5 research outputs found
Anesthesia management and patient outcomes in robotic assisted laparoscopic surgery: A single center experience
Robotic surgical techniques aimed to improve patient outcomes and satisfy patient outcomes while reducing surgical morbidity and mortality. One of the most performed surgeries, robotic assisted laparoscopic radical prostatectomy (RALRP), is characterized by many factors such as steep Trendelenburg position, and challenging access to the patient. We planned to evaluate anesthesia management and postoperative patient outcomes in RALRP. Patients planned for RALRP between January 2017 and June 2021 were included. Demographic data, additional diseases and Charlson Comorbidity Index (CCI) of the patients were recorded. The methods used in anesthesia maintenance, muscle relaxant and sugammadex dose, postoperative pain treatment protocol, duration of anesthesia and surgery, length of stay (LOS) in ICU or hospital, early postoperative complications and Clavien Dindo Classification (CDC) were evaluated by examining the follow-up forms in the intraoperative and postoperative period. Two hundred and sixteen patients underwent robotic assisted laparoscopic surgery between January 2017 and June 2021 and, 141 of them (65.3%) had RALRP. The mean age of the patients was 62.38±6.94, the body mass index was 27.60±3.94, and the mean CCI was 4.08±0.93. Total intravenous anesthesia (TIVA) (n=108, 76.6%) was mostly used for anesthesia maintenance. The median time spent during anesthesia was 278.5±63.6 minutes. The median time for surgery was 239.5±65.9 minutes. According to the CDC, grade-I was 5.7%, grade-II was 2.1%, grade-IVa 7.8%. The most common complication was acute kidney injury (11, 7.8%), followed by atelectasis (4, 2.8%). 98.6% of all patients were sent to the ward from PACU, except two. The mean LOS in hospital was 4.57±2.34 days. Robotic assisted laparoscopic radical prostatectomy is most performed surgery among all robotic surgeries. We think that, patient optimization and communication between surgeon and anesthesiologist is crucial to avoid the negative effects of steep Trendelenburg position and pneumoperitoneum in terms of improving outcome. [Med-Science 2022; 11(4.000): 1482-6
Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy
9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients
Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2: 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.
Objective:To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background:AL after RC resection often results in a permanent stoma.Methods:This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results:This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions:The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies