8 research outputs found
Alkylation of Spiropyran Moiety Provides Reversible Photo-Control over Nanostructured Soft Materials
Generation of Geometrically Ordered Lipid-Based Liquid-Crystalline Nanoparticles Using Biologically Relevant Enzymatic Processing
High-symmetry
lipid nanoparticles with internal bicontinuous cubic
phase structure (cubosomes) are prepared from a simple emulsion containing
a mixture of a nondigestible lipid (phytantriol) and a digestible
short-chained triglyceride using enzymatic lipolysis of the incorporated
short-chained triglyceride. The lipolytic products partition away
from the nondigestible lipid, resulting in crystallization of the
cubic-phase internal structure. Time-resolved small-angle X-ray scattering
revealed the kinetics of the disorder-to-order transition, with cryo-transmission
electron microscopy showing an absence of liposomes. The new approach
offers a new “sideways” method for the generation of
lipid-based nanostructured materials that avoids the problems of top-down
and bottom-up approaches
Generation of Geometrically Ordered Lipid-Based Liquid-Crystalline Nanoparticles Using Biologically Relevant Enzymatic Processing
High-symmetry
lipid nanoparticles with internal bicontinuous cubic
phase structure (cubosomes) are prepared from a simple emulsion containing
a mixture of a nondigestible lipid (phytantriol) and a digestible
short-chained triglyceride using enzymatic lipolysis of the incorporated
short-chained triglyceride. The lipolytic products partition away
from the nondigestible lipid, resulting in crystallization of the
cubic-phase internal structure. Time-resolved small-angle X-ray scattering
revealed the kinetics of the disorder-to-order transition, with cryo-transmission
electron microscopy showing an absence of liposomes. The new approach
offers a new “sideways” method for the generation of
lipid-based nanostructured materials that avoids the problems of top-down
and bottom-up approaches