The role of fluctuating soundscapes in shaping the emotional geographies of individuals living with Ménière’s disease

This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this record.The potential for everyday soundscapes to evoke diverse emotions amongst different cultural and acoustic communities is increasingly recognised within the literature. However, few studies have examined how these soundscapes can shift with the onset and progression of specific hearing impairments. This paper explores such shifts, drawing on a series of in-depth narrative interviews conducted in the south west of England with individuals diagnosed with Ménière’s disease; a long-term progressive vestibular disorder characterised by episodes of vertigo, tinnitus, sensorineural hearing loss and, for some people, hyperacusis (high sensitivity to sudden irregular sounds). Located in the subfield of ‘emotional geographies’, the paper discusses how participants were forced to connect with and attune to previously unremarkable aspects of their everyday soundscapes in ways that were both emotionally and socially challenging. Four aspects of participants’ embodied, emotional soundscapes are critically explored: hearing life in ‘2D’; corporeal and environmental ‘sonic intruders’; corporeal sound ‘symbols’; and seeking to regain a semblance of control through soundscape (re)-negotiations. Such insights are important to inform conscious acoustic design efforts that respect the ‘ears and voice’ of people living with varying levels of auditory sensitivity, rather than urban and community planning policies that continue to prioritise vision and transit.This work was supported by the Ménière’s Society with further follow-on funding provided by PenCLAHRC (no grant numbers given)

Experiencing nature with sight impairment: seeking freedom from ableism

This is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this record.Data Accessibility: Due to ethical concerns of maintaining participant confidentiality, the research data supporting this publication are not publicly available.The idea of nature as freedom has long captured the human imagination, particularly since the Romantic era when notions of escapism were underpinned by the idealisation and externalisation of nature. The drive for freedom persists in the findings of much contemporary research examining the contribution of nature to human health and wellbeing. Yet, this work tells us little about how cultural narratives of freedom play out in the lives of people living with impairment and disability, or the constraining ableist assumptions that often underpin popular discourses of nature. This paper aims to address this, drawing on the findings of an in-­‐depth qualitative study exploring how 31 people with varying forms and severities of sight impairment, living in rural and urban areas of England, describe their experiences with(in) diverse types of nature through the life course. Moving beyond the ‘wilderness ideal’ and sensationalised ‘supercrip’ stories that reproduce ableist ideas of bodies without limitation, this paper foregrounds the richly textured ways in which participants experienced feelings of freedom with nonhuman nature. These freedoms are characterised as social, mobile and exploratory. In doing so, it seeks to make room for a range of nature experiences, folding social justice into the growing momentum to connect people with nature in the name of health and wellbeing.Economic and Social Research Council (ESRC

Beyond “Move More”: Feeling the Rhythms of physical activity in mid and later-life

This is the author accepted manuscriptThe last two decades have seen growing unease regarding the negative health consequences of increasing levels of physical inactivity, both in the UK and further afield. Public health initiatives and interventions aimed at increasing levels of physical activity have, therefore, become somewhat commonplace. Within the current context of demographic change, with growing numbers of older adults and evidence that inactivity increases with age, these initiatives hold particular relevance to mid and later-life adults. Yet despite their prevalence, the policy gains from such promotional efforts have typically been modest at best, demonstrating the limits to decontextualized health messages that encourage people to ‘sit less’, ‘move more’ or ‘move faster’. In this paper, we draw on the concept of rhythm, to provide an original contribution in response to recent calls to rethink existing approaches to physical activity in mid-life and beyond. We draw from three qualitative data sets from separate studies exploring health, wellbeing and ageing (two in the context of chronic health conditions and sensory impairments). Inspired by facet methodology, we advance knowledge by providing ‘flashes of insight’ into the subtle patterns and tempos that frame physical activity in mid and later life. In doing so, we offer alternative insight into how people avail themselves to, and experience motion and stillness during these life stages. That alternative, as we also note, has an important role to play in the development of appropriate, relatable health messages regarding movement that recognises ‘expertise by experience’.This work was supported by funding from the Economic and SocialResearch Council (RES-061-30-000551), the Thomas Pocklington Trustand the Ménière's Society

Segregation and the Sea: Towards a Critical Understanding of Race and Coastal Blue Space in Greater Miami

This is the final version. Available on open access from SAGE Publications via the DOI in this recordThere is a growing body of research signalling the health and wellbeing benefits of being in blue space. Here, we advance this intellectual agenda by critically examining perceptions and experiences of coastal blue space among residents of a disadvantaged, predominantly African-American community who report limited engagement with their local coastal blue space, despite beachgoing being considered mainstream by a previous generation. Drawing on focus group data and sensitised to a range of theoretical perspectives aligned with race, space and social class, we advance theoretical and empirical knowledge pertaining to blue space engagement. In doing so, we demonstrate the need for more critically informed, theoretically appropriate research in this area, which connects individual stories of the sea to the wider historical, social and political settings in which relationships with blue space are framed and produced.University of ExeterEuropean Regional Development Fund Programme 2007-2013European Social Fund Convergence Programme for Cornwall and the Isles of ScillyNational Science Foundation (NSF)National Institute of Environmental Health Sciences (NIEHS) Oceans and Human Health Center, University of Miami Rosenstiel Schoo

Using geonarratives to explore the diverse temporalities of therapeutic landscapes: perspectives from ‘green’ and ‘blue’ settings

This is the author accepted manuscript. The final version is available from Taylor and Francis via the DOI in this record.A growing evidence base highlights “green” and “blue” spaces as examples of “therapeutic landscapes” incorporated into people’s lives to maintain a sense of wellbeing. A commonly overlooked dimension within this corpus of work concerns the dynamic nature of people’s therapeutic place assemblages over time. This article provides these novel temporal perspectives, drawing on the findings of an innovative three-stage interpretive geo-narrative study conducted in south-west England from May to November 2013, designed to explore the complex spatial-temporal ordering of people’s lives. Activity maps produced using accelerometer and Global Positioning system (GPS) data were used to guide in-depth geonarrative interviews with 33 participants, followed by a subset of go-along interviews in therapeutic places deemed important by participants. Concepts of “fleeting time”, “restorative time” and “biographical time” are used, alongside notions of individual agency, to examine participants’ green and blue space experiences in the context of the temporal structures characterising their everyday lives and the biographical experiences contributing to the perceived importance of such settings over time. In a culture that by and large prioritises speed, dominated by social ideals of, for example, the “productive worker” and the “good parent”, participants conveyed a desire to shift from “fleeting time” to “restorative time”, seeking a balance between embodied stillness and therapeutic mobility. This was deemed particularly important during more stressful life transitions, such as parenthood, employment shifts and the onset of illness or impairment, when participants worked hard to tailor their therapeutic geographies to shifting wellbeing needs and priorities.This work was supported by the European Social Fund Convergence Programme for Cornwall and the Isles of Scilly

Gaussian Processes for hearing threshold estimation using Auditory Brainstem Responses

The Auditory Brainstem Response (ABR) plays an important role in diagnosing and managing hearing loss, but can be challenging and time-consuming to measure. Test times are especially long when multiple ABR measurements are needed, e.g., when estimating hearing threshold at a range of frequencies. While many detection methods have been developed to reduce ABR test times, the majority were designed to detect the ABR at a single stimulus level and do not consider correlations in ABR waveforms across levels. These correlations hold valuable information, and can be exploited for more efficient hearing threshold estimation. This was achieved in the current work using a Gaussian Process (GP), i.e., a Bayesian approach method for non-linear regression. The function to estimate with the GP was the ABR's amplitude across stimulus levels, from which hearing threshold was ultimately inferred. Active learning rules were also designed to automatically adjust the stimulus level and efficiently locate hearing threshold. Simulation results show test time reductions of up to $\sim$50% for the GP compared to a sequentially applied Hotelling's T2 test, which does not consider correlations across ABR waveforms. A case study was also included to briefly assess the GP approach in ABR data from an adult volunteer

The "healthy dose" of nature: A cautionary tale

This is the author accepted manuscript. The final version is available on open access from Wiley via the DOI in this recordGrowing cross‐disciplinary interest in understanding if, how, and why time spent with nature can contribute to human health and well‐being has recently prompted efforts to identify an ideal healthy dose of nature; exposure to a specific type of nature at a specified frequency and duration. These efforts build on longstanding attempts to prescribe nature in some way, most recently in the form of so‐called “green prescriptions.” In this critical discussion paper, we draw on key examples from within the fields of health and cultural geography to encourage deeper and more critical reflection on the value of such reductionist dose‐response frameworks. By foregrounding the relationally emergent qualities of people's dynamic nature encounters, we suggest such efforts may be both illusory and potentially exclusionary for the many individuals and groups whose healthy nature interactions diverge from the statistical average or “normal” way of being. We suggest value in working towards alternative more‐than‐human approaches to health and well‐being, drawing on posthumanist theories of social practice. We present two practice examples—beach‐going and citizen science—to demonstrate how a focus on social practices can better cater for the diverse and dynamic ways in which people come to conceptualise, embody, and interpret nature in their everyday lives. We close by reflecting on the wider societal transformations required to foster greater respect for embodied difference and diversity.Economic and Social Research Council. Grant Number: ES/N015851/

‘Hopeful Adaptation’ in Health Geographies: seeking health and wellbeing in times of adversity

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordLiving with adversity can create wide-ranging challenges for people's health and wellbeing. This adversity may arise through personal embodied difference (e.g. acquiring a brain injury or losing mobility in older age) as well as wider structural relations that shape a person's capacity to adapt. A number of dichotomies have dominated our understanding of how people engage with health and wellbeing practices in their lives, from classifying behaviours as harmful/health-enabling, to understanding the self as being defined before/after illness. This paper critically interrogates a number of these dichotomies and proposes the concept of ‘hopeful adaptation’ to understand the myriad, often non-linear ways that people seek and find health and wellbeing in spite of adversity. We highlight the transformative potential in these adaptive practices, rather than solely focusing on how people persist and absorb adversity. The paper outlines an agenda for a health geography of hopeful adaptation, introducing a collection of papers that examine varied forms of adaptation in people's everyday struggles to find health and wellbeing whilst living with and challenging adversity

Envelope frequency following responses are stronger for high-pass than low-pass filtered vowels

Background: To assess hearing in response to speech, the envelope frequency following response (FFR) can be observed at the fundamental frequency of a vowel stimulus, and its harmonics. FFRs are complex non-linear phenomena, which require better understanding for allowing robust inferences on the assessment of hearing and hearing aid fitting. Objectives: To evaluate the effect of stimulus bandwidth on FFR detection rates using filtered vowel stimuli with equal sound levels. Design: FFRs were collected whilst presenting repeated vowels (in consonant-vowel-consonant format) filtered into different bandwidths. Eighty stimuli per word were presented at 70 dB SPL LAeq through insert earphones with an inter-stimulus interval of 1s. Responses were detected using frequency-domain Hotelling’s T2 (HT2) tests for individual multiples of the fundamental frequency (F0) and for combinations of F0 multiples. Study Sample: Eleven native English-speaking subjects with normal hearing thresholds. Results: Average detection rates are highest (69%) with stimuli high-pass filtered >1000 Hz, and significantly lower for low-pass filtered stimuli (40%). Conclusion: High-pass filtered vowels elicit stronger FFRs than low-pass filtered vowels at the same dB SPL LAeq. For testing hearing using band-limited speech, filtering effects (due to hearing loss, hearing aid setting or stimulus choice) on responses must be considered

Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex.

addresses: Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.notes: PMCID: PMC2817712types: Journal Article; Research Support, Non-U.S. Gov'tCopyright: © 2010 Bell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within these systems is tightly controlled to prevent unwanted crosstalk. One of the best understood two-component signalling pathways is the chemotaxis pathway. Here, we present the 1.40 A crystal structure of the histidine-containing phosphotransfer domain of the chemotaxis HPK, CheA(3), in complex with its cognate RR, CheY(6). A methionine finger on CheY(6) that nestles in a hydrophobic pocket in CheA(3) was shown to be important for the interaction and was found to only occur in the cognate RRs of CheA(3), CheY(6), and CheB(2). Site-directed mutagenesis of this methionine in combination with two adjacent residues abolished binding, as shown by surface plasmon resonance studies, and phosphotransfer from CheA(3)-P to CheY(6). Introduction of this methionine and an adjacent alanine residue into a range of noncognate CheYs, dramatically changed their specificity, allowing protein interaction and rapid phosphotransfer from CheA(3)-P. The structure presented here has allowed us to identify specificity determinants for the CheA-CheY interaction and subsequently to successfully reengineer phosphotransfer signalling. In summary, our results provide valuable insight into how cells mediate specificity in one of the most abundant signalling pathways in biology, two-component signal transduction