3,566 research outputs found
Spectacular Role of Electron Correlation in the Hyperfine Interactions in States in Alkaline Earth Ions
The low-lying n(=3,4,5)d states alkaline earth ions are of vital
importance in a number of different physical applications. The hyperfine
structure constants of these states are characterized by unusually strong
electron correlation effects. Relativistic coupled-cluster theory has been
employed to carry out {\it ab initio} calculations of these constants. The role
of the all order core-polarization effects was found to be decisive in
obtaining good agreement of the results of our calculations with accurate
measurements. The present work is an apt demonstration of the power of the
coupled-cluster method to cope with strongly interacting configurations.Comment: Submitted to Physical Review Letters, 3 figures and 5 table
The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation
<p>Abstract</p> <p>Background</p> <p>The majority of our bones develop through the process of endochondral ossification that involves chondrocyte proliferation and hypertrophic differentiation in the cartilage growth plate. A large number of growth factors and hormones have been implicated in the regulation of growth plate biology, however, less is known about the intracellular signaling pathways involved. PI3K/Akt has been identified as a major regulator of cellular proliferation, differentiation and death in multiple cell types.</p> <p>Results and Discussion</p> <p>Employing an organ culture system of embryonic mouse tibiae and LY294002, a pharmacological inhibitor of PI3K, we show that inhibition of the pathway results in significant growth reduction, demonstrating that PI3K is required for normal endochondral bone growth <it>in vitro</it>. PI3K inhibition reduces the length of the proliferating and particularly of the hypertrophic zone. Studies with organ cultures and primary chondrocytes in micromass culture show delayed hypertrophic differentiation of chondrocytes and increased apoptosis in the presence of LY294002. Surprisingly, PI3K inhibition had no strong effect on IGF1-induced bone growth, but partially blocked the anabolic effects of C-type natriuretic peptide.</p> <p>Conclusion</p> <p>Our data demonstrate an essential role of PI3K signaling in chondrocyte differentiation and as a consequence of this, in the endochondral bone growth process.</p
Recoil correction to the bound-electron g factor in H-like atoms to all orders in
The nuclear recoil correction to the bound-electron g factor in H-like atoms
is calculated to first order in and to all orders in . The
calculation is performed in the range Z=1-100. A large contribution of terms of
order and higher is found. Even for hydrogen, the higher-order
correction exceeds the term, while for uranium it is above the
leading correction.Comment: 6 pages, 3 tables, 1 figur
Complete two-loop correction to the bound-electron g factor
Within a systematic approach based on the dimensionally regularized
nonrelativistic quantum electrodynamics, we derive the complete result for the
two-loop correction to order for the factor
of an electron bound in an state of a hydrogenlike ion. The results
obtained significantly improve the accuracy of the theoretical predictions for
the hydrogenlike carbon and oxygen ions and influence the value of the electron
mass inferred from factor measurements.Comment: 11 pages, 1 figur
Toward high-precision values of the self energy of non-S states in hydrogen and hydrogen-like ions
The method and status of a study to provide numerical, high-precision values
of the self-energy level shift in hydrogen and hydrogen-like ions is described.
Graphs of the self energy in hydrogen-like ions with nuclear charge number
between 20 and 110 are given for a large number of states. The self-energy is
the largest contribution of Quantum Electrodynamics (QED) to the energy levels
of these atomic systems. These results greatly expand the number of levels for
which the self energy is known with a controlled and high precision.
Applications include the adjustment of the Rydberg constant and atomic
calculations that take into account QED effects.Comment: Minor changes since previous versio
A new and automated risk prediction of coronary artery disease using clinical endpoints and medical imaging-derived patient-specific insights: protocol for the retrospective GeoCAD cohort study
INTRODUCTION: Coronary artery disease (CAD) is the leading cause of death worldwide. More than a quarter of cardiovascular events are unexplained by current absolute cardiovascular disease risk calculators, and individuals without clinical risk factors have been shown to have worse outcomes. The 'anatomy of risk' hypothesis recognises that adverse anatomical features of coronary arteries enhance atherogenic haemodynamics, which in turn mediate the localisation and progression of plaques. We propose a new risk prediction method predicated on CT coronary angiography (CTCA) data and state-of-the-art machine learning methods based on a better understanding of anatomical risk for CAD. This may open new pathways in the early implementation of personalised preventive therapies in susceptible individuals as a potential key in addressing the growing burden of CAD. METHODS AND ANALYSIS: GeoCAD is a retrospective cohort study in 1000 adult patients who have undergone CTCA for investigation of suspected CAD. It is a proof-of-concept study to test the hypothesis that advanced image-derived patient-specific data can accurately predict long-term cardiovascular events. The objectives are to (1) profile CTCA images with respect to variations in anatomical shape and associated haemodynamic risk expressing, at least in part, an individual's CAD risk, (2) develop a machine-learning algorithm for the rapid assessment of anatomical risk directly from unprocessed CTCA images and (3) to build a novel CAD risk model combining traditional risk factors with these novel anatomical biomarkers to provide a higher accuracy CAD risk prediction tool. ETHICS AND DISSEMINATION: The study protocol has been approved by the St Vincent's Hospital Human Research Ethics Committee, Sydney-2020/ETH02127 and the NSW Population and Health Service Research Ethics Committee-2021/ETH00990. The project outcomes will be published in peer-reviewed and biomedical journals, scientific conferences and as a higher degree research thesis
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