6,104 research outputs found
Stability over a finite time interval
This thesis will be concerned with the study of the new concept of
final-stability which is a direct generalisation of the theory of
stability over a finite time interval.
The introduction deals with an intuitive historical development which
leads to the concept under consideration.
The main part, chapters I and II, is devoted to the study of differential
systems. Precise definitions of the concept are stated, and a corresponding
theory is established. Use has been extensively made of
Liapunov-like functions. The possible relationship with the theory of
controllability is indicated.
Dynamical and discrete systems are then studied in some detail. For
dynamical systems, a somewhat different approach is considered.
Finally, possible future topics of research are suggested and discussed
Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryotes there is a vast array of Hsp70 isoforms that may facilitate adaption to a particular cellular compartment and distinct biological role. Emerging data indicate a novel type of interaction between Hsp70 and client protein that does not fit with the classical Hsp70 ATP regulated substrate mechanism. In this review, we highlight Hsp70 ATPase domain interactions with binding partners from various biological systems that we refer to as Hsp70 ATPase alternative binding proteins or HAAB proteins. We identify common mechanistic features that may define how Hsp70 operates when associating with proteins in this alternative HAAB mode of action
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