Towards an expanded model of litigation

Introduction: The call for contributions for this workshop describes the important new challenges for the legal search community this domain brings. Rather than just understanding the challenges this domain poses in terms of their technical properties, we would like to suggest that understanding these challenges as socio-technical challenges will be important. That is, as well as calling for research on a technical level to address these challenges we are also calling for work to understand the social practices of those involved in e-discovery (ED) and related legal work. A particularly interesting feature of this field is that it is likely that search technologies will (at least semi-)automate responsiveness review in the relatively near term and this will change the way that the work is organised and done in many ways – offering new possibilities for new ways of organising the work. As well as designing those technologies for automating responsiveness review we need to be envisioning how the work will be done in the future, how these technologies will impact the organisation of the case and so on. In this position paper we therefore outline the importance of understanding the wider social context of ED when designing tools and technologies to support and change the work. We would like to reinforce and expand on Conrad’s call for IR researchers to understand just what ED entails [2], include the stages that come both before and after core retrieval activities. The importance of considering the social aspects of work in the design of the technology has been established for some time. Ushering in this ‘turn to the social,’ and focusing on interface design, Gentner and Grudin [4] described how the GUI has already changed from an interface for engineers, representing the engineering model of the machine to one that supported single ‘everyman’ users (based on ideas from psychology). From then onwards the interface has evolved to support groups of users, taking into account the social and organisational contexts of use. This has particular resonance for the design of ED technologies: during ED in particular and the wider legal process there are often many lawyers involved – reviewing documents, determining issues, etc. Even if the way that their work is organised currently is not seen as collaborative in the traditional sense – with individual lawyers working on individual document sets to review them - their work needs to be coordinated and it seems likely that their work could be enhanced by, for example, knowledge of what their colleagues had found, how the case was shaping up, new key terms and facts turned up and so on. Work is often modelled for the purposes of design using process models, but this misses out on the richness and variety actually found when one examines how the work is carried out [3]. Technologies which strictly enforce the process models can often hinder the work, or end up being worked around as was the case with workflow systems since people interpret processes very flexibly to get the work done ([1], [3]). Other studies in other fields have found similar problems when systems are designed on for example cognitive models of how the work is done; they often do not take into account the situated nature of the work and thus they can be very difficult to use [5]. We believe, like [2], that a clear understanding of the social practices of ED is vital for the creation of high-quality, meaningful tools and technologies. We furthermore propose that work practice studies, to be used in combination with other methods, are a central part of getting the detailed understanding of the work practices central to designing useful and intelligent tools. Work practice studies would involve ethnographies, consisting primarily of observation, undertaken of practitioners engaging in the work of ED

Effects of supercoiling on enhancer-promoter contacts.

Using Brownian dynamics simulations, we investigate here one of possible roles of supercoiling within topological domains constituting interphase chromosomes of higher eukaryotes. We analysed how supercoiling affects the interaction between enhancers and promoters that are located in the same or in neighbouring topological domains. We show here that enhancer-promoter affinity and supercoiling act synergistically in increasing the fraction of time during which enhancer and promoter stay in contact. This stabilizing effect of supercoiling only acts on enhancers and promoters located in the same topological domain. We propose that the primary role of recently observed supercoiling of topological domains in interphase chromosomes of higher eukaryotes is to assure that enhancers contact almost exclusively their cognate promoters located in the same topological domain and avoid contacts with very similar promoters but located in neighbouring topological domains

Alexander quandle lower bounds for link genera

We denote by Q_F the family of the Alexander quandle structures supported by finite fields. For every k-component oriented link L, every partition P of L into h:=|P| sublinks, and every labelling z of such a partition by the natural numbers z_1,...,z_n, the number of X-colorings of any diagram of (L,z) is a well-defined invariant of (L,P), of the form q^(a_X(L,P,z)+1) for some natural number a_X(L,P,z). Letting X and z vary in Q_F and among the labellings of P, we define a derived invariant A_Q(L,P)=sup a_X(L,P,z). If P_M is such that |P_M|=k, we show that A_Q(L,P_M) is a lower bound for t(L), where t(L) is the tunnel number of L. If P is a "boundary partition" of L and g(L,P) denotes the infimum among the sums of the genera of a system of disjoint Seifert surfaces for the L_j's, then we show that A_Q(L,P) is at most 2g(L,P)+2k-|P|-1. We set A_Q(L):=A_Q(L,P_m), where |P_m|=1. By elaborating on a suitable version of a result by Inoue, we show that when L=K is a knot then A_Q(K) is bounded above by A(K), where A(K) is the breadth of the Alexander polynomial of K. However, for every g we exhibit examples of genus-g knots having the same Alexander polynomial but different quandle invariants A_Q. Moreover, in such examples A_Q provides sharp lower bounds for the genera of the knots. On the other hand, A_Q(L) can give better lower bounds on the genus than A(L), when L has at least two components. We show that in order to compute A_Q(L) it is enough to consider only colorings with respect to the constant labelling z=1. In the case when L=K is a knot, if either A_Q(K)=A(K) or A_Q(K) provides a sharp lower bound for the knot genus, or if A_Q(K)=1, then A_Q(K) can be realized by means of the proper subfamily of quandles X=(F_p,*), where p varies among the odd prime numbers.Comment: 36 pages; 16 figure

Spatial structures and dynamics of kinetically constrained models for glasses

Kob and Andersen's simple lattice models for the dynamics of structural glasses are analyzed. Although the particles have only hard core interactions, the imposed constraint that they cannot move if surrounded by too many others causes slow dynamics. On Bethe lattices a dynamical transition to a partially frozen phase occurs. In finite dimensions there exist rare mobile elements that destroy the transition. At low vacancy density, $v$, the spacing, $\Xi$, between mobile elements diverges exponentially or faster in $1/v$. Within the mobile elements, the dynamics is intrinsically cooperative and the characteristic time scale diverges faster than any power of $1/v$ (although slower than $\Xi$). The tagged-particle diffusion coefficient vanishes roughly as $\Xi^{-d}$.Comment: 4 pages. Accepted for pub. in Phys. Rev. Let

Studies of global and local entanglements of individual protein chains using the concept of knotoids.

We study here global and local entanglements of open protein chains by implementing the concept of knotoids. Knotoids have been introduced in 2012 by Vladimir Turaev as a generalization of knots in 3-dimensional space. More precisely, knotoids are diagrams representing projections of open curves in 3D space, in contrast to knot diagrams which represent projections of closed curves in 3D space. The intrinsic difference with classical knot theory is that the generalization provided by knotoids admits non-trivial topological entanglement of the open curves provided that their geometry is frozen as it is the case for crystallized proteins. Consequently, our approach doesn't require the closure of chains into loops which implies that the geometry of analysed chains does not need to be changed by closure in order to characterize their topology. Our study revealed that the knotoid approach detects protein regions that were classified earlier as knotted and also new, topologically interesting regions that we classify as pre-knotted

Lattice Glass Models

Motivated by the concept of geometrical frustration, we introduce a class of statistical mechanics lattice models for the glass transition. Monte Carlo simulations in three dimensions show that they display a dynamical glass transition which is very similar to that observed in other off-lattice systems and which does not depend on a specific dynamical rule. Whereas their analytic solution within the Bethe approximation shows that they do have a discontinuous glass transition compatible with the numerical observations.Comment: 4 pages, 2 figures; minor change

Transcription-induced supercoiling as the driving force of chromatin loop extrusion during formation of TADs in interphase chromosomes.

Using molecular dynamics simulations, we show here that growing plectonemes resulting from transcription-induced supercoiling have the ability to actively push cohesin rings along chromatin fibres. The pushing direction is such that within each topologically associating domain (TAD) cohesin rings forming handcuffs move from the source of supercoiling, constituted by RNA polymerase with associated DNA topoisomerase TOP1, towards borders of TADs, where supercoiling is released by topoisomerase TOPIIB. Cohesin handcuffs are pushed by continuous flux of supercoiling that is generated by transcription and is then progressively released by action of TOPIIB located at TADs borders. Our model explains what can be the driving force of chromatin loop extrusion and how it can be ensured that loops grow quickly and in a good direction. In addition, the supercoiling-driven loop extrusion mechanism is consistent with earlier explanations proposing why TADs flanked by convergent CTCF binding sites form more stable chromatin loops than TADs flanked by divergent CTCF binding sites. We discuss the role of supercoiling in stimulating enhancer promoter contacts and propose that transcription of eRNA sends the first wave of supercoiling that can activate mRNA transcription in a given TAD

Fractal space-times under the microscope: A Renormalization Group view on Monte Carlo data

The emergence of fractal features in the microscopic structure of space-time is a common theme in many approaches to quantum gravity. In this work we carry out a detailed renormalization group study of the spectral dimension $d_s$ and walk dimension $d_w$ associated with the effective space-times of asymptotically safe Quantum Einstein Gravity (QEG). We discover three scaling regimes where these generalized dimensions are approximately constant for an extended range of length scales: a classical regime where $d_s = d, d_w = 2$, a semi-classical regime where $d_s = 2d/(2+d), d_w = 2+d$, and the UV-fixed point regime where $d_s = d/2, d_w = 4$. On the length scales covered by three-dimensional Monte Carlo simulations, the resulting spectral dimension is shown to be in very good agreement with the data. This comparison also provides a natural explanation for the apparent puzzle between the short distance behavior of the spectral dimension reported from Causal Dynamical Triangulations (CDT), Euclidean Dynamical Triangulations (EDT), and Asymptotic Safety.Comment: 26 pages, 6 figure

(2+1)-Dimensional Quantum Gravity as the Continuum Limit of Causal Dynamical Triangulations

We perform a non-perturbative sum over geometries in a (2+1)-dimensional quantum gravity model given in terms of Causal Dynamical Triangulations. Inspired by the concept of triangulations of product type introduced previously, we impose an additional notion of order on the discrete, causal geometries. This simplifies the combinatorial problem of counting geometries just enough to enable us to calculate the transfer matrix between boundary states labelled by the area of the spatial universe, as well as the corresponding quantum Hamiltonian of the continuum theory. This is the first time in dimension larger than two that a Hamiltonian has been derived from such a model by mainly analytical means, and opens the way for a better understanding of scaling and renormalization issues.Comment: 38 pages, 13 figure

Tilings, tiling spaces and topology

To understand an aperiodic tiling (or a quasicrystal modeled on an aperiodic tiling), we construct a space of similar tilings, on which the group of translations acts naturally. This space is then an (abstract) dynamical system. Dynamical properties of the space (such as mixing, or the spectrum of the translation operator) are closely related to bulk properties of the individual tilings (such as the diffraction pattern). The topology of the space of tilings, particularly the Cech cohomology, gives information on how the original tiling can be deformed. Tiling spaces can be constructed as inverse limits of branched manifolds.Comment: 8 pages, including 2 figures, talk given at ICQ