Histology Files

Histology File

Rabbit Data

This file contains the information on the rabbits used in the study. Any histories on the rabbit are also recorded in this file

Modified Petty scale to assess infection (i.e., external inflammation, soft tissue inflammation, bone necrosis, and osteomyelitis) during post-operative monitoring [42].

<p>Modified Petty scale to assess infection (i.e., external inflammation, soft tissue inflammation, bone necrosis, and osteomyelitis) during post-operative monitoring [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118696#pone.0118696.ref042" target="_blank">42</a>].</p

Rabbit Scoring Data Repository

This file has scoring informatio

Microbiology assessments post euthanasia.

<p>Data represent the number of animals with culture positive swabs. No bacteria were detected in the blood of any animals. Only infected cohorts are shown with the exception of Cohort 1, which was included as a non-infection comparator. Note that Cohort 2 animals were euthanized prior to all other cohorts due to evident localized infection.</p

Cohort designs for rabbit radial window defects implanted with bone graft with or without tobramycin and with or without <i>S</i>. <i>aureus</i>.

<p>* Data not presented in this manuscript.</p><p>Cohort designs for rabbit radial window defects implanted with bone graft with or without tobramycin and with or without <i>S</i>. <i>aureus</i>.</p

Schematic describing the surgical procedure for the rabbit radial BVF implant.

<p>Schematic describing the surgical procedure for the rabbit radial BVF implant.</p

Radiographs

Radiograph

Radiological analysis and callus formation (Cohorts 1, 2, and 7).

<p>Only infectious Cohorts 2 and 7 are shown for comparison while Cohort 1 is included as a non-infection comparator. The presence of a distinct boney callus in Cohorts 1 and an incomplete bridging callus in Cohort 7 are indicative of bone healing. Although soft tissue inflammation cannot be quantitatively assessed, there appeared to be little or no soft tissue inflammation in Cohort 7 compared to Cohort 1, indicating a relatively normal bone healing response. Cohort 2 shows pronounced signs of infection as the device is displaced (indicated by a red arrow).</p

Semi-quantitative histology scoring.

<p>Histology images (20x) were obtained from each rabbit and assessed based on the capsule thickness (A), qualitative bone reaction (B), periprosthetic inflammation (C), and bone ingrowth (D). * significance p ≤ 0.05</p