Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente

Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts. Signaling by the lymphotoxin (LT)-β receptor or TNF receptor-1, but not Fas or TRAIL receptors, inhibits the cytopathicity and replication of human CMV by a nonapoptotic, reversible process that requires nuclear factor κB (NF-κB)-dependent induction of interferon-β (IFN-β). Efficient induction of IFN-β requires virus infection and LT signaling, demonstrating the need for both host and viral factors in the curtailment of viral replication without cellular elimination. LTα-deficient mice and LTβR-Fc transgenic mice were profoundly susceptible to murine CMV infection. Together, these results reveal an essential and conserved role for LTs in establishing host defense to CMV

A New Calibration Of Galactic Cepheid Period-Luminosity Relations From B To K Bands, And A Comparison To LMC Relations

Context. The universality of the Cepheid period-luminosity (PL) relations has been under discussion since metallicity effects were assumed to play a role in the value of the intercept and, more recently, of the slope of these relations. Aims. The goal of the present study is to calibrate the Galactic PL relations in various photometric bands (from B to K) and to compare the results to the well-established PL relations in the LMC. Methods. We use a set of 59 calibrating stars, the distances of which are measured using five different distance indicators: Hubble Space Telescope and revised Hipparcos parallaxes, infrared surface brightness and interferometric Baade-Wesselink parallaxes, and classical Zero-Age-Main-Sequence-fitting parallaxes for Cepheids belonging to open clusters or OB stars associations. A detailed discussion of absorption corrections and projection factor to be used is given. Results. We find no significant difference in the slopes of the PL relations between LMC and our Galaxy. Conclusions. We conclude that the Cepheid PL relations have universal slopes in all photometric bands, not depending on the galaxy under study (at least for LMC and Milky Way). The possible zero-point variation with metal content is not discussed in the present work, but an upper limit of 18.50 for the LMC distance modulus can be deduced from our data.McDonald Observator

Astrometric Methods and Instrumentation to Identify and Characterize Extrasolar Planets: A Review

I present a review of astrometric techniques and instrumentation utilized to search for, detect, and characterize extra-solar planets. First, I briefly summarize the properties of the present-day sample of extrasolar planets, in connection with predictions from theoretical models of planet formation and evolution. Next, the generic approach to planet detection with astrometry is described, with significant discussion of a variety of technical, statistical, and astrophysical issues to be faced by future ground-based as well as space-borne efforts in order to achieve the required degree of measurement precision. After a brief summary of past and present efforts to detect planets via milli-arcsecond astrometry, I then discuss the planet-finding capabilities of future astrometric observatories aiming at micro-arcsecond precision. Lastly, I outline a number experiments that can be conducted by means of high-precision astrometry during the next decade, to illustrate its potential for important contributions to planetary science, in comparison with other indirect and direct methods for the detection and characterization of planetary systems.Comment: 61 pages, 8 figures, PASP, accepted (October 2005 issue

Strategic Minimization of High Level Waste from Pyroprocessing of Spent Nuclear Fuel

The pyroprocessing of spent nuclear fuel results in two high-level waste streams--ceramic and metal waste. Ceramic waste contains active metal fission product-loaded salt from the electrorefining, while the metal waste contains cladding hulls and undissolved noble metals. While pyroprocessing was successfully demonstrated for treatment of spent fuel from Experimental Breeder Reactor-II in 1999, it was done so without a specific objective to minimize high-level waste generation. The ceramic waste process uses “throw-away” technology that is not optimized with respect to volume of waste generated. In looking past treatment of EBR-II fuel, it is critical to minimize waste generation for technology developed under the Global Nuclear Energy Partnership (GNEP). While the metal waste cannot be readily reduced, there are viable routes towards minimizing the ceramic waste. Fission products that generate high amounts of heat, such as Cs and Sr, can be separated from other active metal fission products and placed into short-term, shallow disposal. The remaining active metal fission products can be concentrated into the ceramic waste form using an ion exchange process. It has been estimated that ion exchange can reduce ceramic high-level waste quantities by as much as a factor of 3 relative to throw-away technology

Exchange and Correlation Kernels at the Resonance Frequency -- Implications for Excitation Energies in Density-Functional Theory

Specific matrix elements of exchange and correlation kernels in time-dependent density-functional theory are computed. The knowledge of these matrix elements not only constraints approximate time-dependent functionals, but also allows to link different practical approaches to excited states, either based on density-functional theory, or on many-body perturbation theory, despite the approximations that have been performed to derive them.Comment: Submitted to Phys. Rev. Lett. (February 4, 1999). Other related publications can be found at http://www.fhi-berlin.mpg.de/th/paper.htm

A Spitzer/IRAC Search for Substellar Companions of the Debris Disk Star epsilon Eridani

We have used the InfraRed Array Camera (IRAC) onboard the Spitzer Space telescope to search for low mass companions of the nearby debris disk star epsilon Eridani. The star was observed in two epochs 39 days apart, with different focal plane rotation to allow the subtraction of the instrumental Point Spread Function, achieving a maximum sensitivity of 0.01 MJy/sr at 3.6 and 4.5 um, and 0.05 MJy/sr at 5.8 and 8.0 um. This sensitivity is not sufficient to directly detect scattered or thermal radiation from the epsilon Eridani debris disk. It is however sufficient to allow the detection of Jovian planets with mass as low as 1 MJ in the IRAC 4.5 um band. In this band, we detected over 460 sources within the 5.70 arcmin field of view of our images. To test if any of these sources could be a low mass companion to epsilon Eridani, we have compared their colors and magnitudes with models and photometry of low mass objects. Of the sources detected in at least two IRAC bands, none fall into the range of mid-IR color and luminosity expected for cool, 1 Gyr substellar and planetary mass companions of epsilon Eridani, as determined by both models and observations of field M, L and T dwarf. We identify three new sources which have detections at 4.5 um only, the lower limit placed on their [3.6]-[4.5] color consistent with models of planetary mass objects. Their nature cannot be established with the currently available data and a new observation at a later epoch will be needed to measure their proper motion, in order to determine if they are physically associated to epsilon Eridani.Comment: 36 pages, to be published on The Astrophysical Journal, vol. 647, August 200

Islet neogenesis is stimulated by brief occlusion of the main pancreatic duct

Objective. Current models of islet neogenesis either cause substantial pancreatic damage or continuously stimulate the pancreas, making these models unsuitable for the study of early events that occur in the neogenic process. We aimed to develop a method where the initial events that culminate in increased pancreatic endocrine mass caube studied. Design and methods. Ten 12-week-old female Wistar rats were subjected to a midline laparotomy, the pancreas was isolated and the main pancreatic duct was occluded for 60 seconds. The pancreas was released and carefully relocated within the abdomen. Ten age-, strain- and sex-matched control rats were subjected to a sham operation. The animals were killed 56 days post .occlusion, and the pancreata excised and fiXed tor histological analysis. Body, pancreatic and hepatic weights were .noted at termination. and serum was taken for analysis. The endocrine-to-exocrine. ratio was calculated and the number of endocrine cells in eacn islet from the sectioned pancreata was counted. Results. Occlusion of the main pancreatic ductfor 60 seconds results in an increase in endocrine mass. by 80% 56 days post occlusion. This constitutes an increase in endocrine units (1 - 6 cellst and in small (7 - 30 cells), medium (31 - 60 cells) and large (> 60 cells) islets by 85%, 96%, 95% and 71% respectively. Conclusion. Brief occlusion of the main pancreatic duct results in anincrease in pancreatic endocrine. mass. An increase in endocrine units and small islets is indicative of islet neogenesis. Therefore, owing to the briefness of the stimulation; this model can therefore be used to study the iniUal events that occur during the neogenic process

A Model for the Voltage Steps in the Breakdown of the Integer Quantum Hall Effect

In samples used to maintain the US resistance standard the breakdown of the dissipationless integer quantum Hall effect occurs as a series of dissipative voltage steps. A mechanism for this type of breakdown is proposed, based on the generation of magneto-excitons when the quantum Hall fluid flows past an ionised impurity above a critical velocity. The calculated generation rate gives a voltage step height in good agreement with measurements on both electron and hole gases. We also compare this model to a hydrodynamic description of breakdown.Comment: 4 pages including 3 figure

Ab-initio prediction of the electronic and optical excitations in polythiophene: isolated chains versus bulk polymer

We calculate the electronic and optical excitations of polythiophene using the GW approximation for the electronic self-energy, and include excitonic effects by solving the electron-hole Bethe-Salpeter equation. Two different situations are studied: excitations on isolated chains and excitations on chains in crystalline polythiophene. The dielectric tensor for the crystalline situation is obtained by modeling the polymer chains as polarizable line objects, with a long-wavelength polarizability tensor obtained from the ab-initio polarizability function of the isolated chain. With this model dielectric tensor we construct a screened interaction for the crystalline case, including both intra- and interchain screening. In the crystalline situation both the quasi-particle band gap and the exciton binding energies are drastically reduced in comparison with the isolated chain. However, the optical gap is hardly affected. We expect this result to be relevant for conjugated polymers in general.Comment: 15 pages including 4 figures; to appear in Phys. Rev. B, 6/15/200