Evaluation of a grid-based river flow model using regional climate model output over Europe

Regional Climate Models (RCMs) offer significant improvements over Global Cli- mate Models in terms of their representation of rainfall at the spatial and temporal scales required for hydrological modelling. Here we test a new implementation of a grid-based hydrological model embedded in a model of land-surface climatology (the Joint UK Land Exchange Scheme; JULES) against observed river flows in sev- eral major NW European rivers, including the Rhine, Maas, Elbe, Danube, Loire, and Seine. Our hydrological model includes a probability-distributed model of soil mois- ture and runoff production (PDM) coupled with a discrete approximation to the one- dimensional kinematic wave equation to route surface and subsurface water downs- lope (G2G). The model was driven with hourly output from the Hadley Centre regional climate model, using results from the ERA-40 reanalysis experiment as boundary con- ditions (1961-2000). The results of simulations for river catchments in northwest Eu- rope are presented and compared with measured river flows over the same time period, for the same locations. The success with which the runoff production and flow routing components of the land-surface model match observed flow data is evaluated

Premature mortality in refractory partial epilepsy: does surgical treatment make a difference?

Background: Epilepsy carries an increased risk of premature death. For some people with intractable focal epilepsy, surgery offers hope for a seizure-free life. The authors aimed to see whether epilepsy surgery influenced mortality in people with intractable epilepsy. Methods: The authors audited survival status in two cohorts (those who had surgery and those who had presurgical assessment but did not have surgery). Results: There were 40 known deaths in the non-surgical group (3365 person years of follow-up) and 19 in the surgical group (3905 person-years of follow-up). Non-operated patients were 2.4 times (95% CI 1.4 to 4.2) as likely to die as those who had surgery. They were 4.5 times (95% CI 1.9 to 10.9) as likely to die a probable epilepsy-related death. In the surgical group, those with ongoing seizures 1 year after surgery were 4.0 (95% CI 1.2 to 13.7) times as likely to die as those who were seizure-free or who had only simple partial seizures. Time-dependent Cox analysis showed that the yearly outcome group did not significantly affect mortality (HR 1.3, 95% CI 0.9 to 1.8). Conclusion: Successful epilepsy surgery was associated with a reduced risk of premature mortality, compared with those with refractory focal epilepsy who did not have surgical treatment. To some extent, the reduced mortality is likely to be conferred by inducing freedom from seizures. It is not certain whether better survival is attributable only to surgery, as treatment decisions were not randomised, and there may be inherent differences between the groups.<br/

From Quasars to Extraordinary N-body Problems

We outline reasoning that led to the current theory of quasars and look at George Contopoulos's place in the long history of the N-body problem. Following Newton we find new exactly soluble N-body problems with multibody forces and give a strange eternally pulsating system that in its other degrees of freedom reaches statistical equilibrium.Comment: 13 pages, LaTeX with 1 postscript figure included. To appear in Proceedings of New York Academy of Sciences, 13th Florida Workshop in Nonlinear Astronomy and Physic

A Working Catalogue of Herbig Haro Objects

We present a catalogue of 184 Herbig Haro objects from a literature search complete to 1987.5. It is intended to update the 1974 catalogue of Herbig. The catalogue contains accurate co-ordinates, proper motions, radial velocities and spectral information for these objects. A cross-reference to the two best finding charts is included. A grouping of Herbig Haro objects into is also listed

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process. METHODS: We used Affymetrix oligonucleotide microarrays to perform a detailed transcript analysis on the mechanism of controlled involution after withdrawal of the pups at day seven of lactation. Some of the results were confirmed by semi-quantitative reverse transcriptase polymerase chain reaction, Western blotting or immunohistochemistry. RESULTS: We identified 145 genes that were specifically upregulated during the first 4 days of involution; of these, 49 encoded immunoglobulin genes. A further 12 genes, including those encoding the signal transducer and activator of transcription 3 (STAT3), the lipopolysaccharide receptor (CD14) and lipopolysaccharide-binding protein (LBP), were involved in the acute-phase response, demonstrating that the expression of acute-phase response genes can occur in the mammary gland itself and not only in the liver. Expression of LBP and CD14 was upregulated, at both the RNA and protein level, immediately after pup withdrawal; CD14 was strongly expressed in the luminal epithelial cells. Other genes identified suggested neutrophil activation early in involution, followed by macrophage activation late in the process. Immunohistochemistry and histological staining confirmed the infiltration of the involuting mammary tissue with neutrophils, plasma cells, macrophages and eosinophils. CONCLUSION: Oligonucleotide microarrays are a useful tool for identifying genes that are involved in the complex developmental process of mammary gland involution. The genes identified are consistent with an immune cascade, with an early acute-phase response that occurs in the mammary gland itself and resembles a wound healing process

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

AbstractA cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.GlucagonEvolutionHystricomorphcDNAGlycogenolytic hormon

Development and Validation of a Military Training Mental Toughness Inventory

Three studies were conducted in order to develop and validate a mental toughness instrument for use in military training environments. Study 1 (n = 435) focused on item generation and testing the structural integrity of the Military Training Mental Toughness Inventory (MTMTI). The measure assessed ability to maintain optimal performance under pressure from a range of different stressors experienced by recruits during infantry basic training. Study 2 (n = 104) examined the concurrent validity, predictive validity, and test-retest reliability of the measure. Study 3 (n = 106) confirmed the predictive validity of the measure with a sample of more specialized infantry recruits. Overall, the military training mental toughness inventory demonstrated sound psychometric properties and structural validity. Furthermore, it was found to possess good test-retest reliability, concurrent validity, and predicted performance in two different training contexts with two separate samples

On the Role of Density Matrices in Bohmian Mechanics

It is well known that density matrices can be used in quantum mechanics to represent the information available to an observer about either a system with a random wave function (``statistical mixture'') or a system that is entangled with another system (``reduced density matrix''). We point out another role, previously unnoticed in the literature, that a density matrix can play: it can be the ``conditional density matrix,'' conditional on the configuration of the environment. A precise definition can be given in the context of Bohmian mechanics, whereas orthodox quantum mechanics is too vague to allow a sharp definition, except perhaps in special cases. In contrast to statistical and reduced density matrices, forming the conditional density matrix involves no averaging. In Bohmian mechanics with spin, the conditional density matrix replaces the notion of conditional wave function, as the object with the same dynamical significance as the wave function of a Bohmian system.Comment: 16 pages LaTeX, no figure

A review of the Spyridium eriocephalum complex (Rhamnaceae: Pomaderreae)

Spyridium eriocephalum Fenzl and related taxa are described and illustrated, following a recent molecular analysis of the genus. The variety of the species endemic to Kangaroo Island is raised to specific rank, as S. glabrisepalum (J.M.Black) Kellermann & C.Clowes. The following new taxa are published: Spyridium latifolium Kellermann from the Fleurieu Peninsula (S.A.) and S. undulifolium Kellermann & S.A.J.Bell from the Goulburn River area (N.S.W.). The population of an entity with historical collections close to the latter species requires re-collection and further examination before a decision can be made as to its status; it is provisionally given the phrase name Spyridium sp. Dingo Creek (T. Tame 1011) Kellermann. Spyridium eriocephalum s.str. is widespread, mainly in mallee areas of southern Australia, extending to the Central Mallee in New South Wales, an occurrence in the Victorian Alps, as well as two locations in Tasmania. A key to all taxa of the species-complex is provided.Jürgen Kellermann, Catherine Clowes, Stephen A.J. Bel