3,635 research outputs found

    The motivation and status of two-body resonance decays after the LHC Run 2 and beyond

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    Searching for two-body resonance decays is a central component of the high energy physics energy frontier research program. While many of the possibilities are covered when the two bodies are Standard Model (SM) particles, there are still significant gaps. If one or both of the bodies are themselves non-SM particles, there is very little coverage from existing searches. We review the status of two-body searches and motivate the need to search for the missing combinations. It is likely that the search program of the future will be able to cover all possibilities with a combination of dedicated and model agnostic search approaches.Comment: 17 pages, 1 figure, 14 table

    A Topological Method for Comparing Document Semantics

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    Comparing document semantics is one of the toughest tasks in both Natural Language Processing and Information Retrieval. To date, on one hand, the tools for this task are still rare. On the other hand, most relevant methods are devised from the statistic or the vector space model perspectives but nearly none from a topological perspective. In this paper, we hope to make a different sound. A novel algorithm based on topological persistence for comparing semantics similarity between two documents is proposed. Our experiments are conducted on a document dataset with human judges' results. A collection of state-of-the-art methods are selected for comparison. The experimental results show that our algorithm can produce highly human-consistent results, and also beats most state-of-the-art methods though ties with NLTK.Comment: 9 pages, 3 tables, 9th International Conference on Natural Language Processing (NLP 2020

    Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles.

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    Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma. However, a possible role of these drugs in altering morphology and distribution of cholesterol particles is poorly understood. Here, we describe the in vitro evaluation of lipid-lowering drug effects in modulating morphological features of cholesterol particles using the plaque array method in combination with imaging flow cytometry. Image analyses of the cholesterol particles indicated that lovastatin, simvastatin, ezetimibe, and atorvastatin induce the formation of both globular and linear strand-shaped particles, whereas niacin, fibrates, fluvastatin, and rosuvastatin induce the formation of only globular-shaped particles. Next, purified very low-density lipoprotein (VLDL) and LDL particles incubated with these drugs showed changes in the morphology and image texture of cholesterol particles subpopulations. Furthermore, screening of 50 serum samples revealed the presence of a higher level of linear shaped HDL cholesterol particles in subjects with dyslipidemia (mean of 18.3%) compared to the age-matched normal (mean of 11.1%) samples. We also observed considerable variations in lipid-lowering drug effects on reducing linear shaped LDL and HDL cholesterol particles formation in serum samples. These findings indicate that lipid-lowering drugs, in addition to their cell-mediated hypolipidemic effects, may directly modulate morphology of cholesterol particles by a non-enzymatic mechanism of action. The outcomes of these results have potential to inform diagnosis of atherosclerosis and predict optimal lipid-lowering therapy

    The motivation and status of two-body resonance decays after the LHC Run 2 and beyond

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    Searching for two-body resonance decays is a central component of the high energy physics energy frontier research program. While many of the possibilities are covered when the two bodies are Standard Model (SM) particles, there are still significant gaps. If one or both of the bodies are themselves non-SM particles, there is very little coverage from existing searches. We review the status of two-body searches and motivate the need to search for the missing combinations. It is likely that the search program of the future will be able to cover all possibilities with a combination of dedicated and model agnostic search approaches

    Working to define data curated geospatial services on a Research Campus, a Purdue University Libraries Example

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    As Data Curation is becoming a necessity of data science and library science, Purdue University Libraries has been a leader in data curation profiles research. Such research can be defined as a data stewardship protocol similar to a multiple use case analysis. In this this example, The Purdue University Libraries Geographical Information Systems (GIS) department has engaged in a data curation profiles assessment of the campus to baseline and qualify sustainable geospatial data services

    GIS and Data Curation Librarianship: Mobile Dissemination of GIS Resources

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    The Purdue University Librariesā€™ GIS department is working to advance geospatial services campus wide. In addition to conducting data curation profiles research in an IRB approved manner, we aim to validate new ways and means to make GIS services viable for large and diverse student and faculty community of over 40,000 students, all departments and along interdisciplinary boundaries. Here is a prototype of our mobile dissemination GIS of services and development in collaboration with Aalto University Library. Here, we discuss in a 3-fold manner how the GIS Dept. has prototyped a means of mobile GIS knowledge dissemination towards the development of library-led campus wide geospatial data services for future considerations. Such may offer timely and low cost data navigation of GIS resources using oneā€™s smartphone or tablet device

    Libraries as Advocates of Citizen Science Awareness on Emerging Open Geoscience Platforms in Finnish Society - International Collaboration for Promoting Open Geoscience Content in Finnish University Libraries

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    In the Finnish National Spatial Strategy 2010-2015, the Finlandā€™s Ministry of Agriculture and Forestry delineated that spatial data skills should support citizens everyday activities and facilitate decision-making and participation of citizens. The emerging of new open data infrastructures, a trend further driven by European Unionā€™s policies, calls out for an institution to link to the new possibilities of these resources with the myriad of their possible user groups. The following framework examines open geoscience platforms and open data trends affecting Finnish libraries, and discusses the possible role of Finnish university libraries as advocates of citizen science awareness of these emerging resources. The framework also examines the benefits derived from an international collaboration on data advocacy between Aalto University Libraries and Purdue University Libraries

    Reorganizing the relationship of digital library resources and physical learning environments

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    Introduction. This preliminary study examines the application of contemporary practice-based approaches to generate data for guiding the design of information literacy learning environments. Method. This study was conducted by interviewing three engineering students who were participating at the Tools for masterā€™s thesis course arranged by Aalto University Libraryā€™s Otaniemi Campus Library. The interviewā€™s structure was two-fold, as it first sketched out the participantā€™s masterā€™s thesis practices through Schatzkiā€™s site ontology and secondly examined the perceived value of different information literacy learning tasks on the latter. Results. The masterā€™s thesis practices of the interviewees were networked in complex ways with e.g. economic life and the interviewees invested much in them. Two of the interviewees worked with their thesis full-time with surroundings and tools provided by their employer. The interviewees valued most the lecture, which comprised of narratives of completed masterā€™s thesis projects and the lecture of scientific writing. From the asynchronous online learning tasks, the interviewees valued most the information retrieval task and the concept map exercise. Conclusion. Spatial library spaces could be provided with asynchronous content such as descriptions of the library services through the tasks of the central user groups and e.g. introductory videos to information retrieval techniques. These contents could be spatially located so that they would serve as facile entrance points to the mobile digital library. The practice-based approaches seem to provide a fertile way of examining student learning and insights gained through them may prove to be valuable in designing new information literacy learning environments.Peer reviewe

    Diversity of group B streptococcus serotypes causing urinary tract infection in adults

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    Serotypes of group B streptococcus (GBS) that cause urinary tract infection (UTI) are poorly characterized. We conducted a prospective study of GBS UTI in adults to define the clinical and microbiological characteristics of these infections, including which serotypes cause disease. Patients who had GBS cultured from urine over a 1-year period were grouped according to symptoms, bacteriuria, and urinalysis. Demographic data were obtained by reviewing medical records. Isolates were serotyped by latex agglutination and multiplex PCRreverse line blotting (mPCR/RLB). Antibiotic susceptibilities were determined by disc diffusion. GBS was cultured from 387/34,367 consecutive urine samples (1.1%): 62 patients had bacteriuria of >10 7 CFU/liter and at least one UTI symptom; of these patients, 31 had urinary leukocyte esterase and pyuria (others not tested), 50 (81%) had symptoms consistent with cystitis, and 12 (19%) had symptoms of pyelonephritis. Compared with controls (who had GBS isolated without symptoms), a prior history of UTI was an independent risk factor for disease. Increased age was also significantly associated with acute infection. Serotyping results were consistent between latex agglutination and mPCR/RLB for 331/387 (85.5%) isolates; 22 (5.7%) and 7 (1.8%) isolates were nontypeable with antisera and by mPCR/RLB, respectively; and 45/56 (80.4%) isolates with discrepant results were typed by mPCR/RLB as belonging to serotype V. Serotypes V, Ia, and III caused the most UTIs; serotypes II, Ib, and IV were less common. Nontypeable GBS was not associated with UTI. Erythromycin (39.5%) and clindamycin (26.4%) resistance was common. We conclude that a more diverse spectrum of GBS serotypes causes UTI than previously recognized, with the exception of nontypeable GBS
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