Obliterative Endoaneurysmorrhaphy with Stent Graft Preservation for Treatment of Type II Progressive Endoleak

Objective/BackgroundPersistent type II endoleak (EL II) with sac enlargement after endovascular repair of abdominal aortic aneurysm requires treatment to prevent rupture. Embolization is not always effective. Conversion to open repair with stent graft (SG) explantation is a high risk option. The aim of this study was to evaluate the feasibility and immediate results of an alternative technique combining obliterative endoaneurysmorrhaphy (OEA) with SG preservation.MethodsThe open surgical technique combined sacotomy, ligation of all patent back-bleeding vessels and SG preservation. The aneurysmal shell was tightly closed over the SG to protect it from the intestines. An intra-aortic occlusion balloon was used when clamping was required.ResultsTwelve patients were treated with the OEA technique at Amiens University Hospital. All 12 procedures were successful. Four patients had previously undergone unsuccessful transarterial or translumbar embolization. Aortic clamping was performed in four cases. No SG migration or graft dislocation was observed. Follow up computed tomography scan at a median of 12 months showed shrinkage of the aneurysm sac with stable diameters and no recurrence of EL II in all cases.ConclusionThe OEA technique is an alternative option for the treatment of progressive EL II, which can be particularly useful after failure of embolization

Pressure and temperature interactions on aerobic metabolism of migrating European silver eel.

International audienceDuring their migration for reproduction, European eels have to cope with many environmental factors changes. The main changes concern hydrostatic pressure and temperature that are important environmental and physiological factors when considering life in the deep sea. We focus on the consequences of pressure (from 0.1 to 12.1MPa by 1MPa steps) and temperature (9, 15, 22 degrees C) shifts on the oxygen consumption (MO(2)) at the whole animal level. Because of their morphological differences, we are also interested in males and females to evaluate the best conditions for migration. Firstly, whatever temperature, males present higher aerobic capacities than females at atmospheric pressure. Secondly, an increase in temperature increases the pressure effects in males (synergy) but decreases them in females (opposite effects). We raise the hypothesis that two different migration strategies could be used in the water column in order to reach the breeding area: males could tend to privilege pressure and cold waters (deep water) and females, on the other hand, could opt for warmer temperature surface waters

High hydrostatic pressure improves the swimming efficiency of European migrating silver eel.

International audienceTo reproduce, European eels must undergo a long migration without feeding. During this migration they have to cope with many environmental factor changes, one of them being hydrostatic pressure. We focus on the effects of hydrostatic pressure on swimming energetics: does the pressure exposure modify swimming efficiency? By using a specially designed Blazka type swimming tunnel able to work under pressure, we have measured oxygen consumption of migrating male silver eels at different swimming speeds (from 0.2 to 1.0 BL/s) first at atmospheric pressure then at 101 ATA hydrostatic pressure. The results show that pressure increases the energetic swimming efficiency by decreasing oxygen consumption for a given swimming speed. Such a pressure effect could represent a remarkable adaptation enabling eels to spare their energy stores and swim for a long time

Segmentation d'images couleur : Application a la quantification de l'immunomarquage

L'analyse de marqueurs immunohistochimiques sur des coupes histologiques est d'un grand intérêt en pathologie tumorale pour le diagnostic, l'évaluation du pronostic et la thérapeutique. Leur quantification pose cependant un problème en raison de la complexité des images liée à la structure du tissu et à la qualité de la coloration. Les facteurs majeurs qui limitent actuellement l'automatisation complète de la mesure sont la segmentation des noyaux sur les images difficiles et la détection des zones marquées par analyse couleur. Le but de ce travail consiste à proposer une stratégie générale permettant la quantification automatisée du rapport d'immunomarquage nucléaire. Un exemple d'application sur des images couleur de cancers du sein est présenté