1,531 research outputs found
Examens périodiques de santé effectués chez des personnes en situation de handicap en Normandie durant l’année 2012
Adding a quadrivalent human papillomavirus vaccine to the UK cervical cancer screening programme: A cost-effectiveness analysis
<p>Abstract</p> <p>Background</p> <p>We assessed the cost-effectiveness of adding a quadrivalent (6/11/16/18) human papillomavirus (HPV) vaccine to the current screening programme in the UK compared to screening alone.</p> <p>Methods</p> <p>A Markov model of the natural history of HPV infection incorporating screening and vaccination was developed. A vaccine that prevents 98% of HPV 6, 11, 16 and 18-associated disease, with a lifetime duration and 85% coverage, in conjunction with current screening was considered.</p> <p>Results</p> <p>Vaccination with screening, compared to screening alone, was associated with an incremental cost-effectiveness ratio of £21,059 per quality adjusted life year (QALY) and £34,687 per life year saved (LYS). More than 400 cases of cervical cancer, 6700 cases of cervical intraepithelial neoplasia and 4750 cases of genital warts could be avoided per 100,000 vaccinated girls. Results were sensitive to assumptions about the need for a booster, the duration of vaccine efficacy and discount rate.</p> <p>Conclusion</p> <p>These analyses suggest that adding a quadrivalent HPV vaccine to current screening in the UK could be a cost-effective method for further reducing the burden of cervical cancer.</p
Synthesis of bioactive 2-(arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff reaction or Cu- catalyzed intramolecular C-S bond formation
International audienceA library of thirty eight novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives (series 8, 10, 14 and 17) was prepared via the Hügershoff reaction and a Cu catalyzed intramolecular C-S bond formation, helped by microwave-assisted technology when required. The efficient multistep synthesis of the key 6-amino-3-cyclopropylquinazolin-4(3H)-one (3) has been reinvestigated and performed on a multigram scale from the starting 5-nitroanthranilic acid. The inhibitory potency of the final products was evaluated against five kinases involved in Alzheimer’s disease and showed that some molecules of the 17 series described in this paper are particularly promising for the development of novel multi-target inhibitors of kinases
Renormalization group approach of itinerant electron systems near the Lifshitz point
Using the renormalization approach proposed by Millis for the itinerant
electron systems we calculated the specific heat coefficient for
the magnetic fluctuations with susceptibility near the Lifshitz point. The constant value
obtained for and the logarithmic temperature dependence, specific
for the non-Fermi behavior, have been obtained in agreement with the
experimental dat.Comment: 6 pages, Revte
Modelling as an evaluation tool for the relative contribution of the anthropic discharges to the Seine quality, downstream the Paris area
Liquid Xenon Detectors for Positron Emission Tomography
PET is a functional imaging technique based on detection of annihilation
photons following beta decay producing positrons. In this paper, we present the
concept of a new PET system for preclinical applications consisting of a ring
of twelve time projection chambers filled with liquid xenon viewed by avalanche
photodiodes. Simultaneous measurement of ionization charge and scintillation
light leads to a significant improvement to spatial resolution, image quality,
and sensitivity. Simulated performance shows that an energy resolution of <10%
(FWHM) and a sensitivity of 15% are achievable. First tests with a prototype
TPC indicate position resolution <1 mm (FWHM).Comment: Paper presented at the International Nuclear Physics Conference,
Vancouver, Canada, 201
Dynamics of Transformation from Segregation to Mixed Wealth Cities
We model the dynamics of the Schelling model for agents described simply by a
continuously distributed variable - wealth. Agents move to neighborhoods where
their wealth is not lesser than that of some proportion of their neighbors, the
threshold level. As in the case of the classic Schelling model where
segregation obtains between two races, we find here that wealth-based
segregation occurs and persists. However, introducing uncertainty into the
decision to move - that is, with some probability, if agents are allowed to
move even though the threshold level condition is contravened - we find that
even for small proportions of such disallowed moves, the dynamics no longer
yield segregation but instead sharply transition into a persistent mixed wealth
distribution. We investigate the nature of this sharp transformation between
segregated and mixed states, and find that it is because of a non-linear
relationship between allowed moves and disallowed moves. For small increases in
disallowed moves, there is a rapid corresponding increase in allowed moves, but
this tapers off as the fraction of disallowed moves increase further and
finally settles at a stable value, remaining invariant to any further increase
in disallowed moves. It is the overall effect of the dynamics in the initial
region (with small numbers of disallowed moves) that shifts the system away
from a state of segregation rapidly to a mixed wealth state.
The contravention of the tolerance condition could be interpreted as public
policy interventions like minimal levels of social housing or housing benefit
transfers to poorer households. Our finding therefore suggests that it might
require only very limited levels of such public intervention - just sufficient
to enable a small fraction of disallowed moves, because the dynamics generated
by such moves could spur the transformation from a segregated to mixed
equilibrium.Comment: 12 pages, 7 figure
- …