20 research outputs found

    Non-financial motivation practices: Megafon and Nestle

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    The article examines factors which influence the effectiveness of employee motivation, as well as presents the main aspects that need to be taken into account to develop the optimal system of financial and non-financial motivation of employees in international companies. At the same time, a comparative analysis of existing employee motivation practices is provided, using the example of two giant companies: Megafon and Nestle

    Comparative Analysis of University Internationalisation Considering Changes in World Leaders

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    Qualified personnel plays an important role in the competition between countries for economic leadership that enables the transition to a multipolar world. In this context, the higher education sphere is changing; universities worldwide are increasingly striving to attract the best students to their country. The study aims to identify factors causing changes in the position of universities in world regions and develop recommendations for Russian universities to strengthen their positions in the global education market. The methodology relies on the concept of different historical cycles leading to changes in world leaders. The article offers a contemporary interpretation of higher education internationalisation as a multidimensional process instead of fragmentation. The first section explores the issue of changing the world leader; the second identifies transformations in higher education internationalisation in key world regions; the third assesses university internationalisation as a basis for new rankings and self-assessment. A hypothesis about the correlation between the trend of changing global leaders and the place of national universities in international rankings is confirmed. To assess the trend dynamics, the article proposes authors’ multidimensional indices of higher education and university internationalisation for world countries. It is revealed that China, aspiring to be a world leader, has expanded its share in the education market and increased import volumes by more than 1.5 times, sending its students to high-ranking universities, while the USA has weakened its position. Russian universities occupy middle positions in rankings despite the growth of the country’s share in the global education market. Recommendations offered to Russian universities and the option of their self-assessment can be used by strategic development professionals.ΠŸΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ Π² основС формирования Π½ΠΎΠ²ΠΎΠΉ Π°Ρ€Ρ…ΠΈΡ‚Π΅ΠΊΡ‚ΡƒΡ€Ρ‹ многополярного ΠΌΠΈΡ€Π° Π»Π΅ΠΆΠΈΡ‚ конкурСнтная Π±ΠΎΡ€ΡŒΠ±Π° стран Π·Π° экономичСскоС лидСрство, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡ΠΈΠ²Π°ΡŽΡ‚ высококвалифицированныС ΠΊΠ°Π΄Ρ€Ρ‹, сфСра Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования трансформируСтся ΠΏΠΎΠ΄ влияниСм этого Ρ‚Ρ€Π΅Π½Π΄Π°. УсиливаСтся мСТдународная конкурСнция унивСрситСтов Π·Π° ΠΏΡ€ΠΈΠ²Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π² свою страну Π»ΡƒΡ‡ΡˆΠΈΡ… студСнтов. ЦСль ΡΡ‚Π°Ρ‚ΡŒΠΈ: Π²Ρ‹ΡΠ²ΠΈΡ‚ΡŒ Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹, Π²Π΅Π΄ΡƒΡ‰ΠΈΠ΅ ΠΊ измСнСнию ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ унивСрситСтов Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² ΠΌΠΈΡ€Π° Π² условиях смСны глобального ΠΌΠΈΡ€ΠΎΠ²ΠΎΠ³ΠΎ Π»ΠΈΠ΄Π΅Ρ€Π°, Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚Π°Ρ‚ΡŒ Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΈ для российских Π²ΡƒΠ·ΠΎΠ² ΠΏΠΎ ΡƒΠΊΡ€Π΅ΠΏΠ»Π΅Π½ΠΈΡŽ ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ Π½Π° ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ Ρ€Ρ‹Π½ΠΊΠ΅. ΠžΡΠ½ΠΎΠ²Ρƒ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ составили концСпция историчСских Ρ†ΠΈΠΊΠ»ΠΎΠ² Ρ€Π°Π·Π½ΠΎΠΉ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ, Π²Π΅Π΄ΡƒΡ‰ΠΈΡ… ΠΊ смСнС Π³Π»ΠΎΠ±Π°Π»ΡŒΠ½Ρ‹Ρ… Π»ΠΈΠ΄Π΅Ρ€ΠΎΠ², соврСмСнная Ρ‚Ρ€Π°ΠΊΡ‚ΠΎΠ²ΠΊΠ° ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования ΠΊΠ°ΠΊ Π²ΡΠ΅ΠΎΠ±ΡŠΠ΅ΠΌΠ»ΡŽΡ‰Π΅Π³ΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π½ΠΎΠ³ΠΎ процСсса, Π²Π·Π°ΠΌΠ΅Π½ Ρ€Π°Π½Π΅Π΅ Π΄ΠΎΠΌΠΈΠ½ΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΉ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Π°Ρ†ΠΈΠΈ. ΠŸΠ΅Ρ€Π²Ρ‹ΠΉ Π±Π»ΠΎΠΊ исслСдуСт ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡƒ смСны ΠΌΠΈΡ€ΠΎΠ²ΠΎΠ³ΠΎ Π»ΠΈΠ΄Π΅Ρ€Π°, Π²ΠΎ Π²Ρ‚ΠΎΡ€ΠΎΠΌ Π²Ρ‹ΡΠ²Π»ΡΡŽΡ‚ΡΡ измСнСния Π² сфСрС ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования Π² ΠΊΠ»ΡŽΡ‡Π΅Π²Ρ‹Ρ… Ρ€Π΅Π³ΠΈΠΎΠ½Π°Ρ… ΠΌΠΈΡ€Π°, Π² Ρ‚Ρ€Π΅Ρ‚ΡŒΠ΅ΠΌ ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΠΎΡ†Π΅Π½ΠΊΠ° ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ унивСрситСтов Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² ΠΌΠΈΡ€Π° ΠΊΠ°ΠΊ Π±Π°Π·Ρ‹ Π½ΠΎΠ²ΠΎΠ³ΠΎ Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³Π° ΠΈ самооцСнки Π²ΡƒΠ·ΠΎΠ². ΠŸΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π° Π³ΠΈΠΏΠΎΡ‚Π΅Π·Π° ΠΎ совпадСнии ΠΎΠ±Ρ‰Π΅ΠΌΠΈΡ€ΠΎΠ²ΠΎΠ³ΠΎ Ρ‚Ρ€Π΅Π½Π΄Π° смСны глобального Π»ΠΈΠ΄Π΅Ρ€Π° ΠΈ мСста Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… унивСрситСтов Π² ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³Π°Ρ…. Для ΠΎΡ†Π΅Π½ΠΊΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Ρ‚Ρ€Π΅Π½Π΄Π° ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ авторский ΠΌΠ½ΠΎΠ³ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π½Ρ‹ΠΉ индСкс ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования страны ΠΈ унивСрситСтов. ВыявлСно, Ρ‡Ρ‚ΠΎ ΠšΠΈΡ‚Π°ΠΉ, ΠΏΡ€Π΅Ρ‚Π΅Π½Π΄ΡƒΡŽΡ‰ΠΈΠΉ Π½Π° Ρ€ΠΎΠ»ΡŒ глобального Π»ΠΈΠ΄Π΅Ρ€Π°, ΡƒΠ²Π΅Ρ‡ΠΈΠ» долю Π½Π° ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ Ρ€Ρ‹Π½ΠΊΠ΅ ΠΈ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ Π² 1,5 Ρ€Π°Π·Π° нарастил ΠΎΠ±ΡŠΠ΅ΠΌΡ‹ ΠΈΠΌΠΏΠΎΡ€Ρ‚Π°, Ρ‚. Π΅. Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΠ΅ своих студСнтов Π² Π»ΡƒΡ‡ΡˆΠΈΠ΅ Π²ΡƒΠ·Ρ‹ ΠΌΠΈΡ€Π° с высоким Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³ΠΎΠΌ, Π° БША ослабили свои ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΈ. РоссийскиС унивСрситСты Π·Π°Π½ΠΈΠΌΠ°ΡŽΡ‚ срСдниС мСста Π² Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³Π°Ρ…, нСсмотря Π½Π° рост Π΄ΠΎΠ»ΠΈ страны Π½Π° ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ Ρ€Ρ‹Π½ΠΊΠ΅. ΠŸΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Ρ‹Π΅ для российских унивСрситСтов Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΈ ΠΈ Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ провСдСния ΠΈΠΌΠΈ самооцСнки, Π±ΡƒΠ΄ΡƒΡ‚ ΠΏΠΎΠ»Π΅Π·Π½Ρ‹ спСциалистам ΠΏΠΎ стратСгичСскому Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΡŽ

    ΠžΡ‚ Β«ΠΊΠ°Π½Π΄ΠΈΠ΄Π°Ρ‚ΠΎΠ²Β» ΠΊ «гроссмСйстСрам»: стратСгии ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ унивСрситСтов

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    Received October 11, 2021; accepted December 08, 2021.Π”Π°Ρ‚Π° поступлСния 11 октября 2021 Π³.; Π΄Π°Ρ‚Π° принятия ΠΊ ΠΏΠ΅Ρ‡Π°Ρ‚ΠΈ 8 дСкабря 2021 Π³.Relevance. Higher education is one of the main areas for the development of national and world economy. To remain competitive on the national and international markets of higher education, universities need to invest considerable financial, human and other resources into internationalization. There is, however, no β€˜onesizefits-all’ solution and universities may choose from an array of strategies to become more visible on the international arena and to move up the global rankings. Research objective. The purpose of this article is to clarify the concept of internationalization in the field of higher education, to identify the key factors that influence universities’ success in internationalization and to explore the strategies and activities used by universities from different countries to internationalize. Materials and Methods. Methodologically, this study relies on the methods of directed content analysis, cluster analysis with SPSS statistics, case studies and interviews. The sample included 32 universities from Western Europe, China and Japan, Russia and the USA – participants of international programs of competitiveness enhancement. Results. 7 key factors that determine the success of a university’s internationalization efforts were identified, the most important of which are financial resources and international interaction. The study also proposes a methodology based on calculation of the internationalization index, which can be applied to determine this or that university’s type and choose the optimal activities to enhance its internationalization. Conclusions. Relocation of the university to a type (cluster) of a higher level through the implementation of the proposed activities can be considered as a modern way of their internationalization.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ. Π’Ρ‹ΡΡˆΠ΅Π΅ ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ – ΠΎΠ΄Π½ΠΎ ΠΈΠ· основных Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΠΉ развития Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΈ ΠΌΠΈΡ€ΠΎΠ²ΠΎΠΉ экономики. Π§Ρ‚ΠΎΠ±Ρ‹ ΠΎΡΡ‚Π°Π²Π°Ρ‚ΡŒΡΡ конкурСнтоспособными Π½Π° Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΌ ΠΈ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΌ Ρ€Ρ‹Π½ΠΊΠ°Ρ… Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования, унивСрситСтам Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎ ΠΈΠ½Π²Π΅ΡΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ финансовыС, чСловСчСскиС ΠΈ Π΄Ρ€ΡƒΠ³ΠΈΠ΅ рСсурсы Π² ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΡŽ. Однако ΡƒΠ½ΠΈΠ²Π΅Ρ€ΡΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ€Π΅ΡˆΠ΅Π½ΠΈΡ Π½Π΅ сущСствуСт, ΠΈ унивСрситСты ΠΌΠΎΠ³ΡƒΡ‚ Π²Ρ‹Π±ΠΈΡ€Π°Ρ‚ΡŒ ΠΈΠ· мноТСства стратСгий, Ρ‡Ρ‚ΠΎΠ±Ρ‹ ΡΡ‚Π°Ρ‚ΡŒ Π±ΠΎΠ»Π΅Π΅ Π·Π°ΠΌΠ΅Ρ‚Π½Ρ‹ΠΌΠΈ Π½Π° ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ Π°Ρ€Π΅Π½Π΅ ΠΈ ΠΏΠΎΠ΄Π½ΡΡ‚ΡŒΡΡ Π² Π³Π»ΠΎΠ±Π°Π»ΡŒΠ½Ρ‹Ρ… Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³Π°Ρ…. ЦСль ΡΡ‚Π°Ρ‚ΡŒΠΈ – ΠΏΡ€ΠΎΡΡΠ½ΠΈΡ‚ΡŒ ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ†ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Π² сфСрС Π²Ρ‹ΡΡˆΠ΅Π³ΠΎ образования, Π²Ρ‹ΡΠ²ΠΈΡ‚ΡŒ ΠΊΠ»ΡŽΡ‡Π΅Π²Ρ‹Π΅ Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹, Π²Π»ΠΈΡΡŽΡ‰ΠΈΠ΅ Π½Π° успСх унивСрситСтов Π² ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΈΠ·ΡƒΡ‡ΠΈΡ‚ΡŒ стратСгии ΠΈ дСйствия, ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅ΠΌΡ‹Π΅ унивСрситСтами ΠΈΠ· Ρ€Π°Π·Π½Ρ‹Ρ… стран для ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ. Π”Π°Π½Π½Ρ‹Π΅ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΠΈ Π΄Π°Π½Π½ΠΎΠ΅ исслСдованиС опираСтся Π½Π° ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ½Ρ‚Π΅Π½Ρ‚-Π°Π½Π°Π»ΠΈΠ·Π°, кластСрный Π°Π½Π°Π»ΠΈΠ· Π² SPSS, тСматичСскиС исслСдования ΠΈ ΠΈΠ½Ρ‚Π΅Ρ€Π²ΡŒΡŽ. Π’ Π²Ρ‹Π±ΠΎΡ€ΠΊΡƒ вошли 32 унивСрситСта ΠΈΠ· Π—Π°ΠΏΠ°Π΄Π½ΠΎΠΉ Π•Π²Ρ€ΠΎΠΏΡ‹, ΠšΠΈΡ‚Π°Ρ ΠΈ Π―ΠΏΠΎΠ½ΠΈΠΈ, России ΠΈ БША – участников ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡ конкурСнтоспособности. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π‘Ρ‹Π»ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ 7 ΠΊΠ»ΡŽΡ‡Π΅Π²Ρ‹Ρ… Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ², ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΡŽΡ‰ΠΈΡ… успСх усилий унивСрситСта ΠΏΠΎ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π°ΠΆΠ½Ρ‹ΠΌΠΈ ΠΈΠ· ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… ΡΠ²Π»ΡΡŽΡ‚ΡΡ финансовыС рСсурсы ΠΈ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠ΅ взаимодСйствиС. Π’ исслСдовании Ρ‚Π°ΠΊΠΆΠ΅ прСдлагаСтся мСтодология, основанная Π½Π° расчСтС индСкса ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ, с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΉ ΠΌΠΎΠΆΠ½ΠΎ ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΡ‚ΡŒ Ρ‚ΠΈΠΏ Ρ‚ΠΎΠ³ΠΎ ΠΈΠ»ΠΈ ΠΈΠ½ΠΎΠ³ΠΎ унивСрситСта ΠΈ Π²Ρ‹Π±Ρ€Π°Ρ‚ΡŒ ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ направлСния Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ для усилСния Π΅Π³ΠΎ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ΠŸΠ΅Ρ€Π΅ΠΌΠ΅Ρ‰Π΅Π½ΠΈΠ΅ унивСрситСта Π² Ρ‚ΠΈΠΏ (кластСр) Π±ΠΎΠ»Π΅Π΅ высокого уровня Π·Π° счСт Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Ρ‹Ρ… мСроприятий ΠΌΠΎΠΆΠ½ΠΎ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°Ρ‚ΡŒ ΠΊΠ°ΠΊ соврСмСнный способ ΠΈΡ… ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ

    An evaluation of lymphedema using optical coherence tomography: A rat limb model approach

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    Lymphedema is a pathology caused by poor lymphatic flow which may lead to complete disability. Currently, precise, non-invasive techniques for quantifying lymphedema are lacking. In this paper, the results of an in vivo assessment of lymphedema via a developed small-animal model using the hindlimbs of rats and an optical coherence tomography (OCT) technique are presented. This model of lymphedema was based on a surgical lymph node resection and subsequent two-step X-ray exposure. The development of lymphedema was verified via the histological examination of tissue biopsies. The properties of the lymphedematous skin were analyzed in vivo and compared with healthy skin via OCT. The main differences observed were (1) a thickening of the stratum corneum layer, (2) a thinning of the viable epidermis layer, and (3) higher signal attenuation in the dermis layer of the lymphedematous skin. Based on the distribution of the OCT signal’s intensity in the skin, a machine learning algorithm was developed which allowed for a classification of normal and lymphedematous tissue sites with an accuracy of 90%. The obtained results pave the way for in vivo control over the development of lymphedema

    Synergism of antitumor action of dioxadet and cisplatin in model of ascitic ovarian tumor

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    Comparative antitumor activity of cytostatics dioxadet, cisplatin and their combination was studied in model of ascitic ovarian tumor in 38 female Wistar rats. Ascitic ovarian tumor was transplanted intraperitoneally at amount of 5 Γ— 106 tumor cells per rat. Dioxadet andcisplatin were administered intraperitoneally at their single maximal tolerable doses 48 hours after the tumor transplantation: 1,5 and 4,0 mg/ kg b.w., respectively. Drug combination of dioxadet and cisplatin administered by the same way but at one half of maximal tolerable doses. Antitumor effects of the drugs were estimated by increasing life span of the animals. In control group without treatment the average life span was 16 Β± 6,3 days. Dioxadet and cisplatin showed comparable antitumor activity increasing the average life span by 63,1 % and 48,1 %, correspondingly. Drugs combination showed synergistic effect increasing average life span by 107,5 % (p<0,05). Moreover, combinationof dioxadet and cisplatin are characterized by less toxicity compared with cisplatin applied in maximal tolerable dose
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