Enterprise Adjustment in Poland: Evidence from a Survey of 200 Private

This paper reports the main findings from a survey of some 200 Polish firms carried out at the end of 1993. The central focus is on the relationship between different emerging forms of ownership and the extent and nature of enterprise level adjustments taking place. Four broad categories of enterprises that distinguish the main ownership forms that characterize Polish industry were included in the survey: (a) traditional state-owned enterprises, (b) corporatized state-owned enterprises that have been converted into joint stock companies but whose shares are now owned by the State Treasury; (c) former state-owned firms that have been privatized; and (d) privately-owned firms which were established de novo. Some of the main findings from the survey are as follows. Growth and investment in 1993 were widely diffused through the economy, but rather more concentrated in the private sector and especially in de novo private firms, while financial distress as revealed by low profit margins was concentrated in the state-owned sector. The survey suggests that all firms in Poland have experienced a considerable increase in competition, and have faced the need radically to restructure their patterns of input purchases and marketing strategy. In general, de novo private firms have led the way, and changes have been fewer and less deep in the state-owned sector. Developments on the labor side in our sample are rather modest, and to be heavily oriented to satisfy the preferences of insiders, especially workers. Overmanning remains rife in both the state-owned and privatized sector, and differences between the two groups of firms in wage determination appear to stem more from the operation of the excess wage tax than from differences in motivation. Behavior in the de novo private firms is, however, clearly different, with a concern to hire not fire, and with lower employee influence. With respect to finance, we find that privatized and especially de novo private firms are financially relatively healthy, with higher profits and fewer bad debts than the state-owned firms. Although almost half of private sector firms hold no bank debt, bank credit is flowing fastest to these firms and in general they report the fewest problems in servicing it. Overdue trade credit is common among all ownership groups but more so among state firms; however, the flow problem is not serious, and volumes of total and overdue trade credit are comparable to West European levels. The main method by which severely financially-distressed firms, nearly all of which are state-owned, finance their losses is by running up tax arrears; financing by banks and by trade credit is much less significant.

South Chattanooga and Chattanooga Creek floodplain: A case study

South Chattanooga, Tennessee, has been the object of numerous investigations due to its large minority population and industrial history. Utilizing the case study approach, the area was examined as both an environmental justice community and home to an active Superfund site. Through legal analysis, historical research, environmental sampling, and government agency assessment, patterns emerged. The patterns provided a means for comparison with other communities in similar situations. The comparisons allowed for the formulation of several recommendations. The community\u27s proximity to the heavily polluted Chattanooga Creek was a key component of the South Chattanooga case study. Chattanooga Creek flows through the heart of South Chattanooga and has been an industrial dumping ground for over 100 years. Decades of pollution and frequent flooding events gave rise to community concern regarding contact with the Creek. As a result, Chattanooga Creek was included on the National Priorities List (NPL) and a Superfund site investigation commenced. After several site investigations and some Creek remediation, the United States Environmental Protection Agency (EPA) awarded the City of Chattanooga a Superfund Redevelopment Initiative (SRI) pilot grant. Portions of the grant were used to develop a detailed Superfund site reuse plan. The reuse plan proposed a greenway linking individual South Chattanooga communities to Chattanooga Creek and to one another. The greenway and park would offer recreational opportunities and would run through the floodplain along the entire length of the Chattanooga Creek Superfund site. Due to persistent flooding of Chattanooga Creek and lingering questions about the adequacy of past and proposed removal actions, South Chattanooga citizens were not convinced that the floodplain was safe enough to accommodate public use without additional remediation. To address this concern, the Biological and Environmental Sciences Department at The University of Tennessee at Chattanooga (UTC), the Center for the Management, Utilization, and Protection of Water Resources at Tennessee Technological University (TTU), and the local environmental justice community organization Stop Toxic Pollution (S.T.O.P.), requested a grant from EPA\u27s Region IV Office of Environmental Justice. EPA funded the Chattanooga Creek Hazardous Substances Monitoring Program grant, which allowed for environmental sampling of the Chattanooga Creek floodplain. The results of the floodplain sampling showed soil polycyclic aromatic hydrocarbon (PAH) levels above several EPA Region IV remediation guidelines. Although guidelines are not legally enforceable, the remediation guidelines are the only guidance provided for this type of site assessment. As a result, South Chattanooga citizens indicated that the greenway, as proposed, should not be constructed without further remediation of floodplain soils. Despite EPA guideline exceedance and community concern, the Agency for Toxic Substances and Disease Registry (ATSDR) issued a Health Consultation that declared no apparent public health hazard existed from contact with soil PAH contamination. Because of the discrepancy between guideline exceedance and the ATSDR conclusion, other Superfund communities were investigated for comparison purposes. Five Superfund communities from different EPA regions were analyzed. Major discrepancies between EPA Superfund remediation projects were discovered. The primary causes were a lack of guideline consistency, inconsistent interpretation of relevant environmental laws, and undeterminable risk associated with PAH mixtures. Although South Chattanooga\u27s struggle was by no means unique, understanding the complexities associated with Superfund remediation and environmental justice communities were essential in order to provide recommendations for agency discrepancy and the risk assessment process. This thesis will identify the multiple factors that impede remediation of the Chattanooga Creek floodplain and hinder efforts by South Chattanooga residents to achieve environmental justice

The Okun Misery Index in the European Union Countries from 2000 to 2009

The study is composed of four main parts and a summary. The first part, introduction, discusses various measures of the economic system's efficiency that are used in practice. Part two emphasises that the GDP per capita according to purchasing power parity still remains the most popular among those measures. Further, it presents the ranking of the European Union countries taking that measure into account, the research period being 1999-2009. Part three points out that it is also the level of poverty (misery) that determines the economic system's efficiency. That level can be measured by means of various indicators, among others, the so called HPI-2 index calculated by the UN. It will be the Okun misery index, however, computed as the sum of inflation and unemployment rates that will be presented as an alternative being of interest from the macroeconomic point of view. The ranking of the European Union member states according to that measure in the 2000-2004 and 2005-2009 periods will be provided in part four. The article will end in a summary containing synthetic conclusions drawn from earlier observations.Opracowanie składa się z czterech części zasadniczych i podsumowania. W punkcie pierwszym omówiono różnorodne mierniki sprawności systemu gospodarczego wykorzystywane w praktyce. W części drugiej podkreślono, iż nadal najpopularniejszym z nich jest PKB per capita według parytetu siły nabywczej. Zgodnie z tym miernikiem przedstawiono ranking państw Unii Europejskiej w latach 1999-2009. W punkcie trzecim podkreślono, że o sprawności systemu gospodarczego decyduje także poziom ubóstwa. Może być on mierzony różnymi wskaźnikami, m.in. tzw. indeksem HPI-2 obliczanym przez ONZ. Jako ciekawą z makroekonomicznego punktu widzenia alternatywę ukazano jednak miarę wskaźnika ubóstwa Okuna obliczanego poprzez zsumowanie stopy inflacji i stopy bezrobocia. Ranking państw Unii Europejskiej według tej miary w okresach 2000-2004 oraz 2005-2009 zaprezentowano w części czwartej. Całość zamknięto podsumowaniem, w którym zawarto syntetyczne wnioski z przeprowadzonych obserwacji

The Role of Magmatism in Hydrocarbon Generation in Sedimented Rifts: a Nd Isotope Perspective from Mid-Cretaceous Methane-Seep Deposits of the Basque-Cantabrian Basin, Spain

Studies on the involvement of intrusive magmatism in hydrocarbon generation within sedimentary basins have gained momentum owing to increasing appraisal of the role that such processes may play in controlling global carbon cycle perturbations, and the exploration potential of the volcanic sedimentary basins. Nevertheless, for many areas the causal link between the intrusions and surrounding hydrocarbon systems remains disputed, encouraging a search for methods that could aid in identifying different hydrocarbon sources. Here, we have performed a multi-proxy geochemical study of the middle Cretaceous methane-seep deposits of the Basque-Cantabrian Basin, an early-stage, peri-cratonic rift marking the Mesozoic opening of the Bay of Biscay. Infilled by a thick sedimentary succession intruded by shallow-level igneous bodies, the basin shares analogies with modern young, sedimented rifts that sustain hydrocarbon seepage. We have applied a novel approach that uses the Nd isotope composition of the seep deposits to constrain the relationship between hydrocarbon seepage and igneous activity, and to explore the general potential of Nd isotopes to trace magmatic-influenced fluids in volcanic sedimentary basins. The Nd isotope data have been combined with rare earth element analyses and carbon and oxygen isotope measurements, providing broad insight into the former composition of the seeping fluids. For three out of four investigated seeps, the Nd isotope ratios observed in authigenic seep carbonates include signatures markedly more radiogenic than that reconstructed for background seawater-derived pore waters. The level of this Nd-143-enrichment varies both between and within individual deposits, reflecting spatial and temporal differences in fluid composition typical of seep-related environments. The radiogenic Nd isotope signals provide evidence of subseafloor interactions between the seeping fluids and mafic igneous materials, supporting the model of an igneous control on the mid-Cretaceous methane expulsion in the Basque-Cantabrian Basin. The thermogenic origin of the methane is in accord with the moderately negative delta C-13 values and paragenetic successions observed in the studied seep carbonates. For a single deposit, its relatively unradiogenic Nd isotope composition can be attributed to the smallest size and shallowest emplacement depth of the underlying intrusion, likely resulting in a short-lived character and limited hydrocarbon-generation potential of the associated contact metamorphism. The study demonstrates that Nd isotope analyses of seep carbonates offer a tool in disentangling methane fluxes from different organic matter alteration pathways for the numerous, both fossil and modern sedimented rifts for which the involvement of various methane sources remains insufficiently understood.This work was supported by the National Science Centre, Poland (grant No. 2016/23/D/ST10/00444; to MJ) , and the Eusko Jaurlaritza (Ikerketa Taldeak IT930-16) and the Spanish State Research Agency (project PID2019-105670GB-I00/AEI/10.13039/501100011033; both to LMA

Combination of celecoxib with percutaneous radiotherapy in patients with localised prostate cancer – a phase I study

BACKGROUND: Current approaches for the improvement of bNED for prostate cancer patients treated with radiotherapy mainly focus on dose escalation. However molecularly targeted approaches may also turn out to be of value. In this regard cyclooxygenase (COX)-2 inhibitors have been shown to exert some anti-tumour activities in human prostate cancer in vivo and in vitro. Although in vitro data indicated that the combination of COX-2 inhibition and radiation was not associated with an increased toxicity, we performed a phase I trial using high dose celecoxib together with percutaneous radiation therapy. METHODS: In order to rule out any increases of more than 20% incidence for a given side effect level 22 patients were included in the trial. Celecoxib was given 400 mg twice daily with onset of the radiation treatment. Risk adapted radiation doses were between 70 and 74 Gy standard fractionation. RTOG based gastrointestinal (GI) and genitourinary (GU) acute toxicity scoring was performed weekly during radiation therapy, at six weeks after therapy and three month after completing radiation treatment. RESULTS: Generally no major increase in the level and incidence of side effects potentially caused by the combined treatment was observed. In two cases a generalised skin rash occurred which immediately resolved upon discontinuation of the drug. No grade 3 and 4 toxicity was seen. Maximal GI toxicity grade 1 and 2 was observed in 85% and 10%, respectively. In terms of GU toxicity 80 % of the patients experienced a grade 1 toxicity and 10 % had grade 2 symptoms. CONCLUSION: The combination of irradiation to the prostate with concurrent high dose celecoxib was not associated with an increased level of side effects

Evaluation of daily patient positioning for radiotherapy with a commercial 3D surface-imaging system (Catalyst (TM))

Background: To report our initial clinical experience with the novel surface imaging system Catalyst (TM) (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator for daily patient positioning in patients undergoing radiation therapy. Methods: We retrospectively analyzed the patient positioning of 154 fractions in 25 patients applied to thoracic, abdominal, and pelvic body regions. Patients were routinely positioned based on skin marks, shifted to the calculated isocenter position and treated after correction via cone beam CT which served as gold standard. Prior to CBCT an additional surface scan by the Catalyst (TM) system was performed and compared to a reference surface image cropped from the planning CT to obtain shift vectors for an optimal surface match. These shift vectors were subtracted from the vectors obtained by CBCT correction to assess the theoretical setup error that would have occurred if the patients had been positioned using solely the Catalyst (TM) system. The mean theoretical set up-error and its standard deviation were calculated for all measured fractions and the results were compared to patient positioning based on skin marks only. Results: Integration of the surface scan into the clinical workflow did not result in a significant time delay. Regarding the entire group, the mean setup error by using skin marks only was 0.0 +/- 2.1 mm in lateral, -0.4 +/- 2. 4 mm in longitudinal, and 1.1 +/- 2.6 mm vertical direction. The mean theoretical setup error that would have occurred using solely the Catalyst (TM) was -0.1 +/- 2.1 mm laterally, -1.8 +/- 5.4 mm longitudinally, and 1.4 +/- 3.2 mm vertically. No significant difference was found in any direction. For thoracic targets the mean setup error based on the Catalyst (TM) was 0.6 +/- 2.6 mm laterally, -5.0 +/- 7.9 mm longitudinally, and 0.5 +/- 3.2 mm vertically. For abdominal targets, the mean setup error was 0.3 +/- 2.2 mm laterally, 2.6 +/- 1.8 mm longitudinally, and 2.1 +/- 5.5 mm vertically. For pelvic targets, the setup error was -0.9 +/- 1.5 mm laterally, -1.7 +/- 2.8 mm longitudinally, and 1.6 +/- 2.2 mm vertically. A significant difference between Catalyst (TM) and skin mark based positioning was only observed in longitudinal direction of pelvic targets. Conclusion: Optical surface scanning using Catalyst (TM) seems potentially useful for daily positioning at least to complement usual imaging modalities in most patients with acceptable accuracy, although a significant improvement compared to skin mark based positioning could not be derived from the evaluated data. However, this effect seemed to be rather caused by the unexpected high accuracy of skin mark based positioning than by inaccuracy using the Catalyst (TM). Further on, surface registration in longitudinal axis seemed less reliable especially in pelvic localization. Therefore further prospective evaluation based on strictly predefined protocols is needed to determine the optimal scanning approaches and parameters

Feasibility of CycleGAN enhanced low dose CBCT imaging for prostate radiotherapy dose calculation

Daily cone beam computed tomography (CBCT) imaging during the course of fractionated radiotherapy treatment can enable online adaptive radiotherapy but also expose patients to a non-negligible amount of radiation dose. This work investigates the feasibility of low dose CBCT imaging capable of enabling accurate prostate radiotherapy dose calculation with only 25% projections by overcoming under-sampling artifacts and correcting CT numbers by employing cycle-consistent generative adversarial networks (cycleGAN). Uncorrected CBCTs of 41 prostate cancer patients, acquired with ∼350 projections (CBCTorg), were retrospectively under-sampled to 25% dose images (CBCTLD) with only ∼90 projections and reconstructed using Feldkamp–Davis–Kress. We adapted a cycleGAN including shape loss to translate CBCTLD into planning CT (pCT) equivalent images (CBCTLD_GAN). An alternative cycleGAN with a generator residual connection was implemented to improve anatomical fidelity (CBCTLD_ResGAN). Unpaired 4-fold cross-validation (33 patients) was performed to allow using the median of 4 models as output. Deformable image registration was used to generate virtual CTs (vCT) for Hounsfield units (HU) accuracy evaluation on 8 additional test patients. Volumetric modulated arc therapy plans were optimized on vCT, and recalculated on CBCTLD_GAN and CBCTLD_ResGAN to determine dose calculation accuracy. CBCTLD_GAN, CBCTLD_ResGAN and CBCTorg were registered to pCT and residual shifts were analyzed. Bladder and rectum were manually contoured on CBCTLD_GAN, CBCTLD_ResGAN and CBCTorg and compared in terms of Dice similarity coefficient (DSC), average and 95th percentile Hausdorff distance (HDavg, HD95). The mean absolute error decreased from 126 HU for CBCTLD to 55 HU for CBCTLD_GAN and 44 HU for CBCTLD_ResGAN. For PTV, the median differences of D98%, D50% and D2% comparing both CBCTLD_GAN to vCT were 0.3%, 0.3%, 0.3%, and comparing CBCTLD_ResGAN to vCT were 0.4%, 0.3% and 0.4%. Dose accuracy was high with both 2% dose difference pass rates of 99% (10% dose threshold). Compared to the CBCTorg-to-pCT registration, the majority of mean absolute differences of rigid transformation parameters were less than 0.20 mm/0.20°. For bladder and rectum, the DSC were 0.88 and 0.77 for CBCTLD_GAN and 0.92 and 0.87 for CBCTLD_ResGAN compared to CBCTorg, and HDavg were 1.34 mm and 1.93 mm for CBCTLD_GAN, and 0.90 mm and 1.05 mm for CBCTLD_ResGAN. The computational time was ∼2 s per patient. This study investigated the feasibility of adapting two cycleGAN models to simultaneously remove under-sampling artifacts and correct image intensities of 25% dose CBCT images. High accuracy on dose calculation, HU and patient alignment were achieved. CBCTLD_ResGAN achieved better anatomical fidelity

Effectiveness and tolerability of radiotherapy for patients with indolent non-Hodgkin's lymphoma: a monocenter analysis

To analyze the effectiveness and toxicities of radiotherapy in indolent non-Hodgkin's lymphoma (iNHL) patients treated in our institution. Patients with iNHL treated with radiotherapy between 1999 and 2016 were included. The primary endpoint was progression-free survival (PFS). Secondary endpoints were local control (LC), overall survival (OS) and toxicities. PFS, LC, and OS were analyzed using Kaplan-Meier method. Log-rank test was used to investigate the differences between subgroups. Cox proportional hazard model was used for univariate continuous analysis. Seventy-five patients were identified in our institutional database between 1999 and 2016. Fifty-eight (77.3%) had stage I after Ann-Arbor and 17 patients (22.7%) had stage II. The median follow-up was 87~months (95% CI 72-102~months). Median single dose per fraction was 2.0~Gy (range 1.5-2~Gy) and median total dose was 30.6~Gy (range 16-45~Gy). Radiotherapy was performed in 2D (n = 10; 13.3%), 3D (n = 63; 84.0%) and VMAT (n = 2; 2.7%) techniques, respectively. The median PFS was 14.0~years (95% CI 8.3-19.7~years). The estimated PFS after 5 and 10~years were 73.0% and 65.5% in Kaplan-Meier analysis, respectively. The 5- and 10-year LC were 94.9% and 92.3%, respectively. The 5- and 10-year OS were 88.6% and 73.9%. In univariate analyses of PFS, younger patients (≤ 60~years old) had significantly superior PFS to those older than 60~years old (5-year PFS 81.9% vs. 65.1%, p = 0.021). Dose escalation > 36.0~Gy had no prognostic influence in term of PFS (p = 0.425). Extranodal involvement, stage and histology had no prognostic impact on PFS. Depending on the site of lymphomas, the most common acute side effects were: dermatitis CTCAE° I-II (8.0%), xerostomia CTC° I (8.0%), cataract CTC° I (12.0%) and dry eyes CTC° I-II (14.6%). No adverse event CTC° III was reported. Most acute side effects recovered at 3 to 6~months after radiotherapy except for CTC° I cataract and xerostomia. Local Radiotherapy was highly effective for treatment of early stage iNHL with no serious side effects in our cohort. The most acute CTCAE° I-II side effects recovered 3 to 6~months later. Technique advances seem to have further improved effectiveness and tolerability of radiotherapy.Trial registration: Local ethics committee of Ludwig-Maximilian-University (LMU) Munich approved this retrospective analysis on the May 7th, 2019 (Nr. 19-137)