Erste Ergebnisse zur Nutzung eines web-basierten Tests auf Rehabilitationsbedarf bei Versicherten der Deutschen Rentenversicherung

OBJECTIVES: To investigate simultaneous dual-isotope SPECT/CT with two differently radioisotope-labelled albumin-microsphere fractions for treatment planning of hepatic radioembolisation. METHODS: In addition to (99m)Technetium-labelled albumin microspheres (commercially available), we performed labelling with (111)Indium. Binding stability of (111)Indium-labelled microspheres was tested in vitro and in vivo in mice. Simultaneous dual-isotope SPECT/CT imaging was validated in an anthropomorphic torso phantom; subsequently, dual-isotope SPECT/CT was performed under in-vivo conditions in pigs (n = 3) that underwent transarterial injection of (99m)Technetium- and (111)Indium-labelled microspheres in the liver (right and left hepatic artery, respectively), in both kidneys and in the gluteal musculature. In total, n = 18 transarterial injections were performed. RESULTS: In-vitro testing and in-vivo studies in mice documented high binding stability for both (99m)Technetium-labelled and (111)Indium-labelled microsphere fractions. In phantom studies, simultaneous dual-isotope SPECT/CT enabled reliable separation of both isotopes. In pigs, the identified deposition of both isotopes could be accurately matched with intended injection targets (100 %, 18/18 intended injection sites). Furthermore, an incidental deposition of (99m)Technetium-labelled microspheres in the stomach could be correlated to the test injection into a right hepatic artery. CONCLUSION: Simultaneous dual-isotope SPECT/CT after transarterial injection with (99m)Technetium- and (111)Indium-labelled microspheres is feasible. Thus, it may offer additional, valuable information compared to single (99m)Technetium-labelled albumin examinations. KEY POINTS: * Simultaneous dual-isotope SPECT/CT with (111) In- and (99m) Tc-labelled albumin microspheres is feasible. * Differentiation of two microsphere fractions after transarterial injection is possible. * The origin of an extra-hepatic microsphere deposition can be correlated to the corresponding artery. * This technique could reduce the setup time for selective internal radiation treatment

Putative association of a TLR9 promoter polymorphism with atopic eczema.

Toll-like receptors (TLR) play a pivotal role in the induction of first-line defense mechanisms of the innate immune system and trigger adaptive immune responses to microbial pathogens. Genetic variations in innate immunity genes have been reported to be associated with a range of inflammatory disorders. Deficiencies on the level of immunity receptors such as pathogen-recognition receptors are suspected to affect the maturation of our immune system and to avail thereby the high prevalence of atopic diseases and susceptibility of atopic patients to microbial infections. AIMS OF THE STUDY: We evaluated TLR9 as susceptibility gene for atopic eczema (AE). METHODS: Analyses of four tag single-nucleotide polymorphisms in two panels of families containing a total of 483 parent-affected offspring trios as well as a cohort of 274 unrelated adult AE cases and 252 hypernormal population-based controls have been performed. RESULTS: In both family cohorts, polymorphism C-1237T, which is located within the promoter region of the TLR9 gene, was significantly associated with AE, in particular the intrinsic subtype of AE. No associations were seen in the case-control cohort. Luciferase reporter gene assays revealed significantly higher promoter activity of the TT allelic variant at this single nucleotide polymorphism site. CONCLUSION: These observations suggest that the TLR9 promoter polymorphism C-1237T might affect AE susceptibility in particular in patients with the intrinsic variant of AE

Untersuchungen zu Stoffeintraegen in Oberflaechengewaesser sowie zu Stoffumsetzungsprozessen in Fliessgewaessern im Einzugsgebiet der Unteren Spree als Grundlage fuer Sanierungskonzepte Abschlussbericht

SIGLEAvailable from TIB Hannover: F96B1215+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

A STUDY OF PHOTON PRODUCTION IN HADRONIC e+ e- ANNIHILATION

The production of photons ine + e −→γ+hadrons is investigated at three centre of mass energies around 14, 22 and 34 GeV. On average, photons carry 25% of the total available energy, with a multiplicity similar to the charged multiplicity. The inclusive photon spectra are found to scale with the centre of mass energy as a function of the Feynman variablex. π0 and η mesons are reconstructed from their decay photons. The slopes of the spectra are similar to that for charged pions and approximate scaling is observed for π0 production. The mean π0 and η multiplicities are given. The observed photon yield can be fully accounted for by hadron decays and initial state radiation. However, up to one extra photon per event from other sources cannot be excluded