Sustainable development of smallholder crop-livestock farming in developing countries

Meeting the growing demand for animal-sourced food, prompted by population growth and increases in average per-capita income in low-income countries, is a major challenge. Yet, it also presents significant potential for agricultural growth, economic development, and reduction of poverty in rural areas. The main constraints to livestock producers taking advantage of growing markets include; lack of forage and feed gaps, communal land tenure, limited access to land and water resources, weak institutions, poor infrastructure and environmental degradation. To improve rural livelihood and food security in smallholder crop-livestock farming systems, concurrent work is required to address issues regarding efficiency of production, risk within systems and development of whole value chain systems. This paper provides a review of several forage basedstudies in tropical and non-tropical dry areas of the developing countries. A central tenet of this paper is that forages have an essential role in agricultural productivity, environmental sustainability and livestock nutrition in smallholder mixed farming systems

Demonstration That Circulating 1α,25-Dihydroxyvitamin D is Loosely Regulated in Normal Children

The effects of vitamin D, 2.5 mg (100,000 U)/d for 4 d, on serum calcium, serum 25-hydroxyvitamin D (25-OHD) and serum 1a,25-dihydroxyvitamin D (1a,25(OH)2D) were compared in 24 normal adults and 12 normal children. The daily dose of vitamin D was 1,500 U/kg body wt in children weighing \u3c45 kg. Vitamin D increased mean serum calcium from 9.5±0.1 to 9.8±0.1 mg/dl (P \u3c 0.05), increased mean serum phosphorus from 4.6±0.1 to 5.0±0.1 mg/dl (P \u3c 0.01), increased mean serum 25-OHD from 25±3 to 34±4 ng/ml (P \u3c 0.001), and increased mean serum 1a,25(OH)2D from 34±3 to 42±4 pg/ml (P \u3c 0.02) in children. In contrast, vitamin D increased mean serum 25-OHD from 18±2 to 39±6 ng/ml (P \u3c 0.001) and did not change mean serum calcium (9.4±0.1 vs. 9.5±0.1 mg/dl), mean serum phosphorus (4.0±0.1 vs. 4.1±0.1 mg/dl), or mean serum 1a,25(OH)2D (31±2 vs. 29±3 pg/ml) in adults. Mean serum 1a,25(OH)2D was significantly higher after vitamin D in children than in adults (P \u3c 0.02). These results provide evidence that circulating 1a,25(OH)2D is not as tightly regulated in children as it is in adults. This difference in regulation could account in part for the higher values for serum 1a,25(OH)2D observed in children

Increased Calcium Intake Does Not Suppress Circulating 1,25-Dihydroxyvitamin D in Normocalcemic Patients with Sarcoidosis

Ca absorption is regulated by 1,25(OH)2D, and serum values vary inversely with Ca intake. In sarcoidosis, 1,25(OH)2D is produced by alveolar macrophages in response to y-interferon, and patients may develop hypercalcemia after prolonged exposure to sunlight and increased dermal production of vitamin D3. To determine if increased Ca intake suppresses serum 1,25(OH)2D in normocalcemic patients and to identify those at risk, 17 normal subjects and 11 patients were studied on a metabolic ward for two and one-half days while receiving first 400 and then 1,000 mg/d of Ca. On the low Ca intake, serum angiotensin-converting enzyme (ACE), an index of disease activity, was higher in only three of the patients than in the controls, mean serum 1,25(OH)2D was higher in the patients, and mean serum total Ca, serum Ca , and urinary Ca were not different in the two groups. On the higher Ca intake, mean urinary Ca increased in both groups, but mean serum 1,25(OH)2D was suppressed only in the normal subjects. Thus, 1,25(OH)2D production is abnormally regulated, indicating that (a) normocalcemic patients with sarcoidosis are at risk for developing abnormal Ca metabolism, and (b) a better index of disease activity is provided by the oral Ca suppression test than by serum ACE. (J. Clin. Invest. 1993. 91:1396- 1398.

Formation of X-Ray Cavities by the Magnetically Dominated Jet-Lobe System in a Galaxy Cluster

We present cosmological magnetohydrodynamic simulations of the formation of a galaxy cluster with magnetic energy feedback from an active galactic nuclei (AGN). We demonstrate that X-ray cavities can be produced by the magnetically dominated jet-lobe system that is supported by a central axial current. The cavities are magnetically dominated and their morphology is determined jointedly by the magnetic fields and the background cluster pressure profile. The expansion and motion of the cavities are driven initially by the Lorentz force of the magnetic fields, and the cavities only become buoyant at late stages ($> 500$ Myr). We find that up to $80$ of the injected magnetic energy goes into doing work against the hot cluster medium, heating it, and lifting it in the cluster potential.Comment: 11 pages, 3 figures, minor correction

Evidence for Extrarenal Production of 1a,25-Dihydroxyvitamin D in Man

Recent studies provide evidence for extrarenal production of 1a,25-dihydroxyvitamin D [1a,25(OH)2D]. To investigate this possibility, serum vitamin D, 25-hydroxyvitamin D (25-OHD), 24,25-dihydroxyvitamin D [24,25(OH)2D], and 1a,25(OH)2D were measured in eight adult anephric subjects. All were undergoing hemodialysis and three of them were receiving vitamin D, 50,000 or 100,000 U/d. Serum vitamin D was elevated in two of the patients given vitamin D and was abnormally low in the others. Mean serum 25-OHD was increased in patients given vitamin D (94.0±7.6 ng/ml) and was normal in the others (16.4±0.9 ng/ml, P \u3c 0.001). Mean serum 24,25(OH)2D was normal in patients given vitamin D (1.38±0.27 ng/ml) and was low in the others (0.25±0.08 ng/ml, P \u3c 0.001). Serum 24,25(OH)2D correlated significantly with serum 25-OHD (r = 0.848, P \u3c 0.01). Mean serum 1a,25(OH)2D determined by receptor assay was 5.8±1.9 pg/ml in patients who were not given vitamin D and was 14.1±0.6 in those who were given vitamin D (P \u3c 0.001). Serum 1a,25(OH)2D correlated significantly with serum 25-OHD (r = 0.911, P \u3c 0.01). Mean serum 1a,25(OH)2D, measured by bioassay, was 8.3±1.9 pg/ml in patients who were not given vitamin D and was 15.9±2.4 pg/ml in those who were given vitamin D (P \u3c 0.05). There was a significant correlation between the values for serum 1a,25(OH)2D obtained with the two methods (r = 0.728, P \u3c 0.01). The results (a) provide evidence in man for extrarenal production of both 24,25(OH)2D and, by two independent assays, of 1a,25(OH)2D, and (b) indicate that serum values of the two dihydroxy metabolites of vitamin D in anephric subjects vary with the serum concentration of the precursor 25-OHD

The Australian Cancer Anaemia Survey: a snapshot of anaemia in adult patients with cancer

The document attached has been archived with permission from the editor of the Medical Journal of Australia (09 January 2008). An external link to the publisher’s copy is included.Objective: To evaluate the frequency and management of anaemia in Australian adults with solid and haematological malignancies. Design: 6-month observational, prospective, multicentre study. Participants: 694 patients recruited from outpatient oncology clinics in 24 hospitals in five Australian states between 9 April 2001 and 31 July 2001. Main outcome measures: Frequency of anaemia (haemoglobin [Hb] level < 120 g/L) at enrolment and over ensuing 6 months, by tumour type, disease status and cancer treatment; anaemia treatment and “trigger” Hb level for this treatment. Results: Participants had median age 60 years, and 61% were women. Prevalence of anaemia at enrolment was 35% (199/562), with 78% of these 199 having mild anaemia (Hb, 100–119 g/L). Frequency of anaemia (either present at enrolment or developing during the study) was 57% overall (323/566), and varied with tumour type, from 49% (lymphoma/myeloma) to 85% (urogenital cancer). Patients who received radiotherapy either in combination or concomitant with chemotherapy were more likely to have anaemia (73%) than those receiving chemotherapy alone (58%) (P = 0.004). Of all chemotherapy patients not anaemic at enrolment, 23% developed anaemia by the second monthly follow-up. Independent predictors for anaemia in chemotherapy patients were low baseline Hb level (odds ratio [OR], 5.4; 95% CI, 2.7–10.9) and use of platinum chemotherapeutic agents (OR, 4.8; 95% CI, 2.1–11.4) (P < 0.001). Anaemia was treated in 41% of patients with anaemia at enrolment — by transfusion (36%), iron (5%) and erythropoietic agents (2%). Frequency of anaemia treatment varied between tumour types, from 19% (breast cancer) to 60% (leukaemia). The mean “trigger Hb” for initiating transfusion was 95 g/L. Conclusions: Anaemia is prevalent among Australian patients with cancer managed in hospital oncology units. Its management varies between tumour types. Many patients do not receive treatment for their anaemia.Tara Seshadri, H Miles Prince, David R Bell, Paul B Coughlin, Philip P B James, Gary E Richardson, Boris Chern, Peter Briggs, John Norman, Ian N Olver, Chris Karapetis and John Stewart, for the Australia Cancer Anaemia Study (ACAS) Grou

Core Blighty? How Journalists Define Themselves Through Metaphor

Journalism has long relied on certain core metaphors in order to express its claims to social and political usefulness. The deployment of metaphors to describe a practice that in contrast asserts its truth-telling and plain prose style is in itself interesting. Since metaphor acts as a powerful indicator of presuppositions it can be used to reify complex public discourses, reducing them to common-sense thinking. This paper will explore what metaphors have been used in association with journalism in the pages of the British Journalism Review since the closure of the News of the World. This publication was launched in 1989 in response to a previous crisis in public and professional confidence in journalism and has since then provided an intriguing insider dialogue on developments within the area. Do metaphorical articulations of the current role and image of journalism demonstrate an awareness among journalists of changes in its values or do they rather tend to reinforce more traditional attitudes to a practice under threat? Post-Leveson what can the patterning of such figurative language across articles by a wide range of prominent journalists in the UK tell us about the values and aspirations of journalists in a time when journalism is under intense scrutiny