Ionic organic-inorganic (C6H10N2) (Hg2Cl5)2·3H2O compound Structural study, hirshfeld surface, thermal behavior and spectroscopic studies

International audienceA novel organic-inorganic hybrid material (C6H10N2)(Hg2Cl5)2·3H2O has been prepared under hydrothermal conditions. It is characterized by single crystal X-ray diffraction, thermal analysis and spectroscopy measurements (IR, Raman and NMR). The structural analysis revealed that this material crystallizes in the monoclinic system (C 2/c space group) with the following unit cell parameters a = 19.6830(15) Å b = 18.1870(15) Å c = 6.8567(6) Å β = 93.224(3) ° and Z = 4. According to the data collected at 150(2) K, the refinement converged to R = 0.0296. The atomic arrangement can be described as an alternation of cationic [C6H10N2]2+.H2O and anionic [Hg2Cl5]- layers along the c axis. In fact, a three-dimensional cohesion, which leads to these peridinium complexes, involves (N–H***Cl) (N–H***O) (O–H***O) and π–π interactions. Furthermore the FT-IR, Raman and NMR-MAS confirm the presence of organic and inorganic entities. Finally, the differential scanning calorimetry revealed several endothermic peaks

Polyphenols bioaccessibility and bioavailability assessment in ipecac infusion using a combined assay of simulated in vitro digestion and Caco-2 cell model

In this report, we investigated for the first time the total polyphenols content (TPC) and antioxidant activity before and after digestion of Carapichea ipecacuanha root infusion, better known as ipecac, prepared at different concentrations. An in vitro digestion system coupled to a Caco-2 cell model was applied to study the bioavailability of antioxidant compounds. The ability of ipecac bioaccessible fractions to inhibit reactive oxygen species (ROS) generation at cellular level was also evaluated. The findings revealed that water volume of 50 mL g-1 of sample provided the maximum yield of extraction of TPC and antioxidant activity. Polyphenols increased in content and activity after digestion and they were highly bioavailable (75% of intestinal absorption). Polyphenols were also present in the residual parts which indicate a possible local activity. Results also suggest that ipecac infusion could represent a promising source of effective bioavailable antioxidants to be exploited in functional foods field.This study was supported by the financial project of LIP‐MB laboratory LR11ES24 of INSAT, University of Carthage and by the University of Tunis El Manar, Ministry of Higher Education and Scientific Research of Tunisia through the scholarship support provided to the first author. We are grateful to Dr. Chokri Messaoud for the identification of the plant.Peer Reviewe