860 research outputs found
Superdiffusivity of Finite-Range Asymmetric Exclusion Processes on
We consider finite-range asymmetric exclusion processes on with
non-zero drift. The diffusivity is expected to be of . We prove that in the weak (Tauberian) sense
that as . The proof employs the resolvent method to make a direct comparison with the
totally asymmetric simple exclusion process, for which the result is a
consequence of the scaling limit for the two-point function recently obtained
by Ferrari and Spohn. In the nearest neighbor case, we show further that
is monotone, and hence we can conclude that in the usual sense.Comment: Version 3. Statement of Theorem 3 is correcte
Founder effects facilitate the use of a genotyping-based approach to molecular diagnosis in Swedish patients with familial hypercholesterolaemia
Aim To investigate whether genotyping could be used as a cost-effective screening step, preceding next-generation sequencing (NGS), in molecular diagnosis of familial hypercholesterolaemia (FH) in Swedish patients. Methods and results Three hundred patients of Swedish origin with clinical suspicion of heterozygous FH were analysed using a specific array genotyping panel embedding 112 FH-causing mutations in the LDLR, APOB and PCSK9 genes. The mutations had been selected from previous reports on FH patients in Scandinavia and Finland. Mutation-negative cases were further analysed by NGS. In 181 patients with probable or definite FH using the Dutch lipid clinics network (DLCN) criteria (score >= 6), a causative mutation was identified in 116 (64%). Of these, 94 (81%) were detected by genotyping. Ten mutations accounted for more than 50% of the positive cases, with APOB c.10580G>A being the most common. Mutations in LDLR predominated, with (c.2311+1_2312-1)(2514)del (FH Helsinki) and c.259T>G having the highest frequency. Two novel LDLR mutations were identified. In patients with DLCN score A was higher than previously reported in Sweden. The lack of demonstrable mutations in the LDLR, APOB and PCSK9 genes in similar to 1/3 of patients with probable FH strongly suggests that additional genetic mechanisms are to be found in phenotypic FH.Peer reviewe
Space efficient opposed-anvil high-pressure cell and its application to optical and NMR measurements up to 9 GPa
We have developed a new type of opposed-anvil high pressure cell with
substantially improved space efficiency. The clamp cell and the gasket are made
of non-magnetic Ni-Cr-Al alloy. Non-magnetic tungsten carbide (NMWC) is used
for the anvils. The assembled cell with the dimension \phi 29mm \times 41mm is
capable of generating pressure up to 9 GPa over a relatively large volume of 7
mm3. Our cell is particularly suitable for those experiments which require
large sample space to achieve good signal-to-noise ratio, such as the nuclear
magnetic resonance (NMR) experiment. Argon is used as the pressure transmitting
medium to obtain good hydrostaticity. The pressure was calibrated in situ by
measuring the fluorescence from ruby through a transparent moissanite (6H-SiC)
window. We have measured the pressure and temperature dependences of the 63Cu
nuclear-quadrupole-resonance (NQR) frequency of Cu2O, the in-plane Knight shift
of metallic tin, and the Knight shift of platinum. These quantities can be used
as reliable manometers to determine the pressure values in situ during the
NMR/NQR experiments up to 9 GPa.Comment: 9 pages, 5 figures, 3 tables, accepted for publication in J. Phys.
Soc. Jp
The NeuroDante Project: Neurometric measurements of participantâs reaction to literary auditory stimuli from danteâs âdivina commediaâ
Neurodante. Progetto di analisi neurometrica di alcuni brani della Commedi
NEXUS/Physics: An interdisciplinary repurposing of physics for biologists
In response to increasing calls for the reform of the undergraduate science
curriculum for life science majors and pre-medical students (Bio2010,
Scientific Foundations for Future Physicians, Vision & Change), an
interdisciplinary team has created NEXUS/Physics: a repurposing of an
introductory physics curriculum for the life sciences. The curriculum interacts
strongly and supportively with introductory biology and chemistry courses taken
by life sciences students, with the goal of helping students build general,
multi-discipline scientific competencies. In order to do this, our two-semester
NEXUS/Physics course sequence is positioned as a second year course so students
will have had some exposure to basic concepts in biology and chemistry.
NEXUS/Physics stresses interdisciplinary examples and the content differs
markedly from traditional introductory physics to facilitate this. It extends
the discussion of energy to include interatomic potentials and chemical
reactions, the discussion of thermodynamics to include enthalpy and Gibbs free
energy, and includes a serious discussion of random vs. coherent motion
including diffusion. The development of instructional materials is coordinated
with careful education research. Both the new content and the results of the
research are described in a series of papers for which this paper serves as an
overview and context.Comment: 12 page
An ellipsoidal mirror for focusing neutral atomic and molecular beams
Manipulation of atomic and molecular beams is essential to atom optics applications including atom lasers, atom lithography, atom interferometry and neutral atom microscopy. The manipulation of charge-neutral beams of limited polarizability, spin or excitation states remains problematic, but may be overcome by the development of novel diffractive or reflective optical elements. In this paper, we present the first experimental demonstration of atom focusing using an ellipsoidal mirror. The ellipsoidal mirror enables stigmatic off-axis focusing for the first time and we demonstrate focusing of a beam of neutral, ground-state helium atoms down to an approximately circular spot, (26.8±0.5) ÎŒmĂ(31.4±0.8) ÎŒm in size. The spot area is two orders of magnitude smaller than previous reflective focusing of atomic beams and is a critical milestone towards the construction of a high-intensity scanning helium microscope
An ellipsoidal mirror for focusing neutral atomic and molecular beams
Manipulation of atomic and molecular beams is essential to atom optics applications including atom lasers, atom lithography, atom interferometry and neutral atom microscopy. The manipulation of charge-neutral beams of limited polarizability, spin or excitation states remains problematic, but may be overcome by the development of novel diffractive or reflective optical elements. In this paper, we present the first experimental demonstration of atom focusing using an ellipsoidal mirror. The ellipsoidal mirror enables stigmatic off-axis focusing for the first time and we demonstrate focusing of a beam of neutral, ground-state helium atoms down to an approximately circular spot, (26.8±0.5) ÎŒmĂ(31.4±0.8) ÎŒm in size. The spot area is two orders of magnitude smaller than previous reflective focusing of atomic beams and is a critical milestone towards the construction of a high-intensity scanning helium microscope
Stochastic pump effect and geometric phases in dissipative and stochastic systems
The success of Berry phases in quantum mechanics stimulated the study of
similar phenomena in other areas of physics, including the theory of living
cell locomotion and motion of patterns in nonlinear media. More recently,
geometric phases have been applied to systems operating in a strongly
stochastic environment, such as molecular motors. We discuss such geometric
effects in purely classical dissipative stochastic systems and their role in
the theory of the stochastic pump effect (SPE).Comment: Review. 35 pages. J. Phys. A: Math, Theor. (in press
Advances in ab-initio theory of Multiferroics. Materials and mechanisms: modelling and understanding
Within the broad class of multiferroics (compounds showing a coexistence of
magnetism and ferroelectricity), we focus on the subclass of "improper
electronic ferroelectrics", i.e. correlated materials where electronic degrees
of freedom (such as spin, charge or orbital) drive ferroelectricity. In
particular, in spin-induced ferroelectrics, there is not only a {\em
coexistence} of the two intriguing magnetic and dipolar orders; rather, there
is such an intimate link that one drives the other, suggesting a giant
magnetoelectric coupling. Via first-principles approaches based on density
functional theory, we review the microscopic mechanisms at the basis of
multiferroicity in several compounds, ranging from transition metal oxides to
organic multiferroics (MFs) to organic-inorganic hybrids (i.e. metal-organic
frameworks, MOFs)Comment: 22 pages, 9 figure
Dynamic light scattering study on phase separation of a protein-water mixture: Application on cold cataract development in the ocular lens
We present a detailed dynamic light scattering study on the phase separation
in the ocular lens emerging during cold cataract development. Cold cataract is
a phase separation effect that proceeds via spinodal decomposition of the lens
cytoplasm with cooling. Intensity auto-correlation functions of the lens
protein content are analyzed with the aid of two methods providing information
on the populations and dynamics of the scattering elements associated with cold
cataract. It is found that the temperature dependence of many measurable
parameters changes appreciably at the characteristic temperature ~16+1 oC which
is associated with the onset of cold cataract. Extending the temperature range
of this work to previously inaccessible regimes, i.e. well below the phase
separation or coexistence curve at Tcc, we have been able to accurately
determine the temperature dependence of the collective and self-diffusion
coefficient of proteins near the spinodal. The analysis showed that the
dynamics of proteins bears some resemblance to the dynamics of structural
glasses where the apparent activation energy for particle diffusion increases
below Tcc indicating a highly cooperative motion. Application of ideas
developed for studying the critical dynamics of binary protein/solvent
mixtures, as well as the use of a modified Arrhenius equation, enabled us to
estimate the spinodal temperature Tsp of the lens nucleus. The applicability of
dynamic light scattering as a non-invasive, early-diagnostic tool for ocular
diseases is also demonstrated in the light of the findings of the present
paper
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