12 research outputs found
The xanthine content of guarana and its preparations
The Identity Of Caffeine As The Major Xanthine Present In Guarana Has Been Confirmed By Spectroscopic Methods. Theobromine and Theophylline Were Present In Small Amounts But The Presence Of A Tetramethylxanthine Could Not Be Detected. Evidence Was Obtained For The Presence Of A Complex Of Caffeine and A Tannin. Hplc Was Used To Quantify The Caffeine Present In Various Samples Of Guarana and Its Products. The Amount Of Caffeine Present Was Found To Be Between 2.0 and 4.5% W/W Which Is Of The Same Order As That Present In Tea and Coffee
Spectrophotometric determination of tannins and caffeine in preparations from Paullinia cupana var. sorbilis
Dissolution test of herbal medicines containing Paullinia cupana: validation of methods for quantification and assessment of dissolution
"Guaraná" (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin), while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes, only capsule A showed at least 80% of the dissolved markers. In other capsules, marker dissolution did not exceed 60% whereas 60% of the samples had some characteristic pharmacotechnical problems. These results evidence the need for rigorous quality control to help ensure the therapeutic action of these drugs. To this end, dissolution studies are an essential tool for quality assurance of herbal medicines.<br>Guaraná (Paullinia cupana) Ă© utilizado como revigorante e estimulante devido Ă presença de metilxantinas e taninos condensados. Este trabalho visou avaliar o comportamento de dissolução de cinco fitoterápicos, na forma de cápsulas e comprimidos, contendo guaraná. O mĂ©todo de quantificação e de dissolução foram validados e os resultados obtidos permitiram a quantificação dos marcadores simultaneamente, com precisĂŁo, exatidĂŁo, seletividade e robustez. Foi verificado que 100% dos fitoterápicos analisados encontravam em desacordo quanto Ă presença dos quatro marcadores, sendo que 60% apresentaram trĂŞs marcadores (cafeĂna, catequina e epicatequina) e 40% apresentaram somente a cafeĂna. AlĂ©m disso, apĂłs o tempo de 30 minutos de ensaio foi possĂvel observar que somente a cápsula A apresentou pelo menos 80% dos marcadores dissolvidos. Nas demais cápsulas o comportamento de dissolução apresentado pelos marcadores nĂŁo ultrapassou 60% e, alĂ©m disso, 60% das amostras apresentaram alguns problemas farmacotĂ©cnicos caracterĂsticos. Frente aos resultados obtidos torna-se evidente a necessidade de um rigoroso controle de qualidade que contribua para assegurar a ação terapĂŞutica desses medicamentos e, nesse sentido, o estudo de dissolução constitui uma ferramenta essencial para a garantia de qualidade dos fitoterápicos