1,256 research outputs found
Premelting of Thin Wires
Recent work has raised considerable interest on the nature of thin metallic
wires. We have investigated the melting behavior of thin cylindrical Pb wires
with the axis along a (110) direction, using molecular dynamics and a
well-tested many-body potential. We find that---in analogy with cluster
melting---the melting temperature of a wire with radius is lower
than that of a bulk solid, , by . Surface melting
effects, with formation of a thin skin of highly diffusive atoms at the wire
surface, is observed. The diffusivity is lower where the wire surface has a
flat, local (111) orientation, and higher at (110) and (100) rounded areas. The
possible relevance to recent results on non-rupturing thin necks between an STM
tip and a warm surface is addressed.Comment: 10 pages, 4 postscript figures are appended, RevTeX, SISSA Ref.
131/94/CM/S
Discrete Symmetries and Generalized Fields of Dyons
We have studied the different symmetric properties of the generalized
Maxwell's - Dirac equation along with their quantum properties. Applying the
parity (\mathcal{P}), time reversal (\mathcal{T}), charge conjugation
(\mathcal{C}) and their combined effect like parity time reversal
(\mathcal{PT}), charge conjugation and parity (\mathcal{CP}) and \mathcal{CP}T
transformations to varius equations of generalized fields of dyons, it is shown
that the corresponding dynamical quantities and equations of dyons are
invariant under these discrete symmetries.
Abstract Key words- parity, time reversal, charge-conjugation, dyons
Abstract PACS No.- 14.80 Hv
Stringent Constraints on Cosmological Neutrino-Antineutrino Asymmetries from Synchronized Flavor Transformation
We assess a mechanism which can transform neutrino-antineutrino asymmetries
between flavors in the early universe, and confirm that such transformation is
unavoidable in the near bi-maximal framework emerging for the neutrino mixing
matrix. We show that the process is a standard Mikheyev-Smirnov-Wolfenstein
flavor transformation dictated by a synchronization of momentum states. We also
show that flavor ``equilibration'' is a special feature of maximal mixing, and
carefully examine new constraints placed on neutrino asymmetries. In
particular, the big bang nucleosynthesis limit on electron neutrino degeneracy
xi_e < 0.04 does not apply directly to all flavors, yet confirmation of the
large-mixing-angle solution to the solar neutrino problem will eliminate the
possibility of degenerate big bang nucleosynthesis.Comment: 11 pages, 6 figures; minor changes to match PRD versio
Efficient Algorithm on a Non-staggered Mesh for Simulating Rayleigh-Benard Convection in a Box
An efficient semi-implicit second-order-accurate finite-difference method is
described for studying incompressible Rayleigh-Benard convection in a box, with
sidewalls that are periodic, thermally insulated, or thermally conducting.
Operator-splitting and a projection method reduce the algorithm at each time
step to the solution of four Helmholtz equations and one Poisson equation, and
these are are solved by fast direct methods. The method is numerically stable
even though all field values are placed on a single non-staggered mesh
commensurate with the boundaries. The efficiency and accuracy of the method are
characterized for several representative convection problems.Comment: REVTeX, 30 pages, 5 figure
Effects of shoot tipping on development and yield of the tuber crop Plectranthus edulis
Plectranthus edulis (Vatke) Agnew is one of the tuber crops of the genus Plectranthus that is widely cultivated in Africa and Asia. P. edulis produces below-ground tubers on stolons originating from the stems, comparable to the potato (Solanum tuberosum L.). Farmers apply several laborious cultural practices to enhance shoot growth and yield, among which shoot tipping is very common. Tipping (pinching) is the removal of the shoot apex with one or two pairs of leaves from the main stems and branches. The rationale of this practice, especially when repeated more than once during one cropping season, is not fully understood. One similar experiment with two cultivars was carried out at two locations (Awassa and Wondogenet) in Ethiopia to assess and analyse the effects of shoot tipping and its frequency on crop development and tuber production. Tipping treatments included zero tipping, tipping once, tipping twice and tipping thrice, with the first tipping taking place 68 days after planting (DAP), a stage at which most of the stems reached a height of about 0·15 m, and the remainder following at intervals of 44–46 days. Tipping stimulated stem branching; it significantly increased the number of primary, secondary and tertiary stems in both experiments. Soil cover increased with an increase in the frequency of the tipping in Awassa, because of the tipping effects on the different canopy development variables. Tipping also enhanced the soil cover in Wondogenet, but the crop did not gain any extra benefit from a third tipping. Tipping enhanced early stolon formation, but did not consistently affect the number of stolons per hole later in the growing season. The number of tubers increased with an increase in the frequency of tipping in both cultivars in Wondogenet and in one cultivar in Awassa. Tuber dry matter yield increased with an increase in the frequency of tipping at both sites. Fresh tuber yield in the final harvest at 208 DAP was c. 1·9 kg/m2. Tipping on average increased fresh tuber yield by 17% in Wondogenet, whereas the difference was not detectable in Awassa. Because senescence was delayed slightly by tipping, yield effects of tipping might be larger when harvesting later. In general, there was a positive effect of tipping on canopy development and tuber yield
Multipartite entangled states in coupled quantum dots and cavity-QED
We investigate the generation of multipartite entangled state in a system of
N quantum dots embedded in a microcavity and examine the emergence of genuine
multipartite entanglement by three different characterizations of entanglement.
At certain times of dynamical evolution one can generate multipartite entangled
coherent exciton states or multiqubit states by initially preparing the
cavity field in a superposition of coherent states or the Fock state with one
photon, respectively. Finally we study environmental effects on multipartite
entanglement generation and find that the decay rate for the entanglement is
proportional to the number of excitons.Comment: 9 pages, 4 figures, to appear in Phys. Rev.
Integrating Biology and Access to Care in Addressing Breast Cancer Disparities: 25 Years’ Research Experience in the Carolina Breast Cancer Study
Purpose of Review: To review research on breast cancer mortality disparities, emphasizing research conducted in the Carolina Breast Cancer Study, with a focus on challenges and opportunities for integration of tumor biology and access characteristics across the cancer care continuum. Recent Findings: Black women experience higher mortality following breast cancer diagnosis, despite lower incidence compared to white women. Biological factors, such as stage at diagnosis and breast cancer subtypes, play a role in these disparities. Simultaneously, social, behavioral, environmental, and access to care factors are important. However, integrated studies of biology and access are challenging and it is uncommon to have both data types available in the same study population. The central emphasis of phase 3 of the Carolina Breast Cancer Study, initiated in 2008, was to collect rich data on biology (including germline and tumor genomics and pathology) and health care access in a diverse study population, with the long-term goal of defining intervention opportunities to reduce disparities across the cancer care continuum. Summary: Early and ongoing research from CBCS has identified important interactions between biology and access, leading to opportunities to build greater equity. However, sample size, population-specific relationships among variables, and complexities of treatment paths along the care continuum pose important research challenges. Interdisciplinary teams, including experts in novel data integration and causal inference, are needed to address gaps in our understanding of breast cancer disparities
H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells
Among eight human bladder cancer cell lines we examined, only T24 cells were resistant to the growth inhibition effect of genistein, an isoflavone and potent anticancer drug. Since the T24 cell line was the only cell line known to overexpress oncogenic H-Ras(val12), we investigated the role of H-Ras(val 12) in mediating drug resistance. Herein, we demonstrate that the phenotype of T24 cells could be dramatically reversed and became relatively susceptible to growth inhibition by genistein if the synthesis of H- Ras(val 12) or its downstream effector c-Fos had been suppressed. The inhibition of Ras-mediated signalling with protein kinase inhibitors, such as PD58059 and U0126 which inhibited MEK and ERK, in T24 cells also rendered the identical phenotypic reversion. However, this reversion was not observed when an inhibitor was used to suppress the protein phosphorylation function of PI3 K or PKC. These results suggest that the signal mediated by H-Ras(val 12) is predominantly responsible for the resistance of the cells to the anticancer drug genistein
Nash Equilibria in Discrete Routing Games with Convex Latency Functions
In a discrete routing game, each of n selfish users employs a mixed strategy to ship her (unsplittable) traffic over m parallel links. The (expected) latency on a link is determined by an arbitrary non-decreasing, non-constant and convex latency function φ. In a Nash equilibrium, each user alone is minimizing her (Expected) Individual Cost, which is the (expected) latency on the link she chooses. To evaluate Nash equilibria, we formulate Social Cost as the sum of the users ’ (Expected) Individual Costs. The Price of Anarchy is the worst-case ratio of Social Cost for a Nash equilibrium over the least possible Social Cost. A Nash equilibrium is pure if each user deterministically chooses a single link; a Nash equilibrium is fully mixed if each user chooses each link with non-zero probability. We obtain: For the case of identical users, the Social Cost of any Nash equilibrium is no more than the Social Cost of the fully mixed Nash equilibrium, which may exist only uniquely. Moreover, instances admitting a fully mixed Nash equilibrium enjoy an efficient characterization. For the case of identical users, we derive two upper bounds on the Price of Anarchy: For the case of identical links with a monomial latency function φ(x) = x d, the Price of Anarchy is the Bell number of order d + 1. For pure Nash equilibria, a generic upper bound from the Wardrop model can be transfered to discrete routing games. For polynomial latency functions with non-negative coefficients and degree d, this yields an upper bound of d + 1. For th
Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery
In this study, we investigated the role of protein disulphide isomerase (PDI) in rapid metabolism of S-nitrosoglutathione (GSNO) and S-nitrosoalbumin (albSNO) and in NO delivery from these compounds into cells. Incubation of GSNO or albSNO (1 μM) with the megakaryocyte cell line MEG-01 resulted in a cell-mediated removal of each compound which was inhibited by blocking cell surface thiols with 5,5′-dithiobis 2-nitrobenzoic acid (DTNB) (100 μM) or inhibiting PDI with bacitracin (5 mM). GSNO, but not albSNO, rapidly inhibited platelet aggregation and stimulated cyclic GMP (cGMP) accumulation (used as a measure of intracellular NO entry). cGMP accumulation in response to GSNO (1 μM) was inhibited by MEG-01 treatment with bacitracin or DTNB, suggesting a role for PDI and surface thiols in NO delivery. PDI activity was present in MEG-01 conditioned medium, and was inhibited by high concentrations of GSNO (500 μM). A number of cell surface thiol-containing proteins were labelled using the impermeable thiol specific probe 3-(N-maleimido-propionyl) biocytin (MPB). Pretreatment of cells with GSNO resulted in a loss of thiol reactivity on some but not all proteins, suggesting selective cell surface thiol modification. Immunoprecipitation experiments showed that GSNO caused a concentration-dependent loss of thiol reactivity of PDI. Our data indicate that PDI is involved in both rapid metabolism of GSNO and intracellular NO delivery and that during this process PDI is itself altered by thiol modification. In contrast, the relevance of PDI-mediated albSNO metabolism to NO signalling is uncertain
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