Holdsworth Retrofit and Renovation

The University of Massachusetts has a rapidly evolving commitment to reducing greenhouse gas emissions and improving the environmental sustainability of its operations. According to the most recent IPCC report, the buildings sector has more potential to contribute to climate change mitigation than any other sector.1 The energy efficient designs of the current spate of building projects are indicative of the University’s commitment to green building—reducing the energy intensity of the university relative to building area and activities. However, these efforts cannot reduce the total energy use or greenhouse gas emissions from current levels. Among the University’s assets with the greatest potential to achieve these goals are its existing buildings. Most of these are good buildings that have not reached the end of their useful life. Forty-two buildings, encompassing more than half of the general administration and educational space fall into the categories of “catch up and keep up” or “keep and renew” according to the university’s Building Disposition Report.2 Many of the existing buildings have great historical, aesthetic, and emotional value and have stood the test of time as the site of the academic, scientific, and cultural work that is their primary purpose. Can these buildings be updated to dramatically reduce their energy consumption and allow them to continue to function as valuable assets for the long term? What levels of energy savings are possible and reasonable? This report is designed to answer these questions for one representative building: Holdsworth Hall. The recommendations in this report are the product of a detailed and careful examination and exploration of the building and its operations. The investigations and proposed solutions are motivated by two principles: First, the architectural intention should be respected. The building as designed works well on many levels, and no recommendation should undermine currently effective systems and designs or compromise the aesthetic intention of its designers. Second, the building is a complex system, and no change can be considered in isolation. Single measures may achieve savings, but cannot maximize savings or performance without complementary changes in related systems. A final package of recommended measures will define a new building system with emergent properties that make for a qualitatively different and better building beyond simple energy consumption metrics. 1

Clinical Practice Variability in Temperature Correction of Arterial Blood Gas Measurements and Outcomes in Hypothermia-Treated Patients After Cardiac Arrest

Mechanical ventilation in patients treated with mild therapeutic hypothermia (MTH) for the postcardiac arrest syndrome may be challenging given changes in solubility of arterial blood gases (ABGs) with cooling. Whether ABG measurements should be temperature corrected (TC) remain unknown. We sought to describe practice variability in TC at a single institution and explored the association between TC and neurological outcome. We conducted a retrospective cohort study reviewing electronic health records of all patients treated with MTH after cardiac arrest. We examined whether the percentage of TC ABGs relative to total number of ABGs drawn for each subject during hypothermia was associated with the neurological outcome at hospital discharge and 6?12-month follow-up. The cerebral performance category of 1?2 was defined as a favorable outcome in the logistic regression models. 1223 ABGs were obtained during MTH on 122 subjects over 6 years. TC was never used in 72 subjects (59%; no TC group), made available in 1?74% of ABGs in 17 subjects (14%; intermediate TC group), and made available in ≥75% of ABGs in 33 subjects (27%; mostly TC group). Groups differed in the proportion of subjects with shockable presenting rhythms (47% vs. 47% vs. 76%, p=0.02) and admitting ICU (p=0.005). Favorable 6-month outcomes were more common in the mostly TC than no TC group (48% vs. 25%; OR [95% CI]: 2.9 [1.2?7.1]), but not after adjustment (OR 1.5, 95% CI 0.33?6.9). There was substantial practice variability in the temperature correction strategy. Availability of temperature-corrected ABGs was not associated with improved neurological outcomes after adjusting for covariates.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140256/1/ther.2014.0029.pd

Midface Including Le Fort Level Injuries

Le Fort fractures occur at uniform weak areas in the midface often due to blunt impact to the face. Sporting injuries are a common cause of facial trauma; however, use of protective equipment has reduced the number of sports-related injuries. All patients with traumatic injuries should be evaluated using Advanced Trauma Life Support protocol. Le Fort fractures can contribute to airway obstruction, and urgent intubation may be indicated. Surgery is indicated for most displaced Le Fort fractures to restore function and facial harmony. To facilitate reduction, the original occlusive relationship should be restored by placing the patient in MMF

Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.

CD38 genetic variation has been associated with autism spectrum disorders and social anxiety disorder, which may result from CD38's regulation of oxytocin secretion. Converging evidence has found that the rs3796863 A-allele contributes to increased social sensitivity compared to the CC genotype. The current study examined the moderating role of CD38 genetic variants (rs3796863 and rs6449182) that have been associated with enhanced (or reduced) social sensitivity on neural activation related to neuroticism, which is commonly elevated in individuals with social anxiety and depression. Adults (n = 72) with varying levels of social anxiety and depression provided biological samples for DNA extraction, completed a measure of neuroticism, and participated in a standardized emotion processing task (affect matching) while undergoing fMRI. A significant interaction effect was found for rs3796863 x neuroticism that predicted right amygdala-subgenual anterior cingulate cortex (sgACC) functional connectivity. Simple slopes analyses showed a positive association between neuroticism and right amygdala-sgACC connectivity among rs3796863 A-allele carriers. Findings suggest that the more socially sensitive rs3796863 A-allele may partially explain the relationship between a known risk factor (i.e. neuroticism) and promising biomarker (i.e. amygdala-sgACC connectivity) in the development and maintenance of social anxiety and depression

Scheduling Dynamic Parallelism On Accelerators

Resource management on accelerator based systems is complicated by the disjoint nature of the main CPU and accelerator, which involves separate memory hierarhcies, different degrees of parallelism, and relatively high cost of communicating between them. For applications with irregular parallelism, where work is dynamically created based on other computations, the accelerators may both consume and produce work. To maintain load balance, the accelerators hand work back to the CPU to be scheduled. In this paper we consider multiple approaches for such scheduling problems and use the Cell BE system to demonstrate the different schedulers and the trade-offs between them. Our evaluation is done with both microbenchmarks and two bioinformatics applications (PBPI and RAxML). Our baseline approach uses a standard Linux scheduler on the CPU, possibly with more than one process per CPU. We then consider the addition of cooperative scheduling to the Linux kernel and a user-level work-stealing approach. The two cooperative approaches are able to decrease SPE idle time, by 30 % and 70%, respectively, relative to the baseline scheduler. In both cases we believe the changes required to application level codes, e.g., a program written with MPI processes that use accelerator based compute nodes, is reasonable, although the kernel level approach provides more generality and ease of implementation, but often less performance than work stealing approach

Joint and individual analysis of breast cancer histologic images and genomic covariates

A key challenge in modern data analysis is understanding connections between complex and differing modalities of data. For example, two of the main approaches to the study of breast cancer are histopathology (analyzing visual characteristics of tumors) and genetics. While histopathology is the gold standard for diagnostics and there have been many recent breakthroughs in genetics, there is little overlap between these two fields. We aim to bridge this gap by developing methods based on Angle-based Joint and Individual Variation Explained (AJIVE) to directly explore similarities and differences between these two modalities. Our approach exploits Convolutional Neural Networks (CNNs) as a powerful, automatic method for image feature extraction to address some of the challenges presented by statistical analysis of histopathology image data. CNNs raise issues of interpretability that we address by developing novel methods to explore visual modes of variation captured by statistical algorithms (e.g. PCA or AJIVE) applied to CNN features. Our results provide many interpretable connections and contrasts between histopathology and genetics

Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types

Background: Immune infiltration of the tumor microenvironment has been associated with improved survival for some patients with solid tumors. The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear

Correlating Changes in Spot Filling Factors with Stellar Rotation: The Case of LkCa 4

We present a multi-epoch spectroscopic study of LkCa 4, a heavily spotted non-accreting T Tauri star. Using SpeX at NASA's Infrared Telescope Facility (IRTF), 12 spectra were collected over five consecutive nights, spanning $\approx$ 1.5 stellar rotations. Using the IRTF SpeX Spectral Library, we constructed empirical composite models of spotted stars by combining a warmer (photosphere) standard star spectrum with a cooler (spot) standard weighted by the spot filling factor, $f_{spot}$. The best-fit models spanned two photospheric component temperatures, $T_{phot}$ = 4100 K (K7V) and 4400 K (K5V), and one spot component temperature, $T_{spot}$ = 3060 K (M5V) with an $A_V$ of 0.3. We find values of $f_{spot}$ to vary between 0.77 and 0.94 with an average uncertainty of $\sim$0.04. The variability of $f_{spot}$ is periodic and correlates with its 3.374 day rotational period. Using a mean value for $f^{mean}_{spot}$ to represent the total spot coverage, we calculated spot corrected values for $T_{eff}$ and $L_\star$. Placing these values alongside evolutionary models developed for heavily spotted young stars, we infer mass and age ranges of 0.45-0.6 $M_\odot$ and 0.50-1.25 Myr, respectively. These inferred values represent a twofold increase in the mass and a twofold decrease in the age as compared to standard evolutionary models. Such a result highlights the need for constraining the contributions of cool and warm regions of young stellar atmospheres when estimating $T_{eff}$ and $L_\star$ to infer masses and ages as well as the necessity for models to account for the effects of these regions on the early evolution of low-mass stars.Comment: 21 pages, 9 Figures; Accepted for publication in Ap

Development of Dietary-Based Toxicity Reference Values to Assess the Risk of Chlorophacinone to Non-Target Raptorial Birds

Regulatory changes in the use of some second-generation anticoagulant rodenticides in parts of North America may result in expanded use of first-generation anticoagulant rodenticides (FGARs). Recent toxicological studies with captive raptors have demonstrated that these species are considerably more sensitive to the FGAR diphacinone than traditional avian wildlife test species (mallard, bobwhite). We have now examined the toxicity of the FGAR chlorophacinone (CPN) to American kestrels fed rat tissue mechanically amended with CPN, or rat tissue containing biologically-incorporated CPN, for 7 days. Nominal CPN concentrations in these diets were 0.15, 0.75, and 1.5 μg/g food wet weight, and actual CPN concentration in diets were analytically verified as being close to target values. Food intake was consistent among groups, body weight fluctuated by less than 6%, exposure and adverse effects were generally dose-dependent, and there were no dramatic differences in toxicity between mechanically-amended and biologically-incorporated CPN diets. Using benchmark dose statistical methods, toxicity reference values at which clotting times were prolonged in 50% of the kestrels was estimated to be about 80 μg CPN consumed/kg body weight-day for prothrombin time and 40 μg CPN/kg body weight-day for Russell’s viper venom time. Based upon carcass CPN residues reported in rodents from field baiting studies, empirical measures of food consumption in kestrels, and dietary-based toxicity reference values derived from the 7-day exposure scenario, some free-ranging raptors consuming CPN-exposed prey might exhibit coagulopathy and hemorrhage. These sublethal responses associated with exposure to environmentally realistic concentrations of CPN could compromise survival of exposed birds