Quasi-Biennial variations in helioseismic frequencies: Can the source of the variation be localized?

We investigate the spherical harmonic degree (l) dependence of the "seismic" quasi-biennial oscillation (QBO) observed in low-degree solar p-mode frequencies, using Sun-as-a-star Birmingham Solar Oscillations Network (BiSON) data. The amplitude of the seismic QBO is modulated by the 11-yr solar cycle, with the amplitude of the signal being largest at solar maximum. The amplitude of the signal is noticeably larger for the l=2 and 3 modes than for the l=0 and 1 modes. The seismic QBO shows some frequency dependence but this dependence is not as strong as observed in the 11-yr solar cycle. These results are consistent with the seismic QBO having its origins in shallow layers of the interior (one possibility being the bottom of the shear layer extending 5per cent below the solar surface). Under this scenario the magnetic flux responsible for the seismic QBO is brought to the surface (where its influence on the p modes is stronger) by buoyant flux from the 11-yr cycle, the strong component of which is observed at predominantly low-latitudes. As the l=2 and 3 modes are much more sensitive to equatorial latitudes than the l=0 and 1 modes the influence of the 11-yr cycle on the seismic QBO is more visible in l=2 and 3 mode frequencies. Our results imply that close to solar maximum the main influence of the seismic QBO occurs at low latitudes (<45 degrees), which is where the strong component of the 11-yr solar cycle resides. To isolate the latitudinal dependence of the seismic QBO from the 11-yr solar cycle we must consider epochs when the 11-yr solar cycle is weak. However, away from solar maximum, the amplitude of the seismic QBO is weak making the latitudinal dependence hard to constrain.Comment: 10 pages, 6 figures, accepted for publication in MNRA

Missing bits of the solar jigsaw puzzle: small-scale, kinetic effects in coronal studies

The solar corona, anomalously hot outer atmosphere of the Sun, is traditionally described by magnetohydrodynamic, fluid-like approach. Here we review some recent developments when, instead, a full kinetic description is used. It is shown that some of the main unsolved problems of solar physics, such as coronal heating and solar flare particle acceleration can be viewed in a new light when the small-scale, kinetic plasma description methods are used.Comment: 10 pages, 6 figure

Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence

<p>Abstract</p> <p>Background</p> <p>Brd2 belongs to the bromodomain-extraterminal domain (BET) family of transcriptional co-regulators, and functions as a pivotal histone-directed recruitment scaffold in chromatin modification complexes affecting signal-dependent transcription. Brd2 facilitates expression of genes promoting proliferation and is implicated in apoptosis and in egg maturation and meiotic competence in mammals; it is also a susceptibility gene for juvenile myoclonic epilepsy (JME) in humans. The <it>brd2 </it>ortholog in <it>Drosophila </it>is a maternal effect, embryonic lethal gene that regulates several homeotic loci, including Ultrabithorax. Despite its importance, there are few systematic studies of <it>Brd2 </it>developmental expression in any organism. To help elucidate both conserved and novel gene functions, we cloned and characterized expression of <it>brd2 </it>cDNAs in zebrafish, a vertebrate system useful for genetic analysis of development and disease, and for study of the evolution of gene families and functional diversity in chordates.</p> <p>Results</p> <p>We identify cDNAs representing two paralogous <it>brd2 </it>loci in zebrafish, <it>brd2a </it>on chromosome 19 and <it>brd2b </it>on chromosome 16. By sequence similarity, syntenic and phylogenetic analyses, we present evidence for structural divergence of <it>brd2 </it>after gene duplication in fishes. <it>brd2 </it>paralogs show potential for modular domain combinations, and exhibit distinct RNA expression patterns throughout development. RNA <it>in situ </it>hybridizations in oocytes and embryos implicate <it>brd2a </it>and <it>brd2b </it>as maternal effect genes involved in egg polarity and egg to embryo transition, and as zygotic genes important for development of the vertebrate nervous system and for morphogenesis and differentiation of the digestive tract. Patterns of <it>brd2 </it>developmental expression in zebrafish are consistent with its proposed role in <it>Homeobox </it>gene regulation.</p> <p>Conclusion</p> <p>Expression profiles of zebrafish <it>brd2 </it>paralogs support a role in vertebrate developmental patterning and morphogenesis. Our study uncovers both maternal and zygotic contributions of <it>brd2</it>, the analysis of which may provide insight into the earliest events in vertebrate development, and the etiology of some forms of epilepsy, for which zebrafish is an important model. Knockdowns of <it>brd2 </it>paralogs in zebrafish may now test proposed function and interaction with homeotic loci in vertebrates, and help reveal the extent to which functional novelty or partitioning has occurred after gene duplication.</p

Histone lysine demethylases in breast cancer.

Histone lysine demethylases (KDMs) have been recently discovered in mammals and have been nicknamed "erasers" for their ability to remove methyl groups from histone substrates. In cancer cells, KDMs can activate or repress gene transcription, behaving as oncogenes or tumor suppressors depending upon the cellular context. In order to investigate the potential role of KDMs in Breast Cancer (BC), we queried the Oncomine database and determined that the expression of KDMs correlates with BC prognosis. High expression of KDM3B and KDM5A is associated with a better prognosis (no recurrence after mastectomy p=0.005 and response to docetaxel p=0.005); conversely, KDM6A is overexpressed in BC patients with an unfavorable prognosis (mortality at 1 year, p=8.65E-7). Our findings suggest that KDMs could be potential targets for BC therapy. Further, altering the interactions between KDMs and Polycomb Group genes (PcG) may provide novel avenues for therapy that specifically targets these genes in BC

FoxM1 Regulates Mammary Luminal Cell Fate

Elevated expression of FoxM1 in breast cancer correlates with an undifferentiated tumor phenotype and a negative clinical outcome. However, a role for FoxM1 in regulating mammary differentiation was not known. Here, we identify another function of FoxM1, the ability to act as a transcriptional repressor, which plays an important role in regulating the differentiation of luminal epithelial progenitors. Regeneration of mammary glands with elevated levels of FoxM1 leads to aberrant ductal morphology and expansion of the luminal progenitor pool. Conversely, knockdown of FoxM1 results in a shift toward the differentiated state. FoxM1 mediates these effects by repressing the key regulator of luminal differentiation, GATA-3. Through association with DNMT3b, FoxM1 promotes methylation of the GATA-3 promoter in an Rb-dependent manner. This study identifies FoxM1 as a critical regulator of mammary differentiation with significant implications for the development of aggressive breast cancers