Muhandislik grafikasi va chizma geometriya fanidan talabalar mustaqil ishini tashkil qilish texnologiyasi

Mazkur maqolada zamonaviy ta’lim jarayonida chizma geometriya va muhandislik grafikasi fanidan talabalar mustaqil ishini tashkil qilish hamda grafik masalalar yechish savodxonligini oshirish bo’yicha metodik tavsiyalar yoritilgan

Risk assessment of Petrov's glacial lake Outburst floods (Kyrgyzstan)

[EN] This thesis shows an Environmental Risk Analysis far systematic and comprehensive study of the status of Petrov's glacial lake also it's possible assessment of the hazard it pose and of the vulnerability of downstream people and property[ES] Esta tesis muestra un Análisis de Riesgos Ambientales para el estudio sistemático y exhaustivo de la situación del lago glacial de Petrov también es posible la evaluación de la amenaza que plantean y de la vulnerabilidad de las personas y de los bienes intermedios.Bekturov, A. (2014). Risk assessment of Petrov's glacial lake Outburst floods (Kyrgyzstan). http://hdl.handle.net/10251/47161Archivo delegad

Zamonaviy o’lchovlar tushunchasi va metrologiyaning o’rni

Maqolada zamonaviy o’lchash asboblarining qo’llanish sohalari, ularning afzalliklar va qiyosiy ko’rsatkichlari to’g’risidagi ma’lumotlar keltirilgan. Shuningdek, hozirgi paytda uch o’lchovli o’lchov vositalarining qo’llanilishi bilan bog’liq bo’lgan savollar yechimi hal qilinganligiga oid bo’lgan ma’lumotlar o’rganilgan

Happy 70th birthday, Professor Sarkyt E. Kudaibergenov

Article featuring research career and main achievements of Prof Sarkyt E. Kudaibergenov to celebrate his 70th Anniversar

Questions of admixture crossing in semi-fine-wool sheep breeding in Kyrgyzstan

The paper deals with the use of admixture crossing in semi-fine-wool sheep breeding in Kyrgyzstan and its results. The purpose of the research was to develop and scientifically substantiate the methods of using the North Caucasian meat and wool breed during admixture crossing for further improvement of the Tian Shan sheep breed. Generally accepted zootechnical methods were used (the classical scheme of introductory crossing), wool qualities were determined on the OFDA device – 2000. The half-blooded (1/2SKTSH) and quarter-blooded (1/4SKTSH) North Caucasian Tian Shan young animals have better wool qualities without reducing the live weight of the crossbreeds. At the same time, the crossbreeds obtained from the back crossing with wool of 58-56 quality in the specific weight of the herd reached 85.5%, and with the most desirable degree of fineness of 56 quality – 63.3%. According to wool density (M+), the proportion of mixed bred young ewes reached 33.3%, which was 25.2% more than that of half-bloods. It was revealed that the inheritance of wool density trait as a result of crossing these breeds had a positive effect on wool productivity. The crossbred wool cut from them had the best marketable appearance. All this makes it possible to switch to the breeding of quarter-blooded North Caucasian Tian Shan animals “in itself” in the future

A genogeographic study of the Kyrgyz mountain merino via microsatellite markers

The aim was to ascertain the genetic and geographical structure of the Kyrgyz mountain merino (KMM). We analyzed DNA samples of 109 Kyrgyz mountain merino specimens, bred in three state breeding factories (STB), including“Orgochor” in the Issykul Province,“Katta-Taldyk” in the Osh Province and STb named after Luschikhin in the Talas Province. We identified 126 alleles in 12 microsatellite markers (McM042, INRA006, McM527, ETH152, CSRD247, OarFCB20, INRA172, INRA063, MAF065, MAF214, INRA005, INRA023). There were 6 to 16 alleles in each locus (mean 10.500 ± 0.957 alleles per locus). We identified 67 rare alleles (prevalence less than 5.0 %), which made up 53.2 % of all alleles found. The greatest number of rare alleles was found in STR-markers of CSRD247, INRA023, INRA005, INRA006, MAF214 and OarFCB20. For each group, there were individual differences in the distribution of allele frequencies across all the STR loci studied. The most significant of them were as follows: with regard to the McM042 locus, allele 87 was major in the TALAS and OSH groups (35.6 and 45.7 %, respectively), whereas allele 95 was major in the ISSYK-KUL group (36.2 %); allele 154 was major in all groups with regard to the INRA172 locus, but it was 1.25 times less prevalent in the ISSYK-KUL and 1.66 times less prevalent in the OSH groups compared to TALAS (55.2 and 41.4 %, respectively), whereas alleles 156 and 158 were found only in the ISSYK-KUL group. Considering the ETH152 locus, 186 allele prevalence in the TALAS group was 51.1 %, but allele 190 was also markedly prevalent in the ISSYK-KUL and OSH groups, 34.5 and 34.3 %, respectively. The genetic division of the studied groups of KMM (with K from 3 to 10) was homogeneous – the contribution of each subcluster was equivalent. The AMOVA analysis revealed that the groups are located equidistantly. To conclude, the genetic diversity of the Kyrgyz mountain merino in three state breeding factories of the Kyrgyz Republic was high and comparable with each other

PEGylated systems in pharmaceutics

This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of various biological barriers and adhesion to mucosal tissues (mucoadhesion), are considered