference emerged in identification errors based on angle congruency between stages. However, accuracy was higher when faces were shown from the front angle, both during the initial event and the lineup, compared to the profile angle.Discussion: The results of this research underscore the importance of considering viewing angles in the construction of lineups

Public Perceptions of Smoking in the Workplace

Introduction: Important public health policy decisions must be based on reliable epidemiologic studies and evidence-based medicine. In the effort to ban smoking in the workplace, there must be clear evidence from the constituency that such laws are desired. Current Vermont law states: Employers may designate up to 30 percent of an employee cafeteria or lounge as a smoking area and may permit smoking in designated unenclosed areas only if … smoking will not be a physical irritant to any non-smoking employee, and 75 percent of the employees in the designated areas agree to allow smoking. State legislators must address this issue for several reasons: * Long term effects including lung cancer, emphysema, heart and neurologic disease. * Secondhand smoke contains at least 250 chemicals known to be toxic, including more than 50 that can cause cancer. * The total cost of secondhand smoke exposure in the U.S. at $10 billion annually,$5 billion in direct medical costs, and $5 billion in indirect costs such as lost productivity. * Methods to reduce the effect of secondhand smoke, such as ventilators are ineffective. * One study found a 17% increased risk of developing lung cancer with smoking exposure in the workplace. Regardless, Vermonters continue to smoke; as of 2007, 18% of Vermont’s adults were smokers. Such information is important in making legislative decisions that affect the entire Vermont populationhttps://scholarworks.uvm.edu/comphp_gallery/1019/thumbnail.jp

Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors.

IL-1 is a powerful cytokine that drives inflammation and modulates adaptive immunity. Both IL-1α and IL-1β are translated as proforms that require cleavage for full cytokine activity and release, while IL-1α is reported to occur as an alternative plasma membrane-associated form on many cell types. However, the existence of cell surface IL-1α (csIL-1α) is contested, how IL-1α tethers to the membrane is unknown, and signaling pathways controlling trafficking are not specified. Using a robust and fully validated system, we show that macrophages present bona fide csIL-1α after ligation of TLRs. Pro-IL-1α tethers to the plasma membrane in part through IL-1R2 or via association with a glycosylphosphatidylinositol-anchored protein, and can be cleaved, activated, and released by proteases. csIL-1α requires de novo protein synthesis and its trafficking to the plasma membrane is exquisitely sensitive to inhibition by IFN-γ, independent of expression level. We also reveal how prior csIL-1α detection could occur through inadvertent cell permeabilisation, and that senescent cells do not drive the senescent-associated secretory phenotype via csIL-1α, but rather via soluble IL-1α. We believe these data are important for determining the local or systemic context in which IL-1α can contribute to disease and/or physiological processes.Work was funded by British Heart Foundation Grants FS/13/3/30038, FS/18/19/33371 and RG/16/8/32388 to MCHC, the BHF Cambridge CRE RE/13/6/30180, and the Cambridge NIHR Biomedical Research Centr

Building the field of health policy and systems research: framing the questions.

In the first of a series of articles addressing the current challenges and opportunities for the development of Health Policy & Systems Research (HPSR), Kabir Sheikh and colleagues lay out the main questions vexing the field

Building the Field of Health Policy and Systems Research: An Agenda for Action

In the final article in a series addressing the current challenges and opportunities for the development of Health Policy and Systems Research (HPSR), Sara Bennett and colleagues lay out an agenda for action moving forward

Using service design to co-create a digital strategy to improve tertiary education participation amongst under-represented markets

Participation in tertiary education is an important factor in achieving social parity and access to opportunity for Australians. The current government agenda is to increase participation amongst low socio-economic, culturally and linguistic diverse, Indigenous and remote peoples to be representative of their proportion in the population. This paper draws on the field of service design to bring an innovative approach to developing social marketing strategy. This research reports the findings of two qualitative studies involving 211 participants across Australia to elicit a psychologically based approach to segmentation and generate innovative digital solutions that will increase applications to participate in tertiary education. This work is the result of a multi-disciplinary team that brought together practioners from the widening participation and equity fields along with social marketers and service marketers

Effect of co-trimoxazole on mortality in HIV-exposed but uninfected children in Botswana (the Mpepu Study): a double-blind, randomised, placebo-controlled trial

Background Co-trimoxazole prophylaxis reduces mortality among HIV-infected children, but efficacy in HIV-exposed but uninfected (HEU) children in a non-malarial, low-breastfeeding setting with a low risk of mother-to-child transmission of HIV is unclear. Methods HEU children in Botswana were randomly assigned to receive co-trimoxazole (100 mg/20 mg once daily until age 6 months and 200 mg/40 mg once daily thereafter) or placebo from age 14–34 days to age 15 months. Mothers chose whether to breastfeed or formula feed their children. Breastfed children were randomly assigned to breastfeeding for 6 months (Botswana guidelines) or 12 months (WHO guidelines). The primary outcome, analysed by a modified intention-to-treat approach, was cumulative child mortality from treatment assignment to age 18 months. We also assessed HIV-free survival by duration of breastfeeding. This trial is registered with ClinicalTrials.gov, number NCT01229761. Findings From June 7, 2011, to April 2, 2015, 2848 HEU children were randomly assigned to receive co-trimoxazole (n=1423) or placebo (n=1425). The data and safety monitoring board stopped the study early because of a low likelihood of benefit with co-trimoxazole. Only 153 (5%) children were lost to follow-up (76 in the co-trimoxazole group and 77 in the placebo group), and 2053 (72%) received treatment continuously to age 15 months, death, or study closure. Mortality after the start of study treatment was similar in the two study groups: 30 children died in the co-trimoxazole group, compared with 34 in the placebo group (estimated mortality at 18 months 2·4% vs 2·6%; difference –0·2%, 95% CI –1·5 to 1·0, p=0·70). We saw no difference in hospital admissions between groups (12·5% in the cotrimoxazole group vs 17·4% in the placebo group, p=0·19) or grade 3–4 clinical adverse events (16·5% vs 18·4%, p=0·18). Grade 3–4 anaemia did not differ between groups (8·1% vs 8·3%, p=0·93), but grade 3–4 neutropenia was more frequent in the co-trimoxazole group than in the placebo group (8·1% vs 5·8%, p=0·03). More co-trimoxazole resistance in commensal Escherichia coli isolated from stool samples was seen in children aged 3 or 6 months in the co-trimoxazole group than in the placebo group (p=0·001 and p=0·01, respectively). 572 (20%) children were breastfed. HIV infection and mortality did not differ significantly by duration of breastfeeding (3·9% for 6 months vs 1·9% for 12 months, p=0·21). Interpretation Prophylactic co-trimoxazole seems to offer no survival benefit among HEU children in non-malarial, low-breastfeeding areas with a low risk of mother-to-child transmission of HIV

Use of Ionic Liquids in Rod-Coil Block Copolyimides for Improved Lithium Ion Conduction

Solvent-free, solid polymer electrolytes (SPE) have the potential to improve safety, increase design flexibility and enhance performance of rechargeable lithium batteries. Solution based electrolytes are flammable and typically incompatible with lithium metal anodes, limiting energy density. We have previously demonstrated use of polyimide rod coil block copolymers doped with lithium salts as electrolytes for lithium polymer batteries. The polyimide rod blocks provide dimensional stability while the polyethylene oxide (PEO) coil portions conduct ions. Phase separation of the rods and coils in these highly branched polymers provide channels with an order of magnitude improvement in lithium conduction over polyethylene oxide itself at room temperature. In addition, the polymers have been demonstrated in coin cells to be compatible with lithium metal. For practical use at room temperature and below, however, at least an order of magnitude improvement in ion conduction is still required. The addition of nonvolatile, room temperature ionic liquids has been shown to improve the ionic conductivity of high molecular weight PEO. Herein we describe use of these molten salts to improve ionic conductivity in the rod-coil block copolymers

Concert recording 2013-12-05a

[Track 01]. Introduction -- [Track 02]. Papageno\u27s aria, Die Zauberflote / Wolfgang Amadeus Mozart -- [Track 03]. Canzonetta sull\u27aria, Le nozze di Figaro / Wolfgang Amadeus Mozart -- [Track 04]. Tutto e diposto...Aprite un po\u27 quegl\u27occhi, Le nozze di Figaro / Wolfgang Amadeus Mozart -- [Track 05]. Oh goodness me, what misery, Die Fledermaus / Johann Strauss -- [Track 06]. Parle-moi de ma mere, Carmen / Georges Bizet -- [Track 07]. Nous avons en tete une affaire, Carmen / Georges Bizet -- [Track 08]. Melons, coupons, Carmen / Georges Bizet -- [Track 09]. You are not rich, La Perichole / Jacques Offenbach -- [Track 10]. Alla bella despinetta, Cosi fan tutte / Wolfgang Amadeus Mozart -- [Track 11]. When I lay me down to sleep, Hansel and Gretel / Engelbert Humperdinck