58 research outputs found
Testing A (Stringy) Model of Quantum Gravity
I discuss a specific model of space-time foam, inspired by the modern
non-perturbative approach to string theory (D-branes). The model views our
world as a three brane, intersecting with D-particles that represent stringy
quantum gravity effects, which can be real or virtual. In this picture, matter
is represented generically by (closed or open) strings on the D3 brane
propagating in such a background. Scattering of the (matter) strings off the
D-particles causes recoil of the latter, which in turn results in a distortion
of the surrounding space-time fluid and the formation of (microscopic, i.e.
Planckian size) horizons around the defects. As a mean-field result, the
dispersion relation of the various particle excitations is modified, leading to
non-trivial optical properties of the space time, for instance a non-trivial
refractive index for the case of photons or other massless probes. Such models
make falsifiable predictions, that may be tested experimentally in the
foreseeable future. I describe a few such tests, ranging from observations of
light from distant gamma-ray-bursters and ultra high energy cosmic rays, to
tests using gravity-wave interferometric devices and terrestrial particle
physics experients involving, for instance, neutral kaons.Comment: 25 pages LATEX, four figures incorporated, uses special proceedings
style. Invited talk at the third international conference on Dark Matter in
Astro and Particle Physics, DARK2000, Heidelberg, Germany, July 10-15 200
Fatty Acid and Peptide Profiles in Plasma Membrane and Membrane Rafts of PUFA Supplemented RAW264.7 Macrophages
The eukaryotic cell membrane possesses numerous complex functions, which are essential for life. At this, the composition and the structure of the lipid bilayer are of particular importance. Polyunsaturated fatty acids may modulate the physical properties of biological membranes via alteration of membrane lipid composition affecting numerous physiological processes, e.g. in the immune system. In this systematic study we present fatty acid and peptide profiles of cell membrane and membrane rafts of murine macrophages that have been supplemented with saturated fatty acids as well as PUFAs from the n-3, the n-6 and the n-9 family. Using fatty acid composition analysis and mass spectrometry-based peptidome profiling we found that PUFAs from both the n-3 and the n-6 family have an impact on lipid and protein composition of plasma membrane and membrane rafts in a similar manner. In addition, we found a relation between the number of bis-allyl-methylene positions of the PUFA added and the unsaturation index of plasma membrane as well as membrane rafts of supplemented cells. With regard to the proposed significance of lipid microdomains for disease development and treatment our study will help to achieve a targeted dietary modulation of immune cell lipid bilayers
Quantum Spacetime Phenomenology
I review the current status of phenomenological programs inspired by
quantum-spacetime research. I stress in particular the significance of results
establishing that certain data analyses provide sensitivity to effects
introduced genuinely at the Planck scale. And my main focus is on
phenomenological programs that managed to affect the directions taken by
studies of quantum-spacetime theories.Comment: 125 pages, LaTex. This V2 is updated and more detailed than the V1,
particularly for quantum-spacetime phenomenology. The main text of this V2 is
about 25% more than the main text of the V1. Reference list roughly double
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