Stability over a finite time interval

This thesis will be concerned with the study of the new concept of final-stability which is a direct generalisation of the theory of stability over a finite time interval. The introduction deals with an intuitive historical development which leads to the concept under consideration. The main part, chapters I and II, is devoted to the study of differential systems. Precise definitions of the concept are stated, and a corresponding theory is established. Use has been extensively made of Liapunov-like functions. The possible relationship with the theory of controllability is indicated. Dynamical and discrete systems are then studied in some detail. For dynamical systems, a somewhat different approach is considered. Finally, possible future topics of research are suggested and discussed

Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones

Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryotes there is a vast array of Hsp70 isoforms that may facilitate adaption to a particular cellular compartment and distinct biological role. Emerging data indicate a novel type of interaction between Hsp70 and client protein that does not fit with the classical Hsp70 ATP regulated substrate mechanism. In this review, we highlight Hsp70 ATPase domain interactions with binding partners from various biological systems that we refer to as Hsp70 ATPase alternative binding proteins or HAAB proteins. We identify common mechanistic features that may define how Hsp70 operates when associating with proteins in this alternative HAAB mode of action