7,854 research outputs found
The human story behind Everettian quantum mechanics
Hugh Everett III was an unappealing character with a remarkable mind. His Princeton doctoral thesis on the foundations of physics transformed our understanding of quantum-mechanical reality, and he made original contributions to military operations research and to game theory. His domestic life was less inspiring; he died young after a lifetime of over-indulgence in food, alcohol, tobacco and sex, leaving behind a somewhat dysfunctional family with which he had little emotional connection
A representation of a compressed de Bruijn graph for pan-genome analysis that enables search
Recently, Marcus et al. (Bioinformatics 2014) proposed to use a compressed de
Bruijn graph to describe the relationship between the genomes of many
individuals/strains of the same or closely related species. They devised an
time algorithm called splitMEM that constructs this graph
directly (i.e., without using the uncompressed de Bruijn graph) based on a
suffix tree, where is the total length of the genomes and is the length
of the longest genome. In this paper, we present a construction algorithm that
outperforms their algorithm in theory and in practice. Moreover, we propose a
new space-efficient representation of the compressed de Bruijn graph that adds
the possibility to search for a pattern (e.g. an allele - a variant form of a
gene) within the pan-genome.Comment: Submitted to Algorithmica special issue of CPM201
Fast, Scalable, and Interactive Software for Landau-de Gennes Numerical Modeling of Nematic Topological Defects
Numerical modeling of nematic liquid crystals using the tensorial Landau-de
Gennes (LdG) theory provides detailed insights into the structure and
energetics of the enormous variety of possible topological defect
configurations that may arise when the liquid crystal is in contact with
colloidal inclusions or structured boundaries. However, these methods can be
computationally expensive, making it challenging to predict (meta)stable
configurations involving several colloidal particles, and they are often
restricted to system sizes well below the experimental scale. Here we present
an open-source software package that exploits the embarrassingly parallel
structure of the lattice discretization of the LdG approach. Our
implementation, combining CUDA/C++ and OpenMPI, allows users to accelerate
simulations using both CPU and GPU resources in either single- or multiple-core
configurations. We make use of an efficient minimization algorithm, the Fast
Inertial Relaxation Engine (FIRE) method, that is well-suited to large-scale
parallelization, requiring little additional memory or computational cost while
offering performance competitive with other commonly used methods. In
multi-core operation we are able to scale simulations up to supra-micron length
scales of experimental relevance, and in single-core operation the simulation
package includes a user-friendly GUI environment for rapid prototyping of
interfacial features and the multifarious defect states they can promote. To
demonstrate this software package, we examine in detail the competition between
curvilinear disclinations and point-like hedgehog defects as size scale,
material properties, and geometric features are varied. We also study the
effects of an interface patterned with an array of topological point-defects.Comment: 16 pages, 6 figures, 1 youtube link. The full catastroph
The RSBH value-judgment inventory:preliminary analysis of the Portuguese version
The belief that sports build character has been held across the centuries. However, the scientific scrutiny of these beliefs is only a few decades old. The RSBH Value-judgment Inventory (RSBH VI; Rudd, Stoll, Beller, & Hahm, 1996) was developed to assess moral (α = .82-.88) and social (α = .70-.77) reasoning. The former is based the principles of honesty, responsibility, and justice. By applying the defined principles, any abused or confused situation should be solved within moral standards (see Lumpkin, Stoll & Beller, 2003). The latter is about weighing a social value against a moral value which is more important. The purpose of this study is to validate the Portuguese version of RSBH Value-judgment Inventory (RSBH VI-P). To investigate for construct validity, it was anticipated that moral reasoning would be negatively associated with ego-involvement, but positively associated with task-involvement
Looks Can Be Deceiving—A Comparison of Initial Public Offering Procedures Under Japanese and U.S. Securities Laws
In order to examine the divergent administration of statutes that are by their terms similar, the initial public offering procedures that a non-sovereign domestic issuer follows in the US and Japan are described
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