10 research outputs found
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Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.
The goals of Epilepsy Benchmark Area III involve identifying areas that are ripe for progress in terms of controlling seizures and patient symptoms in light of the most recent advances in both basic and clinical research. These goals were developed with an emphasis on potential new therapeutic strategies that will reduce seizure burden and improve quality of life for patients with epilepsy. In particular, we continue to support the proposition that a better understanding of how seizures are initiated, propagated, and terminated in different forms of epilepsy is central to enabling new approaches to treatment, including pharmacological as well as surgical and device-oriented approaches. The stubbornly high rate of treatment-resistant epilepsy-one-third of patients-emphasizes the urgent need for new therapeutic strategies, including pharmacological, procedural, device linked, and genetic. The development of new approaches can be advanced by better animal models of seizure initiation that represent salient features of human epilepsy, as well as humanized models such as induced pluripotent stem cells and organoids. The rapid advances in genetic understanding of a subset of epilepsies provide a path to new and direct patient-relevant cellular and animal models, which could catalyze conceptualization of new treatments that may be broadly applicable across multiple forms of epilepsies beyond those arising from variation in a single gene. Remarkable advances in machine learning algorithms and miniaturization of devices and increases in computational power together provide an enhanced opportunity to detect and mitigate seizures in real time via devices that interrupt electrical activity directly or administer effective pharmaceuticals. Each of these potential areas for advance will be discussed in turn
The 1985 survey of materials Summary report; a research project conducted for Eureka Magazine
SIGLEAvailable from British Library Document Supply Centre- DSC:87/00667(1985) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
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Evaluation of environmentally safe cleaning agents for diamond turned optics
Precision machining of metal surfaces using diamond turning has increased greatly in popularity at LANL in recent years. Similar techniques are used extensively to manufacture metal mirrors for use in laser applications. The diamond turned surfaces are easily damaged, making the selection of a cleaning agent very critical. These surfaces have been traditionally cleaned using Trichloroethane (TCA) to remove residual oil remaining from the machining process. The TCA was then removed with an ethanol rinse, leaving a residue free surface. Recently, however, TCA was pronounced environmentally unsafe. Consequently, we are searching for an environmentally safe cleaning agent for these diamond turned metal optics. The concern with using alternative solvents is the potential for residual surface films that produce reflectivity changes related to a combination of wavelength, surface coverage, film thickness and dielectric properties. Therefore, we have initiated a program for testing the effectiveness of a variety of environmentally safe solvents used to clean diamond turned optical surfaces. Our basic test plan consists of comparing a number of environmentally safe solvents against the TCA/ethanol cleaning system. We have identified twelve candidate solvents, but have only been able to perform a partial test on one of them to date. This paper discusses the results obtained to data using this solvent known as P F (1). 3 refs., 13 figs
Uncertainty Analysis of Neutron Diffusion Eigenvalue Problem Based on Reduced-order Model
In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model based on POD-Galerkin method in core physical uncertainty analysis. The two-dimensional two group TWIGL benchmark question was taken as the research object, the key variation characteristics of the core flux distribution were extracted under the finite perturbation of the group constants of each material region, and the full-order neutron diffusion problem was projected on the variation characteristics to establish a reduced-order neutron diffusion model. The reduced-order model was used to replace the full-order model to carry out the uncertainty analysis of the group constants of the material region. The results show that the bias of the mathematical expectation of keff calculated by reduced-order and full-order models is close to 1 pcm. In addition, compared with the calculation time required for uncertainty analysis of full-order model, the analysis time of reduced-order model (including the calculation time of the full-order model required for the construction of reduced-order model) is only 11.48%, which greatly improves the efficiency of uncertainty analysis. The biases of mathematical expectation of keff calculated by reduced-order and full-order models based on Latin hypercube sampling and simple random sampling are less than 8 pcm, and under the same sample size, the bias from the Latin hypercube sampling result is smaller. From the TWIGL benchmark test results, under the same sample size, Latin hypercube sampling method is more recommended for POD-Galerkin reduced-order model